Proceedings - Manfred Donike Workshops

Manfred Donike Workshop - Proceedings of the 39th Cologne Workshop on Dope Analysis 2021
In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021   

TABLE OF CONTENTS

LECTURES

Hullstein I, Yu Q, Dehnes Y:
Carbon isotope ratio determination of seized nandrolone preparations in comparison to results from analyses of 19-norandrosterone in urine samples
13-18 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Thieme D:
'Operation Bloodletting' - practical insights from a major doping trial?
19-23 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Mazzoni I, Ventura R, Daley-Yates P, Collomp K, Saugy M, Buttgereit F, Rabin O, Stuart M:
Defining permitted and prohibited use of glucocorticoids in the anti-doping context Part I. Glucocorticoids: new approach and new regulations
24-29 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Daley-Yates P, Ventura R, Mazzoni I, Collomp K, Saugy M, Buttgereit F, Rabin O, Stuart M: Defining permitted and prohibited use of glucocorticoids in the anti-doping context
Part II. Approach for defining acceptable and unacceptable use of glucocorticoids in sport
30-33 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

POSTER PRESENTATIONS

Haenelt N, Lourens L, Fußhöller G, Geyer H, Goldmann L, Schult C, Schwenke A, Hülsemann F, Gougoulidis V, Blatt C, Thevis M:
Follow-up investigations of atypical passport findings for the ratio 5a-Androstane-3a,17b-diol/5b-Androstane-3a,17b-diol
34-37 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Fußhöller G, Geyer H, Haenelt N, Hülsemann F, Gougoulidis V, Blatt C, Thevis M:
Additional investigations in connection with atypical findings for 19-norandrosterone - a case study
38-40 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Mareck U, Geyer H, Fußhöller G, Haenelt N, Thevis M:
Results of confirmation procedures in the scope of the steroidal athlete biological passport in the Cologne laboratory from 2017 2019
41-44 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Piper T, Geyer H, Toboc A, Ahrens B, Pohanka A, Thevis M:
Recent findings on 7-oxo-DHEA and its improved detection based on reference population-derived thresholds for 7?-OH-DHEA and 5aandrostane-3a,7a-diol-17-one
45-49 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Piper T, Panto S, Thevis M:
Highly sensitive low resolution GCxGC-TOF as a complement in doping control analysis of anabolic androgenic steroids
50-54 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Krug O, Thomas A, Thevis M:
Identification and characterization of urinary isopropylnorsynephrine metabolites
55-59 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Geisendorfer T, Athanasiadou I, Tsivou M, Gmeiner G:
Long-term urinary excretion profile after a single oral administration of acetazolamide
60-63 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Fernández-Alvarez M, Serrano E, Muñoz G:
Specific urinary metabolites of non-prohibited mebeverine: LC-MS/MS monitoring of MAC and DMAC on reporting of p-hydroxyamphetamine
64-68 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Albertsdóttir AD, van Gansbeke W, van Eenoo P, Polet M:
Intact phase II AAS metabolites on GC-M
69-72 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

ubio A, Geyer H, Costa Padilha M, Pereira H, Cameron L, Thevis M:
Higenamine quantification and investigation into structural characteristics of its metabolites in urine samples
73-77 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Martinez Brito D, Leogrande P, de La Torre X, Botrè F:
Analysis of 7-oxo-DHEA metabolites by liquid chromatography mass spectrometry
78-82 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Camuto C, Guglielmelli A, De-Giorgio F, de La Torre X, Mazzarino M, Marti M, Botrè F:
An insight into the metabolism of New Psychoactive Substances: targeted and untargeted metabolic profile of a new mephedrone analogue
83-87 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Camuto C, De-Giorgio F, Fiacco I, Marti M, Mazzarino M, Botrè F:
In vivo metabolism of JWH-175: blood and urine detection of JWH-018 in mice
88-91 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Pühringer M, Gmeiner G:
Detection of S-23 metabolites in urine after a single oral administration using liquid chromatography high resolution mass spectrometry
92-95 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Thomas A, Fox J, Slade S, Kislyuk S, Gastall H, Thevis M:
Preliminary data for ion mobility separation of recombinant and synthetic insulin variants on a cyclic IMS mass spectrometer
96-100 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Stacchini C, Botrè F, de la Torre X, Mazzarino M:
The individual longitudinal profile of IGF-1 in capillary blood: a new ABP parameter?
101-106 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Martín-Navas P, Saavedra MJ, Cortés N, McPherson Medina A, Polo M, Fiallo Fernández T, Rodríguez G, Muñoz G, Montes de Oca Porto R:
A Fit-for-Purpose approach with the Cuban monoclonal antibody CBSSEPO for the ERAs analysis in urine samples
107-111 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Biasini GM, de La Torre X, Botrè F, Donati F:
Detection of hum an Peroxiredoxin-2 in stored erythrocytes: potential biomarker of Autologous Blood Transfusions in doping control
112-116 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Akiyama K, Kageyama S, Okano M:
DNA analysis of dried blood spots and urine for doping control purposes
117-121 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Krug O, Geyer H, Thomas A, Walpurgis K, Piper T, Thevis M: 
Black market products suspected to contain doping relevant ingredients - report for 2019 2020
122-127 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Mareck U, Fußhöller G, Haenelt N, Thevis M:
Risk of unintentional antidoping rule violations by consumption of hemp products
128-132 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Cantón MI, Garcia PP, Serrano E, Muñoz G:
Comparison of the separation of 2-fluoroamphetamine, 3-fluoroamphetamine and 4fluoroamphetamine by gas chromatography-mass spectrometry using different columns and derivatization agents
133-138 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Berghes B, Radu M, Cristea CD, Toboc A, Stan C:
Optimization of a cocaine and benzoylecgonine identification method using the linear ion trap
139-143 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Moleme BJ, Grobbelaar E, Du Preez H:
The influence of gas filter saturation on the chromatographic sensitivity of GC-MS/MS analysis
144-147 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Inthong T, Nimsoongnern S, Wilairat P, Kongpatanakul S:
Workflow Management and Sample Tracking for Doping Analysis
148-151 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Leogrande P, Jardines Garcia D, Domenici E, de La Torre X, Parr MK, Botrè F:
Low-energy electron ionization for steroidomics analysis using highresolution mass spectrometry
152-156 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Wicka M, Grucza K, Stanczyk D, Drapala A, Kowalczyk K, Konarski P, Burstein K, Kwiatkowska D:
Development and validation of a method for the detection of benzodiazepines, barbiturates, imidazopyridine and derivates of cyclopyrrolone in blood by means of LC-MS/MS
157-162 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Mareck U, Fußhöller G, Geyer H, Thevis M:
Simplified confirmation analysis for Carboxy-THC
163-166 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Rubio A, Sigmund G, Piper T, Geyer H, Thevis M:
Evaluation of doping control samples to determine the prevalence of nicotine use by German elite athletes
167-170 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Montes de Oca Porto R, Martinez Brito D, Correa Vidal T, Fiallo Fernández T, Hernández Domínguez D:
hGH levels and gender, sport, and endogenous corticosteroids in a Cuban population. Preliminary results
171-176 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

Wicka M, Kaliszewski P, Grucza K, Stanczyk D, Drapala A, Konarski P, Kowalczyk K, Kwiatkowska D:
Determination method of 27 prohibited glucocorticosteroids in human urine
177-181 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (29). Sport und Buch Strauß - Köln 2021

PRESENTATIONS ABSTRACTS - LECTURES

Salamin O, Nicoli R, Langer T, Schweizer Grundisch C, Boccard J, Rudaz S, Xu C, Pitteloud N, Saugy M, Kuuranne T:
Longitudinal evaluation of multiple biomarkers for the detection of testosterone gel administration in women with normal menstrual cycle
182-183

de Wilde L, van Renterghem P, van Eenoo P:
Long-term stability study and evaluation of intact steroid conjugate ratios after the administration of endogenous steroids
184

Piper T, Geyer H, Nieschlag E, Thevis M:
Carbon isotope ratios of endogenous steroids found in human serum – method development, validation, and reference population-derived thresholds
185-186

Piper T, Haenelt N, Fusshöller G, Geyer H, Thevis M:
Sensitive detection of testosterone and testosterone prohormone administrations based on urinary concentrations and carbon isotope ratios of androsterone and etiocholanolone
187-188

Matos R, Anselmo C, Lopez N, Magalhães A, Sardela V, Pereira H:
Zebrafish water tank (ZWT) model as a tool for metabolic studies. New results for anabolic agents
189

Göschl L:
Detection of phase-II glucuronides of exogenous anabolic androgenic steroids exemplified by stanozolol
190

Görgens C, Ramme A, Guddat S, Schrader Y, Winter A, Dehne E, Horland R, Thevis M:
Organ-on-a-chip: Determine feasibility of a liver microphysiological model to assess long-term steroid metabolites in sports drug testing
191

Wagener F, Möller T, Guddat S, Görgens C, Angelis YS, Petrou M, Lagojda A, Kühne D, Thevis M:
Elimination profiles of microdosed SARM LGD-4033 mimicking contaminated product ingestion
192

Krombholz S, Thomas A, Piper T, Thevis M:
Elimination profile of orally administered phenylethylamine
193

Albertsdóttir AD, van Gansbeke W, van Eenoo P, Polet M:
Non-hydrolysed sulfated metabolites in routine doping control screening, enabled by GC-LE-EI-QTOF-MS
194

Lange T, Thomas A, Görgens C, Bidlingmaier M, Schillbach K, Fichant E, Delahaut P, Thevis M:
Comprehensive insights into the formation of metabolites of the ghrelin mimetics capromorelin, macimorelin and tabimorelin as potential markers for doping control purposes
195

Euler L, Gillard N, Delahaut P, Mürdter T, Schwab M, Thomas A, Thevis M:
Are contaminated eggs a potential source of minute amounts of clomiphene in doping control samples?
196

Keiler A, Zschiesche A, Savill R, Chundela Z, Thieme D:
Biosynthesis of long-term metabolites using HepG2 cells    
197

Loria F, Cox H, Voss SC, Rocca A, Miller G, Townsend N, Georgakopoulos C, Eichner D, Kuuranne T, Leuenberger N:
The Use of RNA-Based 5’-Aminolevulinate Synthase 2 Biomarkers in Dried Blood Spots to Detect Recombinant Human Erythropoietin Micro-Doses
198

Martin L, Ericsson M, Marchand A:
Multiplexed detection of Agents Affecting Erythropoiesis (AAEs) and overall strategy for optimized analysis
199-200

Leuenberger N, Rocca A, Martin L, Marchand A, Ericsson M, Kuuranne T
A fast screening method for the detection of CERA in dried blood spots
201

Thomas A, Krombholz S, Wolf C, Thevis M:
Determination of ghrelin and desacylghrelin in plasma and urine by means of LC-MS for doping controls
202

Gavrilovi? I, Memdouh S, Cowan D, Abbate V:
Improving the detection of peptide hormones for anti-doping purposes
203

Voss SC, Yassin M, Grivel J, Al Hmissi S, Allahverdi N, Nashwan A, Merenkov Z, Al Malki A, Raynaud C, Elsaftawy W, Al Kaabi A, Donati F, Botre F, Mohamed Ali V, Georgakopoulos C, Al Maadheed M:
RBC derived extracellular vesicles as markers for autologous blood doping – a clinical trial
204

Goucher E:
Alternative Approaches Towards Sports Anti-Doping – a Focus on Dried Spot Analysis
205

Levernæs M, Broderstad L, Zandy E, Dehnes Y:
Comparison of dried blood spots and urine as sample matrices in doping control
206

Garzinsky AM, Thomas A, Thevis M:
Insights into the pulmonary elimination of beta-blockers, glucocorticoids and stimulants obtained from post-administration exhaled breath samples
207

Marchand A, Roy D, Lewis J, Mcguire R, Ericsson M:
Development of a miniaturized multiplex immunoassay for Growth Hormone (GH) detection
208-209

Mareck U, Fußhöller G, Geyer H, Huestis MA, Scheiff AB, Thevis M:
Preliminary data on the potential for unintentional anti-doping rule violations by permitted CBD use
210

Danaceau J, Gavilovri? I, Christensen P, Wood M:
Analysis of doping agents by UPC -MS/MS
211

Paßreiter A, Thomas A, Grogna N, Delahaut P, Thevis M:
First Steps toward Uncovering Gene Doping with CRISPR/Cas by Identifying SpCas9 in Plasma via HPLC?HRMS/MS
212

Honesova L, Polet M, van Eenoo P:
A uniform sample preparation procedure for gas chromatography combustion isotope ratio mass spectrometry for all human doping control relevant anabolic steroids using online 2/3-dimensional liquid chromatography fraction collection
213-214

Gavrilovic I, Cowan D, Parr M, Botre F, de La Torre X, Wüst B:
SFC-MS – A New Tool for Anti-Doping Analysis
215

Knoop A, Geyer H, Lerch O, Rubio A, Schrader Y, Thevis M:
Detection of anti-SARS-CoV-2 antibodies in dried blood spots in support of the management of the COVID-19 pandemic in the context of sport
216

Cavalcanti G, Carneiro G, Borges R, Padilha M, Pereira H:
Variable Data Independent Acquisition (vDIA) and Feature-Based Molecular Networking Analysis for Untargeted Screening of Synthetic Cannabinoids
217

Deventer K, van Gansbeke W, Hooghe F, Polet M, van Eenoo P:
Investigation of the urinary excretion of prednisolone and metabolites after nasal administration: Relevance to doping control
218

Ventura R, Daley-Yates P, Mazzoni I, Collomp K, Saugy M, Buttgereit F, Rabin O, Stuart M:
Defining permitted and prohibited use of glucocorticoids in the antidoping context Part III. Establishing reporting levels and washout periods for glucocorticoids
219

Buisson C, Robin B, Frelat C, Amiot V, Narduzzi L, Ericsson M, Collomp K:
Study on hydrocortisone misuse: Topical versus oral administration
220-221

PRESENTATIONS ABSTRACTS - POSTERS

Bressan C, Celma A, Alechaga &, Monfort N, Sancho JV, Ventura R:
Collision cross-section measurements for the structural characterization of sulfate and glucuronide metabolites of anabolic steroids
222

Andersson A, Pohanka A:
The shared fate of norethisterone and levonorgestrel
223

Ponzetto F, Nonnato A, Settanni F, Nicoli R, Kuuranne T, Ghigo E, Mengozzi G:
Extended steroid profiling by single-run UHPLC-MS/MS analysis: first insights into conjugated androgens plasma levels
224-225

Jardines Garcia D, Botrè F, de La Torre X:
Coupling longitudinal steroid profile (ABP – steroid module) with isotopic ratio mass spectrometry values. Athletes cases studies
226

Buisson C, Elloumi A, Figadère B, Ericsson M, Beniddir MA:
The sniffing dog/anti-doping dog Molly - A new dimension of doping controls
227-228

Martinez Brito D, Leogrande P, de La Torre X, Colamonici C, Curcio D, Botrè F:
Should Arimistane be considered a direct metabolite of 7-oxo-DHEA?
229

Pfeffer S, Gmeiner G, Gärtner P:
Synthesis, characterization and application of a marker substance for monitoring 
17-keto-modifications in endogenous steroids caused by microbiological activity
230

Kwon OS, Muresan AR, Rahaman KA, Rafique FB, Kim KH, Lee KM, Min H, Kim HJ, Sung C, Lee J, Son J:
Metabolism of bolasterone by LC-MS/MS and GC-MS/MS
231-232

Kwon OS, Rahaman KA, Muresan AR, Rafique FB, Kim KH, Lee KM, Min H, Kim HJ, Sung C, Lee J, Son J:
Discovery of in vitro generated metabolites of Thymosin ?4 by UHPLCQ-Exactive Orbitrap MS
233-234

Dubey S, Sah S, Singh AK, Jamal H, Singh S, Sahu PL:
Investigation of meclofenoxate stability and profiling of its degradation products in urine for human sports doping control purposes
235-236

Mazzarino M, Camuto C, Comunità F, Stacchini C, Botrè F:
Evaluation of the metabolic behaviour of novel bath salt type drugs by data-independent acquisition mass spectrometry: The case of N-ethyl heptedrone
237

Uçaktürk E, Selbes Y, Demirel HA:
Investigation of ibutamoren and its metabolites in urine samples
238

Marchand A, Martin L, Kafi R, Zhou X, Zhang L, Ericsson M:
Detection of rEPO biosimilar Jimaixin after administration in healthy subjects
239

Reihlen P, Blobel M, Weiß P, Wittmann J, Leenders F, Walpurgis K, Thevis M:
Introduction of a PEGylated EPO-conjugate as internal standard for EPO analysis in doping controls
240

Kempkes R, Schoeps S, Reihlen P, Geyer H, Gotzmann A, Thevis M:
The Cologne hematological APMU: A collaboration between the Cologne laboratory and the National Anti Doping Agency Germany
241

Marchand A, Roulland I, Semence F, Ericsson M:
A simple method for EPO transgene detection in whole blood and dried blood spots
242-243

Mareck U, Geyer H, Schertel T, Petring S, Krug O, Thevis M:
Findings of non-declared doping substances in nutritional supplements in follow up investigations of positive doping cases
244

Dobrescu M, Danila G, Stan C, Toboc A:
A gas chromatography – tandem mass spectrometry (GC-MS) method for the identification of 5-methylhexan-2-amine in food supplements
245

Rzeppa S, Große J, Thieme D:
?8-Tetrahydrocannabinol: Emergence of a less common cannabinoid with a challenging detection
246-247

Kwiatkowska D, Grucza K, Kowalczyk K, Konarski P, Drapala A, Chajewska K, Wicka M:
Ecdysterone - excretion study after ingestion of spinach
248-249

Guddat S, Goergens C, Sobolevsky T, Thevis M:
Meldonium residues in milk- a possible scenario for inadvertent doping in sports?
250

Judák P, Coppieters G, Deventer K, van Eenoo P:
Application of online automatic filtration and filter back-flush solid phase extraction in routine doping control analysis
251

González-Rubio S, Ballesteros-Gómez AM, Carreras D, Muñoz G, Rubio S:
A comprehensive study on the performance of different retention mechanisms in sport drug testing by liquid chromatography tandem mass spectrometry
252

e Wilde L, Roels K, Deventer K, van Eenoo P:
Automated identification of cocaine and benzoylecgonine at 1 ng/mL using turbulent flow online SPE LC-MS/MS
253

Khelifi S, Saad K, Vonaparti A, Mahieddine S, Saleh A, Salama S, Al-Mohannadi M, Al-Thaiban H, Lommen A, Horvatovich P, Beotra A, Abushareeda W, Al Maadheed M, Georgakopoulos C:
Ultra-fast retroactive processing by MetAlign of liquid chromatography/high-resolution full-scan Orbitrap mass spectrometry data in WADA Human Urine Sample Monitoring Program
254

Vonaparti A, Salama S, Mahieddine S, Saleh A, Saad K, Al-Thaiban H, Khelifi S, Maryam A, Saghbazarian S, Al Maadheed M, Georgakopoulos C:
Dilute and shoot screening of doping agents by UHPLC/HR-Orbitrap-MS
255

Knoop A, Fusshöller G, Thevis M:
Identification of hydrafinil metabolites in doping controls
256

Sobolevsky T, Ahrens B:
Biotin as a masking agent in chorionic gonadotropin assays utilizing biotinylated antibodies
257

Anselmo C, Matos R, Pereira H, Martucci ME:
Metabolomic retrospective analysis of HRMS data from cathinones metabolism in zebrafish (Danio rerio)
258
 
SCIENTIFIC BOARD
 
 E. Benetka, Seibersdorf (Austria)
 C. Buisson, Paris (France)
 D. Cowan, London (United Kingdom)
 H. Cox, Los Angeles (USA)
 X. de la Torre, Rome (Italy)
 H. Geyer, Cologne (Germany)
 G. Gmeiner, Seibersdorf (Austria)
 U. Mareck, Cologne (Germany)
 M. Mazzarino, Rome (Italy)
 G. Muñoz, Madrid (Spain)
 R. Montes de Oca Porto, Havana (Cuba)
 M. Okano, Tokyo (Japan)
 H. Pereira, Rio de Janeiro (Brazil)
 T. Piper, Cologne (Germany)
 C. Reichel, Seibersdorf (Austria)
 W. Schänzer, Cologne (Germany)
 M. Thevis, Cologne (Germany)
 D. Thieme, Kreischa (Germany)
 P. van Eenoo, Ghent (Belgium)
 R. Ventura, Barcelona (Spain)

RECENT ADVANCES IN DOPING ANALYSIS (29)         ISBN 978 3 86884 047 6    
_____________________________________________________________________________________

Manfred Donike Workshop - Proceedings of the 38th Cologne Workshop on Dope Analysis 2020
In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020   

TABLE OF CONTENTS

LECTURES

Marchand A, Ericsson M, Audran M, Fenaille F, Capdeville P, Martin L:
EPO Biosimilars with unusual profiles: characterization and detection
13-22 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Heiland CE, Masquelier M:
Sepharose gel beads: an effective technique for recombinant erythropoietin immuno-purification from blood
23-27 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

POSTER PRESENTATIONS

Sigmund G, Geyer H, Goergens C, Thevis M:
Prevalence of the imidazole derivatives naphazoline, oxymetazoline and xylometazoline in doping control samples
28-31 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Wicka M, Kaliszewski P, Grucza K, Stanczyk D, Drapala A, Konarski P, Zalewska Z, Siek P, Michalak D, Kwiatkowska D:
Elimination profile of triamcinolone acetonide and its metabolite in human urine after multiple transdermal administrationed stimulants
32-36 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Barbán Duarte L, Martínez Brito D, Correa Vidal T, Montes de Oca Porto R:
Trend analysis and decision making in the Havana Anti-Doping Laboratory
37-40 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Rodriguez Fernandez A, Laffita D, López Castillo D, Terrero O, Montes de Oca R:
Increase in the incidence of THC in urine samples of athletes in 2019
41-45 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Biasini GM, Donati F, Rutigliano L, de La Torre X, Botrè F:
Proteomic analysis of biomarkers of red blood cells storage: towards the development of direct detection of autologous blood transfusion
46-51 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Donati F, Botrè F, de La Torre X, Sian V, Biasini GM, Concetti L, Rutigliano L:
Evaluation of the impact of genetic polymorphisms on basal values of human serum and urinary biomarkers: implications for anti-doping analyses
52-58 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Momobayashi A, Kageyama S, Okano M:
Detection of homologous blood transfused erythrocytes by means of a two color fluorescence flow cytometric analysis
59-62 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Zhou X, He S, Zhang L, Shen L, He C:
Administration Study of rEPOs circulated in China
63-67 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

He S, Zhou X, Zhang L, Shen L, He C:
Troubleshooting for doping analysis of EPO
68-70 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Somay Selbes Y, Onol S, Kacar T, Demirel AH, Aytekin S:
Effects of protease inhibitors on stability of urine hCG and LH in doping analyses
71-73 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Iannone M, Botrè F, de La Torre X:
Direct and indirect detection of pseudo-endogenous steroids in plasma
74-79 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Son J, Park JW, Lee SH:
Multiple Biomarkers of Anabolic Agent Administration in Urine as Candidates for Doping Diagnosis
80-84 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Danila G, Pop A, Toboc A, Stan C:
7-Keto-DHEA – a case study
85-89 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Geyer H, Fusshöller G, Haenelt N, Mareck U, Blatt C, Gougoulidis V, Hülsemann F, Piper T, Thevis
M:
The ratio 5aAdiol/E as indicator for the detection of testosterone doping in athletes with naturally low T/E – a case study
90-93 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Wen C, Liu X, Tianshuo Z, Jingzhu W:
Isolation of boldenone and its metabolite in urine sample and further determination of the C/ C ratios by gas chromatographycombustion-isotope ratio mass spectrometry
94-97 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Mabusa I, Du Preez H, van der Merwe T:
Proposed suppression of phentermine derivatization by concomitant medication: A GC-MS case study and suggested solution
98-102 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Kaewklum M, Kaewklum S, Dithayam S, Wilairat P, Kongpatanakul S:
Separation and identification of regioisomers of fluoroamphetamine and fluoromethamphetamine in doping control by gas chromatography-mass spectrometry
103-107 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Stacchini C, Dima AP, de La Torre X, Mazzarino M, Botrè F:
In vitro studies of the metabolic profile of different classes of SARMs using liquid chromatographic-mass spectrometric techniques
108-112 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Songsaeng R, Saardpun N, Kusamran T, Kongpatanakul S:
Method Development for Identification of Growth Hormone Releasing Peptides (GHRPs) in Doping Control by UFLC/MS-IT-TOF
113-117 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Ahi S, Dubey S, Bhardwaj A, Sahu PL:
Fast and sensitive detection of small peptides in human urine using liquid chromatography tandem mass spectrometry
118-123 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Berghes B, Radu M, Cristea CD, Toboc A, Stan C:
Validation of HIF activating agents confirmation methods
124-128 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Grucza K, Wicka M, Drapala A, Konarski P, Stanczyk D, Michalak D, Kaliszewski P, Kwiatkowska D:
Impact of various purity grades of acetonitrile and different mass spectrometry ionization methods on limits of detection of dopingsubstances by means of the “Dilute-and-Shoot” approach
129-133 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Alechaga E, Terrero A, Monfort N, Ventura R:
UHPLC-HRMS multi-screening method for doping control analyses in urine samples
134-138 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

de la Cal A, Espinosa P, Blázquez I, Fernández B, García L, de Pedraza L, Carreras D, Muñoz G:
Solving problems with HILIC columns: Compounds with difficult chromatographic behavior
139-143 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Fernández-Álvarez M, Cuervo D, Baltazar-Martins JG, Plata MDM, Muñoz-Guerra JA, Lara B, Del Coso J, Muñoz G, Carreras D:
Determination of tramadol and its metabolites in plasma by using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS)
144-148 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

Cuervo D, Fernández-Álvarez M, Baltazar-Martins JG, Plata MDM, Muñoz-Guerra JA, Lara B, Del Coso J, Muñoz G, Carreras D:
Determination of tramadol and its metabolites in urine via accuratemass quadrupole time-of-flight (Q-TOF) LC/MS
149-152 Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (28). Sport und Buch Strauß - Köln 2020

PRESENTATIONS ABSTRACTS - LECTURES

Gotzmann A:
"Operation Aderlass”: Legislation as a cornerstone of anti-doping
153

Rossi F, Saugy M:
Dried Blood Spots: Alternative matrix to deter and detect Tramadol abuse in road cycling competitions
154

Knoop A, Planitz P, Wuest B, Thevis M:
Evaluation of cobalt in doping control samples: Discrimination of different cobalt sources
155

Paßreiter A, Thomas A, Walpurgis K, Thevis M:
First steps towards uncovering gene doping with CRISPR/Cas9
156

Coll S, Monfort N, Alechaga &, Matabosch X, Pérez-Mañà C, Ventura R:
Evaluation of the reporting level to detect betamethasone misuse in sports: additional studies after intranasal and intramuscular administrations
157

Walpurgis K, Rubio A, Wagener F, Krug O, Knoop A, Görgens C, Guddat S, Thevis M:
Elimination profiles of microdosed ostarine mimicking contaminated products ingestion
158-159

Garzinsky A, Thomas A, Krug O, Thevis M:
Exhaled breath in doping controls: characterization of SensAbues® sampling devices using an aerosol test generator
160

Mongongu C, Ericsson M, Madi Moussa E, Audran M, Coudoré F, Marchand A, Buisson C:
Quantitative determination of IGF-I in dried blood using Volumetric Absorptive Micro-sampling and Top-down analysis with LC-HRMS
161-162

Miller G, Madrigal K, Lamm J, Husk J, Eichner D:
Detecting growth hormone abuse in dried capillary blood spots: results from a largescale field trial and a controlled administration study
163

Dib J, Thevis M, Thomas A:
Fully-automated "offline" dried blood spot (DBS) extraction and its implementation into doping control analysis
164

Lange T, Thomas A, Walpurgis K, Thevis M:
Fully automated dried blood spot sample preparation enables the detection of lower molecular mass peptide and non-peptide doping agents by means of LC-HRMS
165

Solheim SA, Stillesby Levernæs MC, Mørkeberg J, Juul A, Upners EN, Nordsborg NB, Dehnes Y:
Dried Blood Spot analysis of testosterone esters is applicable in doping analysis
166

Padilha M, Cavalcanti G, Gomes M, Carneiro G, Oliveira F, Pereira H:
Can Graviola juice result an AAF for higenamine?
167

de Wilde L, Roels K, van Eenoo P, Deventer 
Update on the use of 2D-LC-MS/MS in doping analysis
168

de La Torre X, Colamonici C, Molaioni F, Jardines D, Iannone M, Botrè F:
Intentional or accidental clostebol detection. An Italian Story
169

Görgens C, Walker K, Boeser C, Wijeratne N, Martins C, Guddat S, Thevis M
Paperspray mass spectrometry – A potential novel technique for the detection of polar compounds in sports drug testing? A pilot study
170

Kraiem S, Al-Mahamed H, Al-Menhali A, Al-Thani N, Helaleh M, Samsam W, Al-Jaber MY, Bouabdallah S, Touil S, Georgakopoulos C, Beotra A, Mohamed Ali V, Al Maadheed M:
Analytical strategy for the detection of ecdysterone and its metabolites in vivo in uPA(+/+)-SCID mice with humanised liver, human urine samples and estimation of the prevalence of its use in anti-doping samples
171-172

Salamin O, Nicoli R, Schweizer C, Xu C, Pitteloud N, Saugy M, Kuuranne T:
Longitudinal steroid profiling in healthy women: impact of transdermal testosterone
administration 173

Zanitzer K, Erceg D, Forsdahl G, Gmeiner G:
Comparison of the ratios of sulpho-conjugated and glucuroconjugated phase II metabolites of endogenous steroids in urine samples after administration of testosterone preparations via UHPLCHRMS
174-175

de Wilde L, Roels K, van Renterghem P, van Eenoo P, Deventer K:
Steroid profiling in urine of intact glucuronidated and sulfated steroids using liquid chromatography-mass spectrometry
176

Albertsdóttir AD , van Gansbeke W , Coppieters G , Balgimbekova K , Polet M , van Eenoo P:
Searching for new long term metabolites of metenolone anddrostanolone by gas chromatography-mass spectrometry with a focus on non-hydrolysed sulphates
177

Putz M, Piper T, Thevis M:
Metabolite identification studies of trenbolone
178

Piper T, Heimbach S, Adamczewski M, Thevis M:
Investigations on the potential impact of different doping agents on the steroid profile by means of a steroidogenesis assay
179

Polet M, de Wilde L, van Renterghem P, van Eenoo P:
A fast GC-C-IRMS method for the detection of epiandrosterone sulfate in urine
180

Hülsemann F, Fußhöller G, Lehn C, Thevis M:
Excretion of 19-norandrosterone after consumption of boar meat
181

Piper T, Rubio A, Thevis M:
Investigations on carbon isotope ratios of potential novel long term metabolites of testo-sterone and testosterone prohormone misuse - 5α- and 5β-androstane-3α,17α-diol
182-183

Iannella L, Botrè F, Colamonici C, Curcio D, Ciccarelli C, de La Torre X:
Potential masking effect of different prednisolone based pharmaceutical formulations on IRMS confirmation analysis
184

Piper T, Fußhöller G, Geyer H, Danila M, Toboc A, Thevis M:
Detecting the misuse of 7-oxo-DHEA by means of carbon isotope ratio mass spectrometry in doping control analysis
185

Coppieters G, Judák P, van Haecke N, van Renterghem P, van Eenoo P, Deventer K:
A high-throughput assay for the quantification of intact Insulin-like Growth Factor I in human serum using online SPE-LC-HRMS
186

Renovato-Martins M, Amorim C, Magdalena I, Dudenhoeffer-Carneiro AC, López S, Nunes I, Pizzatti L, Aquino Neto F, Mirotti L, Pereira HM:
Monocytes as sensors of autologous blood transfusion detection
187

Judák P, Coppieters G, Deventer K, Van Eenoo P:
Urinary detection of insulin analogues: Improvements in the Ghent laboratory
188


Dehnes Y, Bogetveit S, Solheim SA, Sletten C, Mørkeberg J, Baastrup Nordsborg N:
Effect of testosterone administration on GH-biomarkers IGF-1 and PIIINP
189

Renovato-Martins M, Dudenhoeffer-Carneiro AC, Du Rocher-Silva B, Soares F, Aquino Neto FR, Hasan M, Rahaman KA, Muresan A, Oh-Seung K, Mirotti L, Pereira HM:
Erythrocyte phenotyping of international athletes by flow cytometry
190

Narduzzi L, Buisson C, Morvan M, Marchand A, Audran M, Le Bouc Y, Ericsson M, Le Bizec B, Dervilly G:
ABP-omics: a combined use of the haematological module and the “steroidomics passport” to track GH users
191-192

Voss SC, Elsaftawy W, Saghbazarian S, Al-Kaabi A, Mohamed Ali V, Georgakopoulos C, Al Maadheed M, Orie N:
Testing the applicability of HRP-conjugated Anti-EPO antibodies for direct rhEPO detection – proof of concept
193

Dehnes Y, Miller G, Naud J, Martin L, Reihlen P, Reichel C:
Inter-laboratory validation of biotinylated clone AE7A5EPO-antibody for EPO detection by single blotting of urine and blood samples
194

Reichel C, Erceg D, Lorenc B, Scheiblhofer V, Farmer L, Zanitzer K, Geisendorfer T, Gmeiner G:
Data from a low-dosed rEPO administration study
195-196

Leuenberger N, Salamin O, Gottardo E, Schobinger C, Reverter-Branchat G, Segura J, Saugy M, Tissot J, Kuuranne T:
Detection of stimulated erythropoiesis using the transcriptomic ALAS2 biomarker in dried blood spot samples
197

Walpurgis K, Weigand T, Knoop A, Thomas A, Reichel C, Dellanna F, Thevis M:
Detection of follistatin-based inhibitors of the TGF-β signaling pathways in serum/plasma by means of LC-HRMS/MS & Western blotting
198

Miller G, Cox H, Manandhar A, Husk J, Eichner D:
Evaluation of CD71, Band3, and serum markers as evidence of recombinant EPO use:
results from a non-drug longitudinal study and a blinded, placebo-controlled administration study
199

PRESENTATIONS ABSTRACTS - POSTERS

Nazir J, Cowan D, Caldwell R, Walker C, Bartlett C, Brailsford A, Wolff K:
A Menu Driven Laboratory Information Management System (DCLIMS) for Anti-Doping Laboratories
200

Son J, Cho Y:
Model System for Brain Doping: Identification of the Correlation between Performance Enhancing and Alterations of Neurochemical Profiling
201

Araujo A, da Costa Nunes IK, Sardela V, Pereira H, Cabral L, Anselmo C:
Application of the Zebrafish Water Tank Model to investigate the budesonide metabolic profile
202

Prado E, Gomes G, Lima de Sá C, Matos R, Sardela V, Anselmo C, Nunes I, Ramalho G, Vanini G, Padilha M, Oliveira MA, Oliveira A, Canuto C, Amaral L, Siqueira D, Aquino Neto FR, Pereira HM:
Study of the metabolism of the cathinones α-PVP, methylone and 4-chloro-dimethylcathinone through the Zebrafish Water Tank Model
203-204

Pettersson-Bohlin K, Sjöö M, Sjöö J:
The sniffing dog/anti-doping dog Molly - A new dimension of doping controls
205

Mazzarino M, Ambrosio G, Grieco A, Parr MK, de La Torre X, Botrè F:
Ecdysterone: A snapshot of use in the athlete’s population
206

Ahi S, Nimker V, Sharma R, Narula B, Sahu PL:
Continuous Quality Improvement in doping control laboratories: Implementation of ISO/IEC 17025:2017 and WADA ISL 2019, Challenges and Future Perspective
207

Vargas García-Tenorio S, Serrano Garde E, Soldevilla Navarro AB, Cortes Carrillo N, Martín Escudero P, Muñoz-Guerra JA, Galindo Canales M, del Prado N, Fuentes Ferrer M, Fernández Pérez C, Brouwer B, Benish P:
Indirect detection of steroids abuse in sports based on androgenic activity measurement by AR Calux bioassay
208-209

Voss SC, Elsaftawy W, Saghbazarian S, Al-Kaabi A, Al-Hamad K, Al Maadheed M, Nofal A, Georgakopoulos C:
IAAF Doha 2019 World Championships – Sysmex XN-1000 Hematology Results
210

Mazzarino M, di Costanzo L, Comunità F, de La Torre X, Botrè F:
Dried blood spot in doping control test: evaluation of different blood collection device
211

Reihlen P, Blobel M, Völker-Schänzer E, Schänzer W, Geyer H, Thevis M:
Case reports of re-analyzed rEPO suspicious doping control urine samples from 2011 2014
212

Ericsson M, Bhuiyan H, Ekström L:
GHRH daily administration can be determined with longitudinally monitoring of IGF-I
213

Alechaga E, Pont L, Terrero A, Monfort N, Ventura R:
Optimization of an immunopurification method for the screening of growth hormone-releasing hormones in urine doping control
214-215

Martin L, Maurice T, Audran M, Ericsson M, Marchand A: AWARD!
Detection of a non-erythropoietic EPO, Neuro-EPO, in blood after intra-nasal administration in rat
216-217

Kaliszewski P, Siek P, Zalewska Z, Michalak D, Grucza K, Wicka M, Kwiatkowska D:
Method development for the detection of carbamylated erythropoietin (CEPO) for doping control purposes
218

Zhou X, He S, Zhang L, Shen L, He C:
Assessment on rat EPO as Internal Standard in Doping ControlSamples for EPO Detection with SAR-PAGE using Biotinylated Primary Antibody
219

Reihlen P, Weiß P, Blobel M, Walpurgis K, Thevis M:
Evaluation of PEGylated EPO-conjugates as internal standards for EPO analysis in doping controls
220

Kiousi P, Fragkaki AG, Lyris E, Petrou M, Georgakopoulos C, Angelis YS:
Novel Long-Term Markers for Methylnortestosterone Misuse in Human Urine
221

Martinez Brito D, Botrè F, de La Torre X:
Mass spectrometric analysis of 7-oxygenated androst-5-ene steroids - an in vitro study
222

Martinez Brito D, Iannone M, Tatangelo M, Molaioni F, Botrè F, de La Torre X:
Old compounds, new alertness: In vitro and in vivo experiments using methyltestosterone
223-224

Deventer K, van Gansbeke W, van Eenoo P:
Alternative approach for the detection of aminoglutethimide
225

Andersson A, Elings Knutsson J, Ekström L, Lindén Hirschberg A:
ABP profile in relation to transdermal testosterone administration in women
226

Suominen T, Ericsson M, Ekström L, Schulze J:
ABP-profile in relation to the menstrual cycle
227

Andersson A, Eklund E, Hirschberg AL, Ekström L:
ABP urinary metabolites and how they correlate to serum hormone levels in female athletes
228

Brailsford A, Wojek N, Chih-Wei C, Walker C, Cowan D, Wolff K:
Determination of anabolic steroids in dried blood using microsampling and gas chromatography-mass spectrometry: application to a testosterone gel administration study
229

Cavalcanti G, Zhu Y, Wijeratne N, Martins C, Padilha M, Pereira H:
Application of VeriSpray ion source Triple Quadrupole Mass Spectrometry for stimulants and narcotics analysis in oral fluid
230

Kowalczyk K, Torres Elguera JC, Konopka A, Jarek A, Stanczyk D, Wicka M, Kwiatkowska D, Bulska E:
In vitro metabolic studies of emerging selective androgen receptor modulators (PF-0620414, TFM-4-AS-1, BMS 564929 and GSK 2881078) and implementation of the results into LC-MS/MS-based dopingcontrol analysis
231-232

Sato M, Kageyama S, Okano M:
Detection of the selective estrogen receptor modulator Bazedoxifene in human urine by LC-MS/MS
233

Dubey S, Sah S, Sahu PL:
Comprehensive screening of doping agents by ‘dilute and shoot’ urine analysis using high resolution/high accuracy mass spectrometry
234

Mongongu C, Marchand A, Buisson C, Coudoré F, Audran M, Ericsson M, Madi Moussa E:
A sensitive detection of synthetic IGF-I analogs using a mass spectrometric immunoassay and nano-ultra-high-performance liquid chromatography coupled to high resolution mass spectrometry
235

Rahaman KA, Muresan AR, Rafique FB, Kim KH, Lee KM, Min H, Kim HJ, Sung C, Son J, Lee J, Kwon OS:
Metabolites of TB-500 peptide in various in-vitro enzyme systems by UHPLC-MS/MS
236

Rafique FB, Muresan AR, Rahaman KA, Kim KH, Lee KM, Min H, Kim HJ, Sung C, Son J, Lee J, Kwon OS:
In vitro phase I metabolism study of the diuretic clopamide by LCMS/MS
237

Pettersson-Bohlin K, Oesterlind L, Börjesson A, Ekström L:
Bis-(4-fluouphenyl)-methylpiperazine detection in urine from female and male Caucasians after oral lomerizine intake
238

__________________________________________________________________

Manfred Donike Workshop - Proceedings of the 37th Cologne Workshop on Dope Analysis 2019
In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019   

TABLE OF CONTENTS

LECTURES

Perspective Article:
Biasini GM, Botrè F, de la Torre X, Donati F:
Electrical brain stimulation: the rise of a new doping method?
11‐16 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

POSTER PRESENTATIONS

Piper T, Thevis M:
Do urinary concentrations of dimethyl sulfoxide and its metabolite dimethyl sulfone indicate topical administrations of doping agents?
17‐20 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Muñoz G , Baltazar‐Martins JG , Plata MDM , Muñoz‐Guerra J , Carreras D , del Coso J:
Prevalence of use of tramadol in conjunction with other non‐ prohibited stimulants
21‐24 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Martin L, Martin J, Hoang O, Collot D, Audran M, Marchand A:
Detection of rEPOs in plasma from ABP blood samples: impact of freeze‐thaw cycleand hemolysis
25‐29 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Romberg S, Kempkes R, Thevis M:
Athlete Biological Passport in Practice: Computer Assisted Evaluation of Sysmex Measurements at the Analysis ,
30‐34 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Fußhöller G, Geyer H, Schänzer W, Thevis M:
Bacterial activities in urine samples: Formation of metandienone and 6β‐hydroxymetandienone from the internal standard methyltestosterone – a case study
35‐38 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Rodriguez Fernandez A, Martinez Brito D, Correa Vidal T, Lopez Castillo D, Montes de Oca Porto R:
Evaluation of the steroid profile in Latin‐American population of male football players,
39‐44 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Iannone M, di Murro V, de la Torre X, Botrè F:
Effects of non‐banned and non‐monitored substances ‐ synthetic isoflavones, resveratrol and polydatin ‐ on the parameters of the urinary steroid profile
45‐49 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Comunità F, Botrè F, Grippo D, Montesi G, de la Torre X, Mazzarino M:
Azole antifungals and their effect on the urinary steroid profile: a dose response relationship study
50‐53  In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Oliveira FA, Oliveira FAG, Labanca BDJ, Padilha MC, Pereira HMG:
Report of four months experiencing the 2018 Technical Document for endogenous anabolic androgenic steroids in LBCD
54‐57 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Masquelier M, Andersson A, Ericsson M:
Confirmation of oxandrolone metabolites or the story of a false ”false positive”
58‐61 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Fußhöller G, Guddat S, Schänzer W, Geyer H, Thevis M:
Testolactone – Derivatisation Artifact due to the Incorporation of an Ethylmercapto Group
62‐65 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Shiomura S, Kageyama S, Okano M:
Urinary steroid profiles and carbon isotope ratios after administration of testosterone gel in Japanese subjects
66‐70 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Jardines D, Curcio D, Colamonici C, Botrè F, de la Torre X:
Inter‐individual behavior of the endogenous reference compounds
71‐74 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Ericsson M, Thörngren J, Hopcraft O:
A new sample preparation procedure for GC‐C‐IRMS analysis using mixed mode SPE and MS/MS detection for HPLC‐fractionation
75‐80 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Ndlovu F , Van der Merwe M , Goebel C , Grainger J:
Development and validation of a method for the detection of small peptides in doping control
81‐86 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Radu M , Berghes B , Toboc A:
Development and validation of a LC‐HRMS method for the detection of small peptides in human urine
87‐90 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Pettersson‐Bohlin K, von Walden J, Ericsson M, Thörngren J:
Confirmation of derivatized methylhexanamine and its isomers using Q‐exactive
91‐93 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Olgaz Bingöl S, Onol S, Aytekin S, Basaran AA:
Differentiation of Modafinil and Dimenhydrinate by UPLC‐ESI‐MS/MS in Doping Analysis
94‐97 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

Krug O , Thomas A , Walpurgis K , Piper T , Geyer H , Thevis M:
Black market products suspected to contain doping relevant ingredients ‐ annual report for 2018
98‐102 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (27). Sport und Buch Strauß - Köln 2019

PRESENTATIONS ABSTRACTS ‐ LECTURES

Garzinsky AM , Walpurgis K , Krug O , Thevis M:
Does saliva contribute to exhaled breath samples collected by means of an electret membrane?  
103

Van Wagoner R, Miller G, Husk J, Bruno B, Eichner D:
Investigating oral fluid and exhaled breath as alternative matrices for anti‐doping testing: a collaborative study with minor league baseball and the partnership for clean competition
104

Pereira HM, Sardela V, Matos R, Prado E, Gomes G, Lima de Sá C, Anselmo C, Nunes I, Ramalho G, Padilha M, Vanini G, Oliveira MA, Oliveira A, Amaral L, Canuto C, Siqueira D, Ambrósio J, de Aquino Neto FR:
Zebrafish water tank model: scale down, study pipeline and reference collections
105

Coll Camenforte S , Matabosch Gerones X , Llorente Onaindia J , Pérez Mañá C , Monfort Mercader N, Monfort Faure J , Ventura Alemany R:
Elimination profile of triamcinolone hexacetonide and its metabolites in human urine and plasma after a single intra‐articular administration
106

Reichel C, Fröschl H, Gmeiner G:
Establishing doping‐related reference distributions for cobalt in human urine
107‐108

Lange T , Walpurgis K , Thomas A , Geyer H , Thevis M:
Development of two complementary LC‐HRMS methods for analyzing Sotatercept in dried blood spots for doping controls
109

Thomas A, Thevis M:
Identification of metabolites of peptide‐derived drugs using skin tissue microsomes and Isotope‐labeled Reporter Ion Detection strategy
110

Piper T, Fusshöller G, Schänzer W, Thevis M:
Investigations into the in vivo metabolism of Methylstenbolone
111‐112

Cavalcanti G, Gujar A, Pereira H, Padilha M:
Advanced Electron Ionization source (AEI source) : Improving the reliability of confirmation methods in sports drug testing
113

Polet M, Van Gansbeke W, Albertsdóttir AD, Coppieters G, Deventer K, Van Eenoo P:
Analysis of non‐hydrolyzed sulfated steroids by gas chromatography mass spectrometry
114

Martinez‐Brito D, de la Torre X, Botrè F:
7‐Keto‐DHEA: metabolite or precursor? Potential pitfalls in interpreting the analytical results and WADA list
115

Mazzarino M, Martellone L, Comunità F, de la Torre X, Botrè F:
Evaluation of the efficacy of the protocols used in the anti‐doping tests to reveal the presence of 5α‐reductase inhibitors
116

Alechaga E, Esquivel A, Monfort N, Ventura R: Potential of endogenous steroid sulfate metabolites as markers of intramuscular administration of testosterone in Caucasian and Asian population
117

Miller G, Bruno B, Eichner D, Thevis M:
Using pigs as an in vivo metabolic model for performance‐enhancing drugs
118

Ponzetto F, Nicoli R, Kuuranne T, Saugy M, Boccard J, Rudaz S:
Identification of novel serum markers for testosterone administration by untargeted steroidomic analysis
119

Nair V, Eichner D:
TDSSA based testing at SMRTL – results and trends
120

Keiler AM, Savill R, Zierau O, Vollmer G, Thieme D: Comparison of steroidogenic metabolism in two in vitro cell culture models
121

Judak P, Van Eenoo P, Deventer K:
DoCoLab’s experience in peptide (MW > 2 KDa) analysis
122

Aguilera R, Al‐Hilal N, Mansuor S, Sliman H, Georgakopoulos C:
The overview results and IRMS data from the 18th Jakarta Palembang Asian and Para‐Asian Games 2018
123

Iannella L, Colamonici C, Curcio D, Botrè F, de la Torre X:
Development and validation of a GC‐C‐IRMS method to confirm the exogenous origin of urinary prednisolone and prednisone
124‐125

Putz M , Piper T , Dubois M , Delahaut P , Thevis M:
Analysis of endogenous steroids in urine by means of isotope ratio mass spectrometry and immunoaffinity purification
126

Piper T , Fußhöller G , Schänzer W , Thevis M:
Investigations on the in vivo metabolism of 5α‐androst‐2‐en‐17‐one
127‐128

Narduzzi L , Dervilly‐Pinel G , Marchand A , Audran M , Le Bizec B , Buisson C:
GH‐Omics: a metabolomics approach to detect growth hormone administration
129‐130

Pizzatti L, Lopez SB, Rayol VA, Pereira HMG:
Digital PCR analysis in Dried Blood spots: Erythropoietin (EPO) Gene Doping detection method updated
131

Heiland C, Masquelier M, Bhuiyan H, Ericsson M: A simple method to immunopurify ESAs from urine, serum or Dried Blood Spot (DBS) tests aiming to optimize EPO screening
132

Walpurgis K , Thevis M , Thomas A:
Detection of the myostatin‐neutralizing antibody Domagrozumab in plasma/serum by means of Western blotting and LC‐HRMS
133

Leuenberger N, Ramirez Cuevaz K, Schobinger C, Barge J, Kuuranne T, Donzé O:
Erythroferrone as sensitive biomarker to detect stimulation of erythropoiesis
134

Voss S, Al Hammad K, Samsam W, Georgakopoulos C, Al Maadheed M, Cherif A, Wilson M, Townsend N, Balanos G, Lucas S:
The effect of a novel Living High Training Low intervention of the ABP and EPO SAR‐PAGE analysis
135

Nunes IK, Amorim C, Dudenhoeffer‐Carneiro AC, Pereira H, Sardela P, Sardela V, Mirotti L, Renovato‐Martins M:
Potential biomarkers for autologous blood transfusion detection
136

Reichel C, Gmeiner G, Thevis M:
Detection of Follistatin 344
137‐138

PRESENTATIONS ABSTRACTS ‐ POSTERS

Lommen A, Nielen MWF, Horvatovich PL, Vonaparti A, Georgakopoulos C, Al‐Muraikhi AE, Al Maadheed M:
New software tool for liquid chromatography retention time modelling and prediction using quantitative structure‐chromatographic retention relationships
139

Dib J, Geyer H, Sigmund G, Bosse C, Glatt A, Geisendorfer T, Tsivou M, Gmeiner G, Thevis M:
Is heptaminol a metabolite of the emerging stimulant octodrine?
140

Miyamoto A, Sato M, Kageyama S, Okano M:
Analysis of tretoquinol (trimetoquinol) and its metabolites in human urine by LC‐MS/MS
141

Yan K, Wang X, Wu Y, Luan Z, Gao X, Wang R:
The risk experiment and evaluation of higenamine positive result possibility after human take lotus plumule capsule
142

Son J, Cho Y, Oh‐Seung K: Profiling analysis of neurotransmitters for brain doping using liquid chromatographytandem mass spectrometry in urine
143

Athanasiadou I , Vonaparti A , Dokoumetzidis A , Saleh A , Miriam M , Al Maadheed M , Valsami G, Georgakopoulos C:
Effect of hyperhydration on pharmacokinetics and detection of orally administered budesonide in doping control analysis
144‐145

Athanasiadou I , Dokoumetzidis A , Voss S , El Saftawy W , Al Maadheed M , Valsami G , Georgakopoulos C:
Hyperhydration effect on pharmacokinetic parameters and detection sensitivity of recombinant human erythropoietin in urine and serum doping control analysis
146‐147

Bressan C, Alechaga E, Cuadras S, Garrostas L, Monfort N, Ventura R, Ayala JF, Santos FJ, Moyano E:
Analysis of hydroxylated phenylalkylamine stimulants in urine by GC‐APPI‐HRMS
148

Jarek A, Urbaniak A, Tarka M, Wojtowicz‐Zawadka M, Pasik M, Stanczyk D, Kwiatkowska D:
Nicotine ingestion among sportsmen in Poland in 2012 – 2018
149

Walpurgis K, Scheiff AB, Welz M, Müller‐Reul J, Görgens C, Guddat S, Fußhöller G, Dib J, Thevis M:
Pilot study on the effects of intravesical oxybutynin hydrochloride instillations on the validity of doping control urine samples
150

Grucza K , Wicka M , Kowalczyk K , Stanczyk D , Kaliszewski P , Michalak D , Szutowski M , Kwiatkowska D:
Identification of glucuronide conjugate of furosemide in routine doping control analysis
151

Jarek A, Urbaniak A, Tarka M, Wojtowicz‐Zawadka M, Chajewska K, Kowalczyk K, Stanczyk D, Kwiatkowska D:
Cannabinoid use among athletes in Poland from 2009 to 2018
152

Andersson A, Ericsson M:
LabWare LIMS for Doping Control Laboratories
153

Mazzarino M, Piantadosi C, Comunità F, de la Torre X, Botrè F:
Urinary excretion profile of prednisone and prednisolone after systemic administration
154

Martinez Brito D, de la Torre X, Botrè F:Metabolism of Arimistane in humans. Identification of urinary metabolites by time‐offlight mass spectrometry
155

Hautbergue T , Soidiki N , Chu‐Van E , Audran M , Fenaille F , Buisson C:
Untargeted metabolomics for evidencing stanozolol misuse
156‐157

Al‐Khelaifi F , Donati F , Botrè F , Al Maadheed M , Georgakopoulos C , El‐Rayess M:
Metabolomics In Anti‐Doping Research
158

Marchand A , Martin J , Collot D , Hoang O , Roulland I , Semence F , Sottas P , Varlet‐Marie E, Audran M:
Combined administration of microdoses of growth hormone and erythropoietin: effects on performance and evaluation of GH detection using anti‐doping methods
159‐160

Marchand A , Rouland I , Semence F , Schröder K , Domergue V , Audran M:
Detection of Hypoxia‐Regulated MicroRNAs in Blood as Potential Biomarkers of HIF Stabilizer Molidustat
161‐162

Knoop A, Thomas A, Thevis M:
Probing for the mitochondrion derived AMPK‐activating peptide MOTS‐c in human blood employing HPLC‐US‐MS/MS
163

Dørum S , Sletten C , Fredriksen PM , Dehnes Y:
The stability of CERA in urine and blood
164

Heiland C, Masquelier M, Bhuiyan H, Ericsson M:
New extraction and analysis techniques of Dried Blood Spot tests for anti‐doping screening of EPO
165

Toboc A, Stan C, Stanescu A, Solomon A:
ESAs Limit of Detection Related to Urine pH
166

Donati F, Marino AM, Biasini GM, de la Torre X, Botrè F:
Detection of circulating hematopoietic stem cells in whole blood in the view of an antidoping context
167

Reihlen P, Blobel M, Thevis M:
Evaluation of Labimage Software – a tool for densitometric EPO analysis
168

Saad K , Vonaparti A , Athanasiadou I , Saleh A , Abushareeda W , Alwahaibi A , Khan BFA , Aguilera R , Kraiem S , Horvatovich PL , Al‐Muraikhi AE , Al Maadheed M , Georgakopoulos C:
Population Reference Ranges of Urinary Endogenous Sulfate Steroids Concentrations and Ratios as Complement to the Steroid Profile of the Athlete Biological Passport in Sports Antidoping
169

Kiousi P, Fragkaki AG, Kioukia‐Fougia N, Angelis YS:
Derivatization of phase II metabolites of AAS for confirmation methods. A case study for mesterolone
170

Martinez Brito D, Notarianni ML, Iannone M, Botrè F, de la Torre X:
Validation of sulphates deconjugation for metabolic studies
171

Emery C, Schweizer Grundisch C, Kuuranne T, Baume N:
Management of the APMU steroidal process in compliance with WADA regulations
172

Mazzarino M, Senofonte M, de la Torre X, Botrè F:
Immunopurification of proteins by monolithic microcolumns. The case of insulin analogues
173

Ucaktürk E , Basaran AA:
Effect of Mobile Phase Additives on The Sensitivity of Prohibited Peptides by Electrospray Ionization Triple Quadrupole Tandem Mass Spectrometry
174

Mazzarino M , Wuest B , de la Torre X , Botrè F:
Comprehensive liquid chromatography triple quadrupole mass spectrometry method for the detection of low molecular weight doping agents .
175

Wojtowicz‐Zawadka M, Szczepanska Z, Jarek A, Pasik M, Stanczyk D, Kwiatkowska D:
Importance of internal standards in GC‐MS/MS quantitative methods in view of doping control ‐ theoretical and experimental investigation'  176

Velasco B , López A , Rodriguez ME , Mendoza N , Rodríguez L , Mercado K:
Simultaneous determination of clenbuterol and ambroxol in human urine using liquid chromatography‐tandem mass spectrometry
177

Min H , Seo J , Lee JH , Kim M , Jeong H , Sung C:
Single‐Step Quantification of human Growth Hormone Biomarker using Quenchbodies
178

Wojtowicz‐Zawadka M , Kwiatkowska D , Jarek A , Chajewska K , Szczepanska Z , Assemat G , Gilard V , Malet‐Martino M:
Presence of anabolic androgenic steroids and stimulants in supplements bought on websites from Poland and France in 2016
179

______________________________________________________________

Manfred Donike Workshop - Proceedings of the 36th Cologne Workshop on Dope Analysis 2018
In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018   

TABLE OF CONTENTS

LECTURES

Kwon OS, Son J, Kim HJ, Kim KH, Lee K, Min H, Sung C, Jeon M, Xu YL, Lee J:
Anti‐Doping Reports in Pyeongchang Olympic and Paralympic Winter Games 2018
11‐20 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Krug O, Thomas A, Geyer H, Thevis M:
Testing doping agents from exhaled breath – Pilot study data
21‐28 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Lalonde K, Couture M, Charlebois A, Ayotte C:
Linearity, stability and quantitation issues relating to the Agilent 7010 axial sources
29‐35 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Flenker U, Riemann P, Hülsemann F, Gougoulidis V, Thevis M, Schänzer W:
Intracrine androgen metabolism. Fundamentals and a new approach to make use of 13C/12C signals of endogenous Steroids
36‐42 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Barber A, Lalonde K, Ayotte C:
Summary of results from 5 years of IRMS testing
43‐48 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Naud J, Desharnais P, Ayotte C:
Development of a capillary‐electrophoresis method for the detection of recombinant erythropoietins
49‐57 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Masquelier M, Heiland C, Bhuiyan H, Erlandsson G, Molin A, Magnus E:
Optimization of ESAs detection in urine and blood: comparison of different immunopurification techniques
58‐65 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

POSTER PRESENTATIONS

Martin‐Navas P, de la Fuente C, Carreras D:
Macro ABP tool: Data exportation from Sysmex XT2000i (Roche) to LIMS/ADAMS
66‐70 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Bican GM, Colev JC, Berghes B, Macovei R, Ionică M:
Cobalt Detection by Graphite Furnace Atomic Absorption Spectrometry in Urine Samples
71‐75 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Krug O, Thomas A, Walpurgis K, Piper T, Laußmann T, Röder R, Thevis M:
Black market products suspected to contain doping relevant ingredients ‐ annual report for 2017
 76‐81 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Grucza K, Kaliszewski P, Kowalczyk K, Pasik M, Stańczyk D, Wicka M, Szutowski M, Kwiatkowska D:
Detection of dorzolamide in athlete urine following ophthalmic application
82‐85 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Pettersson‐Bohlin K, Magnus E, Von Walden J, Thörngren J:
Derivatization allows for detection of Tuaminoheptane confirmation on Q‑exactive
86‐88 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Panan S, Pootrakronchai R, Wiriyakosol N, Kusamran T, Kongpatanakul S:
Method development for specific confirmation of β2‐agonists in doping control
89‐93 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Pootrakronchai R, Panan S, Viriyakhasem N, Ditthayam S, Wilairat P, Kongpatanakul S:
Measurement of enantiomeric composition of clenbuterol in athlete’s urine at NDCC
94‐97 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Bican GM, Colev JC, Berghes B, Dobrescu M, Ionica M:
Cocaine Confirmation in Urine Samples
98‐103 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Wicka M, Stańczyk D, Michalak D, Kaliszewski P, Grucza K, Kowalczyk K, Pawluczyk R, Kwiatkowska D:
Determination of excretion profile of trimetazidine in urine by means of LCMS/MS
104‐108 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Görgens C, Guddat S, Södje D, Geyer H, Thevis M:
Detection of myo‐inositol trispyrophosphate (ITPP) in human urine following an oral administration of ITPP – a pilot study
109‐113 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Kaliszewski P, Kowalczyk K, Grucza K, Roguska K, Zalewska Z, Turek‐Lepa E, Michalak D, Wójcikowska‐Wójcik B, Wicka M, Kwiatkowska D:
Detection of hexarelin and its metabolites in urine after oral ingestion by means of LC/MS/MS
114‐117 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Guddat S, Görgens C, Geyer H, Pfanner T, Thevis M:
Clomiphene ‐ targeting of the unchanged drug results in unusual prolonged detection windows in urine
118‐121 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Salvacion S, Brooker L, Edey C, Mullens B, Kazlauskas R, Goebel C:
Steroid results from an excretion study with an epiandrosterone (3β‐hydroxy5α‐androstan‐17‐one) containing supplement
122‐126 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Mazzarino M, Paolillo I, Comunità F, de la Torre X, Botrè F:
Carbonic anhydrase inhibitors: an evaluation of the excretion profile of dorzolamide after different administration routes and doses
127‐132 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Colev JC, Bican GM, Berghes B, Dobrescu M, Radu M, Smarandache C:
Adrafinil and Modafinil Detection in Urine Samples
133‐138 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Espinosa P, Blázquez I, de la Cal A, Fernández B, García L, de Pedraza L, Muñoz G, Carreras D:
Oxilofrine: Ephedrine minor metabolite
139‐144 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

He C, Wu M, Zhang L, Zhou X:
Circulating microRNA as biomarker of human growth hormone administration to male
145‐148 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Große J, Chundela Z, Lang R:
Screening and Confirmation of Endogenous and Exogenous Anabolic Steroids using the Agilent 7010 GC/MS Triple Quad
149‐152 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Masquelier M, Löfgren H, Dubedout A, Mukai Y, Ericsson M:
Detection of exogenous anabolic androgenic steroids in drugs‐of‐abuse urine samples with UHPLC‐HRMS after enzymatic hydrolysis and direct injection
153‐160 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Iannone M , Matteucci R , Botrè F , de la Torre X:
Development and application of analytical procedures for the analysis of the sulphate metabolites of anabolic androgenic steroids
161‐166 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Mareck U, Fußhöller G, Geyer H, Görgens C, Guddat S, Haenelt N, Romberg S, Schänzer W, Thevis M:
Urinary ethyl glucuronide in doping control samples – evaluation of gender, sport discipline, type of control and concentration
167‐169 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Obaid N, AlYazedi S, Sliman H, Aguilera R, Alsayrafi M, Georgakopoulos C:
AMDIS NIST Algorithm as Purity Measurement of the Chromatographic Peak IRMS
170‐172 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

Romberg S , Sauer M , Klose C , Schänzer W , Thevis M:
Paperless Communication of Sample Collection Documentation
173‐178 In: Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (26). Sport und Buch Strauß - Köln 2018 

PRESENTATIONS ABSTRACTS ‐ LECTURES

Sardela V, Anselmo C, Carvalho A, Oliveira D, de Araújo A, Santos G, Carneiro G, Ribeiro W, de Aquino Neto FR, Padilha M, Gomes M, da Motta M, Nunes I, Labanca B, Pereira HM:
Zebrafish water tank in doping control: model perspectives
179

Goebel C:
Providing analytical services for the testing program of the XXI Commonwealth Games Gold Coast, Australia
180

Van Wagoner R, Nair V, Miller G, Eichner A, Bhasin S, Deuster P, Speiser P, Eichner D:
Specialty Testing at SMRTL— Application of Anti‐Doping Testing Outside of Competitive Athletics
181

Kuuranne T, Baume N:
Responsiveness to anti‐doping organizations and support to result management – expectations, practicalities and restrictions from the laboratory perspective
182

Georgakopoulos C, Elaradi A, Vonaparti A, Abushareeda W, Horvatovich P, Alsayrafi M, Lommen A: Ultra‐fast Reprocessing of HR FS LC/Orbitrap/MS data by MetAlign for Screening in Retroactive Analysis
183‐184

Knoop A, Thomas A, Thevis M:
MOTS‐c: Introducing a mitochondrion derived peptide activating AMPK and its detection in human plasma employing HPLC‐US‐MS/MS
185

Walpurgis K, Thomas A, Lange T, Reichel C, Geyer H, Thevis M:
Combined detection of the ActRII‐Fc fusion proteins Sotatercept (ActRIIA‐Fc) and Luspatercept (modified ActRIIB‐Fc) in serum by means of immunoaffinity purification, tryptic digestion, and LC‐MS/MS
186

Sardela P, Sardela V, Silva A, Pereira H, Aquino Neto FR:
Metabolomic Investigation of Stimulant Abuse in Athletes by Liquid Chromatography High Resolution Mass Spectrometry and Multivariate Statistical Analysis
187

De Wilde L, Roels K, Polet M, Van Eenoo P, Deventer K:
Identification and confirmation of diuretics and masking agents in urine by turbulent flow online SPE LC‐MS/MS for doping control
188

Judák P, Goebel C, Grainger J, Van Eenoo P, Deventer K:
Two years of experience in small peptide analysis using dilute and shoot methodology
189

Thomas A, Thevis M:
Confirmation of prohibited peptides by LC‐MS
190

Polet M, Van Gansbeke W, Van Eenoo P:
GC‐QTOF‐MS: towards a complete and open screening method
191

Miller G, Eichner D, Willick S, Hill B, Nair V, Moore C:
Clomiphene administration to males results in a testosterone increase and is accompanied by a lengthy, isomer‐specific detection window in urine
192

Krumbholz A, Hameder A, Stöver A, Geffert C, Graw M, Thieme D:
The influence of ethanol consumption on the endogenous biosynthesis of the glucocorticosteroids cortisol and cortisone
193‐194

Ventura R, Coll S, Matabosch X, Papakonstantinou K, Pérez‐Mañá C, Mateus JA:
Additional studies on budesonide therapeutic use and misuse in sports
195

Baume N, Ponzetto F, Schweizer Grundisch C, Kuuranne T:
Steroidal APMU of the Lausanne laboratory: past, present and future
196

Esquivel López A , Ventura Alemany R , Monfort Mercader N , Alechaga Silva É:
Evaluation of endogenous steroid sulfates as markers of testosterone oral misuse
197

Aguilera R, Georgakopoulos C, Alsayrafi M, Sliman H, AlYazedi S, Obaid N:
The soft exogenous isotope contribution in low concentration steroids samples from IRMS notifications has been studied
198

de la Torre X , Colamonici C , Curcio D , Botrè F:
Improving detection capacity of GC‐C‐IRMS: Gas chromatography large volume injection
199

Putz M, Piper T, Casilli A, Radler de Aquino Neto F, Pigozzo F, Thevis M:
Development and validation of a multidimensional gas chromatography/combustion/isotope ratio mass spectrometry‐based test method for analyzing urinary steroids in doping controls
200

Buisson C , Audran M , Frelat C , Martinat N , Collomp K:
Metabolic and isotopic signature of DHEA administration in women
201

Hülsemann F, Gougoulidis V, Thevis M:
Potential cause for atypical 19‐norandrosterone IRMS findings
202

Piper T, Putz M, Thevis M:
Carbon isotope ratio analysis of epiandrosterone based on enzymatic solvolysis and multidimensional gas chromatography/combustion/isotope ratio mass spectrometry
203‐204

Moncrieffe D, Cowan DA, Parkin MC:
Peptide selection for the quantification of P‐III‐NP in human serum by mass spectrometry
205‐207 

Ericsson M, Bhuiyan H, Lehtihet M, Ekström L:
Follow up of doping with low doses of recombinant human growth hormone: comparison between longitudinally monitoring of P‐III‐NP, IGF‐1 and GH2000 score and the thresholds of the isoform and the biomarker tests
208

Leuenberger N , Schobinger C , Kuuranne T:
Circular RNA‐based Biomarkers in Dried Blood Spots for the Detection of Stimulated Erythropoiesis
209

Martin L, Audran M, Marchand A:
Development of an Isoelectric focusing method (IEF) for the screening of all rEPOs and ActRIIFc proteins
210

Reichel C, Gmeiner G, Thevis M:
An updated protocol for the detection of Sotatercept and Luspatercept in human serum
211‐212

Pizzatti L, Lopez S, Rayol V, Mury F, Fernandes T, Pereira H, Aquino Neto FR:
Gene Doping analysis: ready or not?
213

PRESENTATIONS ABSTRACTS ‐ POSTERS

Du Preez H , Van Zyl H:
A Risk Management Plan for the South African Doping Control Laboratory
214

Velasco B, Mercado K, Mendoza N, Rodriguez L, Mendez E, Camacho E:
Stability study of urine reference material and results of a proficiency test
215

Son J, Min H, Lee KM Sung C, Jeon M, Kim HJ, Kim KH, Lee J, Kwon O:Development of Doping‐Laboratory Information Management System (d‐LIMS) for Highthroughput Doping Process in Olympics
216

Son J , Park JW:
Effective Identification Tool for Adverse Analytical Findings on Illegal Drug Use in Sports by iD2 : Intelligent Doping Diagnosis
217

Nimker V , Jamal H , Ghosh PC , Jain S , Beotra A:
Effect of varying concentration of phospholipids and cholesterol on masking potential of liposomes on various doping agents
218

Kowalczyk K, Grucza K, Wicka M, Sakowska‐Bak, Roguska K, Pawluczyk R, Tarka M, Turek‐Lepa E, Kwiatkowska D:
Detection of bemitil and its metabolite in urine by means of LC‐MS/MS in view of doping control analysis
219

Velasco B, Martinez A, Perez J, Rodriguez L, Rodriguez ME, Bautista J:
Detection of Clenbuterol in several parts of bovine carcass using HPLC/MS and its enantiomeric distribution
220

Mazzarino M, Rizzato N, Stacchini C, de la Torre X, Botrè F:A further insight on the metabolic profile of SR9009 221

Fragkaki A, Sakellariou P, Kiousi P, Kioukia‐Fougia A, Tsivou M, Petrou M, Angelis I:
Human in vivo metabolism study of LGD‐4033
222‐224

Suominen T, Rautava K, Leinonen A:
Urinary excretion profiles of 19‐norandrosterone after oral administration of lynestreno l andnorethisterone
225

Keiler AM, Zierau O, Wolf S, Diel P, Schänzer W, Vollmer G, Thieme D, Wolber G, Parr MK:
Detection of androgen‐ and estrogen‐receptor mediated activities of 4‐hydroxytestosterone, formestane and their human metabolites in yeast based assays
226

de la Torre X, Martinez Brito D, Colamonici C, Botrè F:
Metabolism of formestane in humans. Identification of urinary biomarkers for antidoping analysis after different administration routes
227

Okano M, Sato M, Kageyama S:
Determination of lomerizine and its metabolites in human urine after oral administration
228

Piper T, Dib J, Fusshöller G, Thevis M:
Studies on the in vivo metabolism of the new SARM YK11: In‐house synthesis of 2 metabolites useful for routine doping control analysis
229

Görgens C, Guddat S, Thomas A, Thevis M:
Recent improvements concerning the screening of peptides (< 2 kDa) in sports drug testing – sample preparation, mass spectrometric detection, and data review
230

Donati F, Botrè F, De la Torre X, Iannella L, Vannelli E:
Analysis of prohibited growth factors in doping control: serum concentration ranges in a reference population of athletes
231

Martin L, Zouhiri N, Audran M, Marchand A:
Validation of a method for a combined detection of activin receptor type IIA‐Fc and IIB‐Fc fusion proteins in human blood
232

Ohta M, Saito M, Sato M, Kageyama S, Okano M:
Evaluation of the effect of Insulin‐like Growth Factor‐I administration on hGH biomarkers assay
233

Toboc A, Danila MG, Pop AM, Bican GM, Radu M, Stanescu AC:
Population – based investigation of relationship between urinary hormonal biomarkers
234

Han B, Song HJ, Kim H, Sung C, Kim KH, Lee KM, Kim HJ, Lee J, Son J, Kwon O, Min H:
Large peptides doping analysis at the PyeongChang Winter Olympic & Paralympic Games 2018: Validation, Implementation and Case report
235

Martinez Brito D, Bueno Fis E, Fiallo Fernandez T, Torres Castellanos M, Correa Vidal MT, Montesde Oca R:Application of the Ultra Micro Analitycal System (SUMA) technology for prescreening purposes to detect hCG in urine 236

Min H, Yu S, Kim H, Lee J, Lee KM, Kim HJ, Kwon O, Sung C:
PNA Intermediated Capture Assay: High‐throughput Analysis of Exogenous DNA for Gene Doping
237

Mäkelä R, Suominen T, Leinonen A, Harju L:
Validation of a microplate enzyme immunoassay for measurement of luteinizing hormone (LH) in urine
238

Lange T, Walpurgis K, Thomas A, Thevis M:
Determination of Sotatercept (ACE‐011) in dried blood spots for doping control analysis by means of LC‐HRMS
239

Nunes I, Amorim C, Renovato M, Dudenhoeffer‐Carneiro AC, Pereira HM, Mirotti L, Sardela V, Sardela P:
Biomarkers analysis from stored red blood cells as a tool for blood transfusion detection
240

Forsdahl G, Kratena N, Geisendorfer T, Pilz SM, Göschl L, Pfeffer S, Weil M, Thevis M, Enev VS, Gärtner P, Gmeiner G:
Synthesis and characterization of a long‐term metabolite of dehydrochloromethyltestosterone
241‐242

Andersson A, Villén T, Ericsson M:
A comparison of Athlete and Drugs of Abuse Steroid findings
243

Brailsford A , Wojek N , Majidin M , Cowan D , Walker C:
Carbon Isotope Measurements of Available Steroid Preparations: Implications for Anti‐Doping
244

Dubey S, Singh SP, Sah S, Jain S:
Identification and separation of nine alkyl amines in urine using dilute and shoot LC‐MS/MS analysis in sports doping control
245

Walpurgis K , Thomas A , Dellanna F , Schänzer W , Thevis M:
Detection of the human anti‐ActRII antibody Bimagrumab in serum by means of affinity purification, tryptic digestion, and LC‐HRMS: Analysis of authentic clinical samples
246

Dib J, Guddat S, Geyer H, Görgens C, Thevis M:
Detection of the Hypoxia‐Inducible Factor (HIF) stabilizer drug candidate BAY 85‐3934 (Molidustat) in routine doping controls
247

Narciso J , B. Silva R , Luz S:
Uncertainty of examination/qualitative analysis results: Identification of doping agents in urine by GC‐MS/MS
248‐249

Juchelka D , Tuthorn M , Piper T , Thevis M:
Undisputable results by coupling of GC‐IRMS with high‐resolution mass spectrometry for final confirmation in sports drug testing
250 

_______________________________________________________________________

Manfred Donike Workshop - Proceedings of the 34th Cologne Workshop on Dope Analysis 2017
In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

TABLE OF CONTENTS

LECTURES

Mazzarino M, Comunità F, de la Torre X, Botrè F:
Effects of antifungals administration on the determination of the parameters of the steroid profile
12‐17 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Zhou X, Zhang L, Shen L, Wang Y, Xu Y, Luan Z, Cheng Y, Yang X:
Follow‐up Investigation of two rhEPO AAF Cases – Comparison of Erythropoietin Electrophoretic Migration Behavior between Urine and Blood
18‐24 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

POSTER PRESENTATIONS

Edey C, Goebel C, Brooker L:
A snapshot of salbutamol findings in samples analysed by the Australian laboratory in 2016
25‐28 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Wang Z, Xiao Y, Xu Y:
Monitor Program of Clenbuterol Contamination in 30 Chinese Volunteers Urine by LC‐MS/MS
29‐32 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Wicka M, Stanczyk D, Michalak D, Kaliszewski P, Zalewska Z, Wójcikowska‐Wójcik B, Szczepanska Z, Kwiatkowska D:
Fentanyl detection in real urine sample
33‐36 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Görgens C, Thevis M, Schänzer W, Geyer H, Guddat S, Bosse C:
Investigation of urinary detection windows after multiple oral dosages of meldonium ‐ a pilot study
37‐40 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Masquelier M, Thörngren JO, Petterson‐Bohlin K, Andersson A, Heiland C, Ericsson M:
A unified robotized sample preparation for chromatographic screening of doping substances
41‐46 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Comunità F, de la Torre X, Mazzarino M, Botrè F:
Higenamine and coclaurine positive doping case associated with herbal massage cream use
47‐50 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Grucza K, Chołbiński P, Wicka M, Kowalczyk K, Pasik M, Stańczyk D, Szutowski M, Kwiatkowska D:
Excretion study of Higenamine following single oral dose of contaminated dietary supplement
51‐55 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Yan K, Chang W, Ma Y, Wang Z, Dong Y, Xu Y:
Detection of higenamine by LC‐MS/MS method, and some relevant study progress
56‐59 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Geyer H, Sigmund G, Krug O, Mareck U, Gougoulidis V, Schänzer W, Thevis M:
Contaminated nutritional supplements as possible source for findings of low concentrations of methylhexaneamine in doping control samples ‐ a case study
60‐62 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Koehler K, Geyer H, Schultze G, Parr MK, Guddat S, Braun H, Mareck U, Thevis M, Schänzer W:
Nutritional Supplements: Still a Risk of Inadvertent Doping? An Extended International Follow‐up
63‐68 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Krug O, Walpurgis K, Thomas A, Piper T, Sigmund G, Schänzer W, Thevis M:
Black market products suspected to contain doping relevant ingredients ‐ annual report for 2016
69‐74 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Iannone M, Cardillo N, Botrè F, de la Torre X:
Effects of the synthetic isoflavones methoxyisoflavone and ipriflavone on the catalytic activity of CYP19
75‐79 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Iannone M, Parenti S, Jardines D, Botrè F, de la Torre X:
Human metabolism of synthetic isoflavones by GC‐q‐TOF
80‐85 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Agon VV, Grainger J, Trout G, Goebel C:
Proof of concept for the detection of clandestine compounds in urine samples using metabolomics
86‐90 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Putz M, Piper T, Schänzer W, Thevis M:
In vitro metabolism studies of SARM YK‐11
91‐94 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Petterson Bohlin K, Ericsson M:
Detection of small peptides in urine using LC‐HRMS
95‐97 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Walpurgis K, Thomas A, Dellanna F, Geyer H, Schänzer W, Thevis M:
Multiplexed detection of ActRII‐Fc fusion proteins in serum by means of Western blotting and LC‐HRMS
98‐101 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Kaliszewski P, Kowalczyk K, Roguska K, Zalewska Z, Grucza K, Michalak D, Wojcikowska‐Wojcik B, Burkhard‐Jagodzinska K, Wicka M, Kwiatkowska D:
Influence of oral administration of hexarelin on concentrations of hGH dependent biomarkers IGF‐I and PIIINP in serum in context of anti‐doping testing
102‐104 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Stinfil JC, Naud JF, Desharnais P, Ayotte C:
Evaluation of the restandardized insulin‐Like growth factor‐I (IGF‐I) assay for the biomarkers test
105‐108 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Desharnais P, Naud JF, Ayotte C:
Single‐blotting for ESA analysis of serum/plasma samples by IEF and SARPAGE after immunomagnetic beads isolation
109‐114 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Stan C, Stanescu A, Toboc A, Pop V:
Modification of serum sample preparation protocol to eliminate the crossreactions and improve the sensitivity of SAR‐PAGE method for ESAs
115‐119 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Asawesna C, Nimsoongnern S, Inthong T, Seetapun S, Kusamran T, Kongpatanakul S:
Urinary luteinizing hormone (LH) levels in male athletes during 3‐years routine doping control analysis at the NDCC Bangkok
120‐123 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Stinfil JC, Chapot R, Desharnais P, Naud J, Ayotte C:
Decreased P‐III‐NP concentration measurement in hemolysed serum samplesand its effect on GH‐Score
124‐127 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Schweizer Grundisch C, Baume N, Kuuranne T:
Steroid profile evaluation following oral testosterone administration coupled to alcohol intake
128‐132 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Donati F, Mascia E, Orlandi S, Stampella A, Pirri D, Iannella L, Botrè F, de la Torre X:
Genotypic variability and doping control: effects of the polymorphism of the family of UGT2B genes on a reference population
133‐135 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Nimsoongnern S, Weewong C, Lohwithee S, Wiriyakosol N, Wilairat P, Kongpatanakul S:
Sample pretreatment for confirmation of 19‐norsteroids by GC‐C‐IRMS in doping control
136‐139 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Wang J, Wen C, Yang W, Liu X:
IRMS Analysis of 11β‐Hydroxyandrosterone after Androstenedione Administration
140‐144 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Suominen T, Kuuranne T, Harju L, Leinonen A:
Screening of doping agents by means of LC‐TOF‐MS part II: dilute‐and‐shoot screening of acidic compounds
145‐147 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

Saardpun N, Asawesna C, Wilairat P, Kusamran T, Kongpatanakul S:
Application of LC/MS‐IT‐TOF for screening of WADA prohibited doping peptides
148‐151 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (25). Sport und Buch Strauß - Köln 2017 

PRESENTATIONS ABSTRACTS ‐ LECTURES

Sardela V, Padilha M, Casilli A, Oliveira F, Levy R, Cavalcanti G, Oliveira F, Pereira H, Mirotti L, Duarte AC, Carneiro AC, Araújo A, Evaristo J, Nogueira F, da Costa G, Pizzatti L, de Aquino Neto F:
Doping control improvements between summer Olympics and the Rio 2016 Olympic and Paralympic Games
152‐153

Mirotti L, de Aquino Neto F, Pereira H, Carneiro M, Amaral A, Dudenhoeffer‐Carneiro AC:
Human Growth Hormone (hGH) detection at Rio 2016 Games
154

Nair V, Miller G, Moore C, Booth M, Beharry A, Fedoruk M, Eichner D:
Observations from hGH biomarker testing in doping control samples – a one year summary
155

Görgens C, Thevis M, Schänzer W, Pop V, Geyer H, Bosse C, Guddat S:
The atypical excretion profile of meldonium: comparison of urinary detection windows after single‐ and multiple‐dose application in healthy volunteers
156

Gavrilović I, Wüst B, Cowan D:
Fast LC‐HRMS Screening by Q‐ToF in Doping Control
157

Polet M, Van Gansbeke W, Van Eenoo P:
Chemical ionization GC‐MS/MS: current developments
158

Geldof L, Deventer K, Verelst C, Van Eenoo P, Ryckx A:
Preventive anti‐doping research of small molecule erythropoiesis stimulating agents: HIF stabilizers
159

Miller G, Nair V, van Wagoner R, Eichner D:
Changes in doping trends following the Designer Anabolic Steroid Control Act of 2014
160

Matabosch X, Coll S, Garrostas L, Monfort N, Pérez‐Mañá C, Mateus J, Ezzel M, de la Torre R, Ventura R, Pizarro N:
Effect of tea consumption on the steroid profil
161

Van Eenoo P, Geyer H, Gmeiner G, Goebel C, Kazlauskas R, Ayotte C:
Booby traps in Doping Analysis
162

Ponzetto F, Boccard J, Randazzo GM, Nicoli R, Kuuranne T, Saugy M, Rudaz S:
Exploring blood steroidomics for the improvement of the steroid profile
163

Sardela V, de Aquino Neto F, Pereira H, de Sousa V, de Carvalho A, Fonseca B, Anselmo C:
Zebrafish: a tool to human‐like metabolism study
164

Thomas A, Knoop A, Schänzer W, Thevis M:
In‐vitro metabolism of small prohibited peptides
165

Piper T, Dib J, Putz M, Fusshöller G, Pop V, Geyer H, Schänzer W, Thevis M:
Studies on the in vivo metabolism of the new SARM YK11 and its implementation into existing doping control methods
166

Geisendorfer T, Göschl L, Benetka E, Gmeiner G:
Monitoring of bacterial activity: increase of Diol concentrations
167

Aguilera R:
Athlete Isotopic Signature or Isotopic Fingerprint of δ13C value
168

Piper T, Thevis M, Schänzer W:
Epiandrosterone sulfate prolongs the detectability of testosterone, 4‐androstenedione, and dihydrotestosterone misuse by means of carbon isotope ratio mass spectrometry
169

Flenker U, Schänzer W:
Use of makeup gas to improve sensitivity and linearity in compound specific analysis of stable hydrogen isotopes
170

Frelat C, Buisson C, Audran M, Martinat N, Mongongu C:
Implementation of AICAR analysis by GC‐C‐IRMS
171

Deventer K, Van Eenoo P, Segura J, Ventura R, Pozo OJ:
Routine application for the open screening of anabolic steroids
172

Mirotti L, Renovato‐Martins M, Du Rocher B, Dudenhoeffer‐Carneiro AC, Pereira HM, Aquino Neto FR:
Homologous blood transfusion doping: Data from Rio 2016 Games and experimental evidences to support interpretation improvement
173

Cox H, Miller G, Lai A, Eichner D: Improved detection of blood doping practices using a dried blood spot method to measure immature reticulocytes
174

Dib J, Tretzel L, Piper T, Schänzer W, Thevis M:
Determination of the AdipoR Agonists AdipoRon, 112254 and their Metabolites in Urine and Dried Blood Spots in Sports Drug Testing
175

Kuuranne T, Jan N, Baume N, Budgett R, Robinson N:
Retesting of anti‐doping samples – joint effort between testing authorities and laboratories
176

Leuenberger N, Rando G, Kuuranne T:
Rapid on‐site detection of gene doping
177

Reichel C, Gmeiner G, Thevis M:
Antibody‐based strategies for the detection of Luspatercept (ACE‐536) in human serum
178

Knoop A, Thomas A, Bidlingmaier M, Delahaut P, Schänzer W, Thevis M:
Detecting corticotropin releasing hormone (CRH) in human blood – two immunoaffinity purification LC‐HRMS/MS approaches for doping control purposes
179

Thomas A, Thevis M, Schänzer W, Delahaut P, Walpurgis K:
Determination of LongR3‐IGF‐I, R3‐IGF‐I, Des1‐3 IGF‐I and their metabolites in human plasma samples by means of LC‐MS
180

Walpurgis K, Thomas A, Dellanna F, Schänzer W, Thevis M:
Detection of the human anti‐ActRII antibody Bimagrumab in serum by means of affinity purification, tryptic digestion, and LC‐HRMS
181

PRESENTATIONS ABSTRACTS ‐ POSTERS

Velasco B, Bautista J, Camacho E, Rodriguez ME, Rodriguez L, Mendoza N:
Screening of Medicaments with Clenbuterol: Enantiomeric Ratio Analysis by HPLC/MS
182

Balgimbekova K, Beksultanova G, Balgimbekov S:
For how long can Clenbuterol be detected in urine after therapeutic and subtherapeutic administration
183

Cho Y, Jeong W, Sung C, Min H, Kim KH, Son J:
Development of MolDES: Molecular Docking Evaluation System for Cocktail Enzymatic Hydrolysis System
184

Jeon M, Lee KM, Cha E, Park J, Lee J, Kwon O, Son J:
Development of CEHS: Cocktail Enzymatic Hydrolysis System for CompleteHydrolysis of Phase II Metabolites of Gestrinone
185

Okano M, Sato M, Kageyama S:
Determination of higenamine in human urine after the administration of a throat lozenge containing Nandina domestica fruit
186

Matabosch X, Pérez‐Mañá C, Pozo OJ, Farré M, Ventura R:
Urinary profiles of prednisolone, prednisone and their metabolites after oral and topical administrations
187

Upadhyay A, Ahi S, Dubey S, Vashisth E, Beotra A, Jain S, Shukla S:
Urinary excretion patterns of Methylprednisolone after oral & intra‐articular administration and effect on endogenous corticosteroids profile
188

Athanasiadou I, Kraiem S, Al‐Sowaidi S, Al‐Mohammed H, Samsam W, Mohamed Ali V, Alsayrafi M, Valsami G, Georgakopoulos C:
Influence of athletes` hyperhydration on the urinary ‘steroid profile’ parameters
204‐205

Nimker V, Jamal H, Jain S, Srivastava A, Sahu K:
Implementation of Steroidal passport: Experiences of Indian Laboratory
206

Quitian G, Barrabini J, Padilha M, Pereira H, Aquino Neto FR:
Evaluation of the endogenous profile of androgenic anabolic steroids in serum of a Brazilian population by GG‐MS/MS
207

Hernández D, Correa Vidal T, Martinez D, Montes de Oca R:
The masking effect of 16β‐OH‐stanozolol on 3’OH‐stanozolol determination in a back up screening procedure
208

Jardines D, de la Torre X, Botrè F:
From normal prior distribution to uniform prior information in the Bayesian evaluation of the isotope ratio mass spectrometric delta values data. A theoretical study
209

Oliveira F, Casilli A, Piper T, Silva T, Silva C, Silva R, Dal Sasso M, Salgueiro G, Padilha M, Pereira H, Thevis M, Aquino Neto FR:
19‐Norandrosterone confirmation by IRMS: Validation and the Olympic experience
210

Mullen J, Hopcraft O, Börjesson A, Ericsson M, Schulze JJ, Ekström L, Lehtihet M:
Longitudinal evaluation of the steroid profile and the isotopic ratio following a single administration of testosterone gel
211

Wang J, Wen C, Liu X:
Steroid Profile and IRMS Analysis on Musk Administration for Doping Control
212

Lee K, Xu YL, Jeong ES, Cha E, Kim HJ, Son J, Kim KH, Park J, Min H, Sung C, Lee J, Kwon O:
Reference ranges of urinary endogenous steroids profile and 13C delta values of Korean population
213

Mäkelä R, Leinonen A, Suominen T:
Screening of doping agents part I: Screening of growth hormone releasing peptides by LC‐TOFMS
214

Esquivel A, Kotronoulas A, Balcells G, Joglar J, Ventura R:
Ionization and collision induced dissociation behavior of steroids bisglucuronides
215

Alechaga E, Monfort N, Ventura R:
Dilute‐and‐shoot UPLC‐MS/MS method for the screening of plasma volume expanders, AICAR, mildronate, ethylglucuronide and hydroxyphenylalkylamines
216

Ohta M, Sato M, Kageyama S, Okano M: Dilute‐and shoot UHPLC/HILIC switching tandem mass spectrometry for urine analysis in doping control
217

Lee J, Jeong ES, Cha E, Lee KM, Kim HJ, Son J, Kim KH, Park J, Min H, Sung C, Kwon O:
Practical and economical online H/D exchange technique using electrospray ionization/ mass spectrometry coupled with gas chromatography
218

Kim KH, Kim Y, Sung C, Min H, Park JH, Son J, Lee KM, Kim HJ, Lee J, Kwon OS:
Development of hybrid sample preparation method using solid phase extraction and diluted urine reconstitution for screening of various classes of prohibited substances by liquid chromatography‐mass spectrometry
219

Cavalcanti G, Rodrigues L, Santos L, Gujar A, Zheng X, Cole J, Padilha M, Aquino Neto F:
Non‐targeted doping‐screening method based on Orbitrap GC/MS: A new perspective
220

Lomen A, Vonaparti A, Abushareeda W, Saad K, Alsayrafi M, Abushareeda P, Nielen M, Georgakopoulos C:
Fast Reprocessing of LC/Q/Exactive Datafiles using MetAlign: A Case Study
221

________________________________________________________________

Manfred Donike Workshop - Proceedings of the 34th Cologne Workshop on Dope Analysis 2016
In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

TABLE OF CONTENTS

LECTURES

Shen L, Zhang L, Yang X, He C, Zhou X, Xu Y, Yan K:
Simultaneous Detection of sixteen WADA prohibited GHRPs, GHS , GnRHs and eight metabolites in human urine by HPLC‐MS/MS
12 ‐ 19 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Pirri D, de la Torre X, Stampella A, Botrè F, Donati F:
A molecular biology‐based indirect strategy for the detection of "induced hypoxia" in blood doping
20 ‐ 25 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Schwenke D:
Application of fluorescence labeled proteins as internal standards for Sarcosyl‐PAGE and Western blot to improved detection of ESAs
26 ‐ 31 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

POSTER PRESENTATIONS

Hernández Domínguez D, Barbán Duarte L, González O, Martínez Brito D, Montes de Oca Porto R:
Interesting increase of nicotine found in urine samples collected in competition during 2015
32 ‐ 36 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Chundela Z, Große J:
Relevance of veterinary β2‐agonists in human doping
37 ‐ 41 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Wu Y, Xing Y, Shen L, Lu J:
Identification of Oxilofrine in Human Urine by LC‐MS/MS
42 ‐ 45 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Singh SP, Dubey S, Kaur T, Beotra A, Jain S, Tomar R:
Detection and quantification of phenethylamine and its derivatives in urine (direct urine injection) and dietary supplements using LC‐MS/MS
46 ‐ 50 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Martínez Brito D, Perez Gutierrez X, Terrero Serrano O, Correa Vidal T, Montes de Oca Porto R:
Influence of an orally administered dexamethasone liposomal preparation on endogenous corticosteroid profiles
51 ‐ 54 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Mazzarino M, de la Torre X, Ughi D:
In vitro investigation of the phase I and phase II metabolism of non‐peptide argininevasopressin‐ V2 receptors antagonists. Selection of the most appropriate marker(s) of misuse.
55 ‐ 60 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Thoerngren J, Ericsson M:
Metabolism study of the selective androgen receptor modulator LGD‐4033
61 ‐ 65 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Zhou X, Shen L, He C, Zhang L:
Longitudinal Study on a Case of Atypical Finding for rhGH
66 ‐ 69 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Agon V, Simpson J, Hall S, Goebel C:
hGH biomarkers screening method by RIA ‐ an unusual result during method validation
70 ‐ 73 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Voss S, Elsaftawy W, Aljaber H, Alsayrafi M, Georgakopoulos C:
Combining immunopurification methods for EPO to improve specificity and avoid double blotting in serum EPO SAR‐PAGE analysis
74 ‐ 78 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Masquelier M, Tollbäck P, Palonek E, Ericsson M:LH detection by AutoDelfia and Vidas 3 immunoassays: total and intact LH comparison in a population of males tested for androgenic anabolic steroid abuse
79 ‐ 82 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Colev JC, Berghes B, Pop V, Zorio M, Tarcomnicu I:
Liquid‐liquid extraction as a simple alternative for the analysis of some of the growth hormone releasing peptides in urine
83 ‐ 87 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Viriyakhasem N, Kaewklum M, Seetapun S, Wilairat P, Chatsiricharoenkul S, Kongpatanakul S:
Preliminary Study: Determination of the basal concentration of di‐(2‐ethylhexyl) phthalates metabolites in urine of Thai population by liquid chromatography tandem mass spectrometry
88 ‐ 91 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

van Renterghem P, Deventer K, van Eenoo P:
Stability of the alternative steroid profile (ASP) Part IV: influence of Exogenous steroids and finasteride on alternative steroid profiles
92 ‐ 96 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Angelis Y, Thomaidis NS, Lympousi K, Tsivou M, Lyris E:
Monitoring of ethylglucuronide in GC‐MS detection method of anabolic androgenic steroids
97 ‐ 100 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Poohribuncha B, Lohwithee S, Kaewklum S, Joengklinjantana N, Pootrakronchai R, Wilairat P, Kongpatanakul S:
Detection of Ethyl Glucuronide (EtG) in Human Urine Using GC‐MS Procedure at NDCC for

Plasma Volume Expander
101 ‐ 103 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Montes de Oca Porto R, Rodriguez Fernandez A, Martínez Brito D, Correa Vidal T, Gonzalez Perez O, Terrero Serrano O:
Isotope ratio mass spectrometric reference intervall data for endogenous steroids in Havana anti‐doping laboratory
104 ‐ 107 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Lalonde K, Ayotte C:
Separating peaks: Controlling the isotopic signature of new IRMS reference materials
108 ‐ 111 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Piper T, Geyer H, Blatt C, Schänzer W, Thevis M:
Hydrogen isotope ratios of urinary norandrosterone ‐ a case study
112 ‐ 115 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Wiriyakosol N, Pootrakronchai R, Inthong T, Panan S, Kusamran T, Wilairat P, Kongpatanakul S:
Experience with LC/MS/MS analysis for routine screening at NDCC
116 ‐ 118 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Zhao J, Yan K, Ma Y, Zhang L, Lv C, Dong Y:
Development and validation of a UPLC‐MS/MS method for the detection of 9 diuretics in human urine
119 ‐ 122 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Mazzarino M, de la Torre X, Botrè F:
Fast LC‐MS/MS screening procedure to detect AICAR, ethanol metabolites and mildronate in human urine for doping control purpose
123 ‐ 127 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Zhang Y, Wang S, Deng J, Liu X, Yang S, Jing J:
The influence of MSTFA derivatised products of Aminoglutethimide by urine matrix
128 ‐ 130 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Walpurgis K, Schultze G, Mareck U, Geyer H, Schänzer W, Thevis M:
Detection of endogenous and pseudoendogenous steroids in dietary supplements containing Rhodiola rosea
131 ‐ 134 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

Krug O, Walpurgis K, Thomas A, Piper T, Sigmund G, Schänzer W, Thevis M:
Black market products with suspiciously doping relevant ingredients – annual report
135 ‐ 139 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (24). Sport und Buch Strauß - Köln 2016 

PRESENTATIONS ABSTRACTS ‐ LECTURES

Guddat S, Görgens C, Steinhart V, Schänzer W, Thevis M:
Mitragynine (Kratom) ‐ monitoring in sports drug testing
140

Dib J, Thomas A, Delahaut P, Fichant E, Schänzer W, Thevis M:
Identification and characterization of in vitro and in vivo generated metabolites of the adiponectin receptor agonists AdipoRon and 112254
141

Rzeppa R, Viet LN, Dehnes Y:
Investigations of vaptan metabolism, exemplified with tolvaptan
142

Rossi F:
The Universe beyond the laboratories
143

Parr MK, Wüst B, de la Torre X, Nägele E, Stanic M, Schmidt AH, Botrè F:
Supercritical Fluid Chromatography (SFC) as Orthogonal Technique for Improved Detection of Polar Analytes in Anti‐Doping Control
144

Görgens C, Guddat S, Thomas A, Wachsmuth P, Orlovius A, Sigmund G, Thevis M, Schänzer W:
Simplifying and expanding analytical capabilities for various classes of polar and non‐polar doping agents by means of direct urine injection high resolution/high accuracy mass spectrometry
145

Sardela V, Martucci ME, de Araújo A, Leal E, Oliveira D, Carneiro G, Pereira HM, de Aquino Neto F:
Comprehensive analyses by liquid chromatography‐Q‐orbitrap mass spectrometry: fast screening of peptides and small molecules
146

Thomas A, Görgens C, Guddat S, Thieme D, Dellanna F, Schänzer W, Thevis M:
Simplifying and expanding the screening for peptides < 2 kDa by means of direct urine injection, liquid chromatography and ion mobility‐mass spectrometry
147

Buisson C, Marchand A, Bailloux I, Lahaussois A, Martin L, Molina A:
HIF stabilizer drug FG‐4592 used as a new doping agent by athletes: investigation on a positive case
148

Knoop A, Thomas A, Fichant E, Delahaut P, Schänzer W, Thevis M:
Qualitative identification of growth hormone releasing hormones in human plasma by means of immunoaffinity purification and LC‐HRMS/MS
149

Tretzel L, Thomas A, Piper T, Hedeland M, Geyer H, Schänzer W, Thevis M:
Fully automated determination of nicotine and its major metabolites in whole blood by means of a DBS online‐SPE LC‐HR‐MS/MS approach for sports drug testing
150

Abushareeda W, Vonaparti A, Kraiem S, Saad K, Alwahaibi A, Almansoori M, Meloug M, Saleh A, Alyazedi S, Dbes N, Khalil A, Wuest B, Reiner J, Alsayrafi M, Georgakopoulos C:
Preventive doping control analysis: liquid and gas chromatographic high resolution full scan mass spectrometric initial testing procedure for small molecules
151

Geldof L, Deventer K, Tudela E, van Eenoo P:
In vitro metabolism studies of REV‐ERBα agonists SR9009 and SR9011
152

Gavrilovic I, Galesio M, Cowan D:
Simplifying analysis of novel SARMs – the power of in vitro metabolism with tandem high resolution mass spectrometry
153

Ayotte C, Morneau É, Charlebois A, Arsenault A, Lalonde K:
Trends in Detectable Doping Substances in International Events
154

van Renterghem P, Deventer K, Lootens L, van Eenoo P:
Detection of the long‐acting testosterone formulation Nebido® and influence on blood and steroid profile values
155

Ayotte C, Charlebois A, Trudel M:
Evaluation of individual athlete’s steroid profiles
156

Ponzetto F, Mehl F, Boccard J, Baume N, Rudaz S, Saugy M, Nicoli R:
Longitudinal follow‐up of endogenous steroids in serum: a first step towards “steroid profile” in blood
157

Matabosch X, Sergi C, Garrostas L, Pérez‐Mañá C, Ventura R:
Effect of glucocorticoid administration on the steroid profile
158

Polet M, van Gansbeke W, van Eenoo P:
GC‐CI‐MS/MS analysis of anabolic androgenic steroids
159

Balcells G, Matabosch X, Garrostas L, Gomez C, Pozo OJ, Esquivel A, Ventura R:
Detection, evaluation and characterization of new steroid sulfate metabolites
160

Okano M, Sato M, Kageyama S:
Mass spectrometric characterization of EPO biosimilar products
161

Vogel M, Thomas A, Schänzer W, Thevis M:
Analytics of non‐peptide erythropoietin mimetic agents by means of high resolution / high accurate LC‐MS/MS determination
162

Casilli A, Piper T, Oliveira F, Padilha M, Pereira HM, Thevis M, de Aquino Neto FR:
Optimization of an on‐line heart‐cutting multidimensional gas chromatography clean‐up step for IRMS and simultaneous quadrupole MS measurements of endogenous anabolic steroids in urine
163

Jardines D, Colamonici C, Molaioni F, Curcio D, Botrè F, de la Torre X:
Longitudinal evaluation of the isotope ratio mass spectrometric data
164

Hülsemann F, Lehn C, Schneiders S, Jackson G, Hill S, Rossmann A, Scheid N, Dunn PJH, Flenker U, Schänzer W:
Global spatial distribution of human carbon isotope ratios
165

Flenker U, Riemann P, Schänzer W:
Towards an Integration of Steroid Profiling and Stable Isotope Analysis
166

Riemann P, Macha A, Schult C, Gougoulidis V, Haenelt N, Fußhöller G, Flenker U, Schänzer W:
Effects of the Female Menstrual Cycle, Hormonal Contraception, and Pregnancy on Profiles and 13C/12C Ratios of Endogenous Steroids
167

de la Torre X, Colamonici C, Curcio D, Botrè F:
High throughput IRMS analysis
168

Nair V, Miller G, Morrison S, Summers M, Willick S, Eichner D:
Intranasal Delivery of Natesto Testosterone Gel and Its Effect on Doping Markers
169

Piper T, Schänzer W, Thevis M:
Metabolism of exogenous testosterone in UGT2B17 del/del genotype
170

Butch A:
Human Chorionic gonadotropin (hCG) isoform concentrations in doping control samples considered negative, positive and atypical
171

Salamin O, Barras L, Barelli S, Lion N, Robinson N, Baume N, Tissot J, Saugy M, Pitsiladis Y, Leuenberger N:
Digital multiplex mRNA profiling for the detection of autologous blood transfusion in sports ‐ a pilot study
172

Miller G, Eichner D, Cushman D, Teramoto M:
Evaluating Dehydration in the Context of the Biological Passport
173

Giraud S, Weber C, Baume N:
Human Growth Hormone biomarkers: Validation and first results on Swiss Athlètes
174

Ferro P, Ventura R, Pérez‐Mañá C, Farré M, Segura J:
Potential new genetic and protein biomarkers for the improved detection of GH abuse
175 ‐ 176

Reichel C, Farmer L, Thevis M, Lorenc B:
Detection of Sotatercept in human serum by sarcosyl ployacrylamide gel electrophoresis
177

Walpurgis W, Thomas A, Reichel C, Vogel M, Schänzer W, Thevis M:
Detection of the erythropoiesis‐stimulating agent Sotatercept (ActRIIA‐Fc) in serum by means of western blotting and LC‐HRMS
178

PRESENTATIONS ABSTRACTS ‐ POSTERS

Kwiatkowska D, Liebetrau F, Schmidt AH, Stanic M, Blokland MH, Meijer T, Waraksa E, Sterk SS, Parr MK:
Determination of Clenbuterol enantiomers in a controlled administration trial for distinction of food contamination and drug abuse
179

Perrenoud L, Schweizer C, Nicoli R, Baume N, Saugy M:
Risk of false positive results to SARM S4 in case of therapeutic use of antineoplastic/antiandrogen drug containing flutamide: a study case
180

Okano M, Sato M, Ohta M, Kageyama S:
Case report: Trimetazidine produced by metabolic conversion of lomerizine.
181

Görgens C, Guddat S, Dib J, Wachsmuth P, Geyer H, Schänzer W, Thevis M:
Mildronate (Meldonium) in professional sports – monitoring of doping control urine samples
182

Dib J, Sigmund G, Tretzel L, Piper T, Bosse C, Schänzer W, Thevis M:
Monitoring 2‐phenylethanamine and 2‐(3‐hydroxyphenyl)acetamide sulfate in doping controls
183

Thomas A, Brinkkötter P, Schänzer W, Thevis M:
Strategies to uncover the administration of recombinant human insulin by LCHRMS
184

He C, Zhou X, Zhang L, Shen L, Liu X, Yang X, Feng F, Xu Y:
Statistic Analysis of Urinary Total LH Level of Chinese Male Athletes
185

Cuervo D, Loli C, Muñoz G, Aguilera R:
Screening and Confirmation of Doping‐related Peptides via Accurate‐Mass Quadrupole Time of‐Flight (Q‐TOF) LC/MS
186

Ohta M, Sato M, Kageyama S, Okano M:
Doping control analysis of small peptides in human urine by microfluidic chromatography/tandem mass spectrometry
187

Weber C, Baume N:
Luteinizing hormone content in urine samples of Swiss athletes during routine doping controls
188

Kniess A, Thieme D:
High‐sensitive Method for the Detection of Growth Hormone Releasing Peptides using Strata X Drug B Cartridges for Sample Preparation
189

Kniess A, Groba D, Grosse J, Thieme D:
Pharmacokinetic and Pharmacodynamic Aspects of an Application of recombinant Human Chorionic Gonadotropin (OVITRELLE)
190

Martin L, Ashenden M, Lasne F, Marchand A:
New insights for identification of doping with EPO micro‐doses
191

Okano M, Sato M, Kageyama S:
Differentiation of PEGylated and non‐PEGylated erythropoietins using LC‐MS/MS with Insource CID
192

San Román I, Saratxaga A, Alonso RM, Bartolomé L, Ventura R, Segura J, Monfort N:
Determination of the volatile metabolites of the plasticizer di(2‐ethylhexyl) phthalate in urine by MHS‐SPME‐GC/MS as possible markers for blood transfusion in sports drug testing
193

Charlebois A, Desjardins M, Ayotte C:
Improved Confirmation of Dehydrochlormethyltestosterone long‐term Metabolite on the Agilent 7010 Triple Quadrupole GC‐MS.
194

Esquivel A, Pozo OJ, Garrostas L, Balcells G, Kotronoulas A, Joglar J, Ventura R:
LC‐MS/MS Strategies for the direct detection of glucuronide metabolites of metandienone
195

Ayotte C, Sylvestre A, Poirier D, Charlebois A:
Detection of 5α‐androst‐2‐en‐17‐one and variants in athletes’ samples
196

Tretzel L, Thomas A, Geyer H, Pop V, Schänzer W, Thevis M:
Dried blood spots (DBS) in doping controls: a complementary matrix for improved in‐ and out of competition sports drug testing strategies
197

Schönfelder M, Hofmann H, Schulz T, Engl T, Kemper D, Rautenberg C, Oberhoffer R, Thieme D:
Potential Detection of Low Dose Transdermal Testosterone Administration in Blood, Urine and Saliva
198

Yan K, Xu Y, Liu X, Dong Y:
Preliminary study of the impact on steroid profile after oral administra‐tion of desmopressin
199

Jarek A, Wójtowicz M, Chajewska K, Szczepanska Z, Wójcikowska‐Wójcik B, Zalewska Z, Turek‐Lepa E, Kwiatkowska D:
Influence of single ethanol dose administration on endogenous steroids levels in human urines
200

Rzeppa S, Viet LN, Dehnes Y:
Analysis of phase II metabolites by high performance liquid chromatography coupled to tandem mass spectrometry
201

Kim KH, Kim Y, Lee J, Son J, Kim HJ, Lee KM, Park J, Min H, Kwon O:
High‐speed narcotics and cannabinoids screening by ‘dilute‐and‐shoot’ strategy using a highresolution mass spectrometry for enhanced selectivity
202

Lee J, Jeong ES, Cha E, Kim KH, Kwon O, Cha S:
Direct quantitative analysis of prohibited threshold substances by paper spray ionization mass spectrometry
203

Nicoli R, Desfontaine V, Novakova L, Ponzetto F, Veuthey J, Guillarme D, Saugy M:
Fast and sensitive screening of anabolic agents in urine samples by UHPSFCMS/MS and UHPLCMS/MS: a comparison study
204

Nicoli R, Novakova L, Grand‐Guillaume Perrenoud A, Veuthey J, Guillarme D, Saugy M:
UHPSFC‐ESI‐MS/MS: a powerful analytical platform for screening of doping agents in urine by ‘dilute‐and‐shoot’
205

Balcells G, Matabosch X, Monfort N, Ventura R:
Dilute‐and‐shoot multi‐screening method of doping agents in human urine using a LC‐QTOF instrument
206

van Eenoo P, van Gansbeke W, Polet M, Roels K, Deventer K:
Detection of a new beta‐2‐agonist, higenamine, present in supplements
207

Weber C, Krug O, Kamber M, Thevis M:
Analysis of 1'078 black market products seized at the swiss border
208

Wójtowicz M, Jarek A, Chajewska K, Waraska E,2, Szczepańska Z, Kwiatkowska D:
Anabolic agents and stimulants present in supplements from Polish market
209

Wójtowicz M, Jarek A, Chajewska K, Stanczyk D, Tarka M, Kwiatkowska D:
Elimination study of NN‐DPPA ‐ urine determination by GC‐MS system
210

Thevis M, Krug O, Piper T, Geyer H, Schänzer W:
Quantification of undeclared ionic cobalt and nickel in products advertised with erythropoiesisstimulating properties
211 

_______________________________________________________________

Manfred Donike Workshop - Proceedings of the 33rd Cologne Workshop on Dope Analysis 2015
In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015  

TABLE OF CONTENTS

LECTURES

Mazzarino M, de la Torre X, Khevenhüller F, Iannone M, Palermo A, Botrè F:
Effects of antifungals on the circadian fluctuation of the markers of the “steroid profile”. An in vivo study
13‐18 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Sobolevsky T, Dudko G, Rodchenkov G:
Improved detection of steroid sulfate conjugates using LC‐MS/MS with paired‐ion electrospray (PIESI) ionization
19‐25 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Sobolevsky T, Rodchenkov G:
Detection of epitrenbolone glucuronide and cysteinyl conjugate of trenbolone may provide better retrospectivity of trenbolone abuse
26‐32 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Beotra A, Dubey S, Kaur T, Singh A, Yadav S, Jain S:
Best practices for running a PT program as per ISO/IEC 17043:2010 standard: Accreditation of NDTLPT Scheme.
33‐36 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Ouellet A, Lalonde K, LeBerre N, Séguin F, Ayotte C:
Two‐dimensional purification of low concentration analytes in urine for carbon isotope ratio analysis 3
7‐44 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

POSTER PRESENTATIONS

de Paolis E, de la Torre X, Mazzarino M, Botrè F:
Relevance of cyclodextrins on the doping control field: potential masking effects and their detection in biological fluids
45‐50 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Dong Y, Ma Y, Yan K, Xu Y:
Determination of mannitol in human urine by LC‐MS/MS for sports drug testing
51‐53 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Nimker V, Jamal H, Lal R, Ghosh PC, Jain S, Beotra A:
Liposomes: Factors affecting interaction of liposomes with doping agents
54‐58 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Upadhyay A , Dubey S , Dubey S , Priyadarshi R , Beotra A , Shukla S , Jain S:
A preliminary study on the endogenous glucocorticoids profile in human urine by UPLC‐MS/MS: Effect of synthetic glucocorticoids.
59‐63 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Sobolevsky T, Dikunets M, Rodchenkov G
Metabolism study of GSK4112, SR9009, and SR9011, new “exercise‐in‐a‐pill” drug candidates
64‐69 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Mazzone R, Botrè F, Capodaglio M, de la Torre X, Fiacco I, Mazzarino M:
An in vitro investigation on the phase I and phase II metabolism of aminoalkylindoles. Selection of the most appropriate marker(s) of misuse.
70‐74 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Sobolevsky T, Dikunets M, Dudko G, Rodchenkov G:
Metabolism study of the selective androgen receptor modulator LGD‐4033
75‐79 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Sobolevsky T, Dikunets M, Rodchenkov G:
Newcomers to the synthetic cannabinoid family: detection of major metabolites in urine
80‐83 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

He C, Shen L, Zhang L, Zhou X, Xu Y:
Comparison of five immunoassays for the detection of human chorionic gonadotropin
84‐87 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Zhou X, Zhao Y, He C, Xu Y, Wu M:
Serum MiRNAs as the Potential Biomarker for Doping Analysis of Steroids
88‐91 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

He C, Wu M, Hu Y, Zhou X, Shen L, Zhang L, Xu Y:
Circulating microRNAs as biomarkers of human growth hormone administration: microassay analysis
92‐94 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Cocchiola C, Botrè F, de la Torre X, Mazzarino M:
Detection of intact insulins in biological fluids by LC‐ESI‐MS/MS following protein precipitation, ultra filtration and immunoaffinity chromatography purification.
95‐100 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Castro JL, Martucci MEP, dos Santos GR, Carneiro GR, da Costa GC, Sardela VF, Pereira HM, Aquino Neto FR:
Peptides in doping control: screening, confirmation, validation protocols and stability results
101‐106 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Parrotta G, Botrè F, de la Torre X, Mazzarino M:
A multi‐analyte procedure to detect small peptides in urine by LC‐MS/MS following solid phase extraction.
107‐113 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Donati F, Conte C, Tonelli F, Stampella A, Pirri D, de la Torre X, Botrè F:
Effects of local injections of platelet rich plasma (PRP) on serum levels of markers used for the detection of growth hormone doping
114‐117 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Rodrigues Tavares AS, Ruivo J, Montes de Oca Porto R, Martínez Brito D, Torres M:
Characteristics of IEF Patterns, SDS‐PAGE and SAR‐PAGE: Result of Cuban rEPO Biosimilar
118‐121 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Desharnais P, Chapot R, Naud J, Ayotte C:
Comparative study of the EPO‐immunoaffinity approaches used for anti‐doping control purposes.
122‐125 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Tretzel L, Thomas A, Sköld K, Zeeberg D, Schänzer W, Thevis M:
Improvement of the stability of Synacthen® in Dried Blood Spots by means of heat stabilization
126‐129 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Tangvisethpat C, Grainger J, Goebel C, George AV:
Comparison of low volume quantifiable blood sampling kits
130‐134 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Pereira L, Ramos S, Paixão P, Horta L, Ruivo J:
Is the strategy of Biological Passport changing the behaviour of elite athletes in Portugal?
135‐138 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Okano M, Ikekita A, Kageyama S:
Steroid profiles and alcohol marker ethyl glucuronide in Japanese athletes
139‐143 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Forsdahl G, Johnsgaard T, Geisendorfer T, Kainzbauer J, Gmeiner G:
Evaluation of the influence of grapefruit juice on the endogenous urinary steroid profile
144‐147 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Sobolevsky T, Dikunets M, Dudko G, Rodchenkov G:
3‐Oxo‐4‐azasteroids with purported anabolic activity: detection in urine and influence on steroid profile
148‐151 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Zorio M, Pop A, Danila M, Pop V:
Development and validation of a method for steroid profile using gas chromatography coupled to triple quadrupole mass spectrometry
152‐156 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

LeBerre N, Lalonde K, Ouellet A, Séguin F, Ayotte C:
From cleanup and analysis to data compilation: carbon isotope ratio determination of 19‐norandrosterone origin in athlete’s urine samples
157‐160 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Dong Y, Yan K, Ma Y, Wang S:
An improved LC‐MS/MS method to quantify ephedrines in human urine and elimination of the matrix effects
161‐164 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Yan K, Ma Y, Shen L, Xu Y, Dong Y:
Confirmation of furosemide, hydrochlorothiazide and ACB in human urines by LC‐MS/MS with full or product ion scan mode
165‐168 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Balgimbekova K, Nurpeisov N, Talbaev T:
A simple quantification and confirmation of 11‐nor‐Δ9‐tetrahydrocannabinol‐9‐carboxylic acid (THCCOOH) in urine by liquid chromatography coupled to high resolution Orbitrap mass spectrometry analysis.
169‐172 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Wicka M, Chołbiński P, Kowalczyk K, Grucza K, Michalak D, Stańczyk D, Kwiatkowska D:
Detection of synthetic cannabinoids in urine by LC/MS/MS
173‐177 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Esquivel A, Balcells G, Pozo OJ, Gómez C, Kotronoulas A, Joglar J, Segura J, Ventura R:
New LC‐MS/MS screening for methyltestosterone: direct detection of phase I and phase II metabolites in urine
178‐182 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Georgakopoulos C, Mikros E, Fragkaki AG, Kostidis S, Tsantili‐Kakoulidou A, Moumouzas J, Lyris E:
Screening of designer steroids by NMR/Pattern recognition
183‐188 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Pootrakronchai R, Inthong T, Kaewklum M, Saardpun N, Panan S, Kusamran T, Kongpatanakul S:
Method validation for routine screening of 145 WADA prohibited substances by LC‐MS/MS
189‐191 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Chołbiński P, Wicka M, Kowalczyk K, Grucza K, Michalak D, Stańczyk D, Kwiatkowska D:
Discrimination of phenyl ring positional isomers of methylmethcathinone by LC/MS/MS
193‐196 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Kazlauskas R, Goebel C:
Androst‐3,5‐diene‐7,17‐dione in supplements and its urinary metabolite
197‐200 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Krug O, Thomas A, Walpurgis K, Piper T, Sigmund G, Schänzer W, Thevis M:
Mass spectrometric analysis of black market products with suspiciously doping relevant ingredientsby HPLC‐(HR)MS, GC‐(HR)MS, ICP‐MS, and 1D‐gel electrophoresis‐UPLC‐MSn
 201‐205 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Kaewklum M, Kaewklum S, Pootrakronchai R, Kusamran T, Wilairat P, Chatsiricharoenkul S, Kongpatanakul S:
Incidence of Mitragynine from urine samples at NDCC, Bangkok.
206‐209 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Sobolevsky T, Dikunets M, Rodchenkov G:
Use of meldonium (Mildronate) and emoxypine (Mexidol) by Russian athletes: a prevalence study
210‐213 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Sobolevsky T, Dikunets M, Rodchenkov G:
Identification of an unknown compound with claimed HIF activity in a black market product
214‐219 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

Cuervo D, Martín‐Navas P, Saavedra MJ, García L, Aguilera R:
An overview of doping‐related arrests in Spain during 2014: statistics and analysis conducted by the Doping Control Laboratory in Madrid
220‐223 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (23). Sport und Buch Strauß - Köln 2015 

PRESENTATIONS ABSTRACTS ‐ LECTURES

Piper T, Thevis M, Geyer H, Schäfer M, Kienbaum PSchänzer W:
Measuring xenon in blood and urine for doping control purposes
224

Agon VV, Simpson J, Hall S, Goebel C:
An unusual case of a plasma volume expander ? Dextran (?)
225

Dib J, Schlörer N, Schänzer W, Thevis M:
Studies on the Collision?Induced Dissociation of adipoR Agonists After Electrospray Ionization and Their Implementation in Sports Drug Testing
226

Tsivou M, Giannadaki E, Georgakopoulos D, Van Eenoo P, Hooghe F, Van Gansbeke W, Botre F, de
la Torre X, Mazzarino M, Donati F, Lyris E, Georgakopoulos C:
Optimization of the synthesis of the chemical stabilization mixture of urine samples with simultaneous minimization of analytical matrix interferences
227-228

Görgens C, Guddat S, Orlovius AK, Sigmund G, Thomas A, Thevis M, Schänzer W:
“Dilute-and-Inject” multi-target screening assay for highly polar doping agents using hydrophilic interaction liuid chromatography high resolution/high accuracy mass spectrometry (HILIC/HRMS) for sports drug testing.
229

Guddat S, Görgens C, Dib J, Geyer H, Schänzer W, Thevis S:
Mildronate (Meldonium) in professional sports – monitoring doping control urine samples using hydrophilic interaction liquid chromatography ‐ high resolution / high accuracy mass spectrometry
230

Goebel C, Grainger J, Clarke E:
My Robot II: the next step in automation.
231

Ventura R, Metabosch X, Monfort N, Pozo OJ, Monfort J, Llorente‐Onaindia J, Segura J:
Urinary profiles of corticosteroids after intra‐articular and related administrations
232

Tretzel L, Thomas A, Geyer H, Delahaut P, Schänzer W, Thevis M:
Determination of Synacthen® in Dried Blood Spots for doping control analysis using liquid chromatography tandem mass spectrometry
233

Athanasiadou I, Valsami G, Voss S, Kraiem S, Vonaparti A, El Saftawy W, Al Saadi K, Alwahaibi A, Aljaber A, Dokoumetzidis A, Muhammad‐Ali V, Adel A, Alsayrafi M, Georgakopoulos C:
Influence of athletes´ hyperhydration on sample collection procedure in terms of urine pharmacokinetics of representative prohibited substances
234‐235

Polet M, Van Gansbeke W, Hooghe F, Van Eenoo P:
Increasing the sensitivity of gas chromatography – triple quadrupole mass spectrometry by using chemical ionization.
236

Nair V, Cox H, Campbell T, Eichner D:
Tracing adverse analytical findings to mislabeled underground products
237

Geldof L, Lootens L, Tudela E, Morthier W, Deventer K, Van Eenoo P:
In vitro metabolism studies of black market products
238

Lootens L, Geldof L, Meuleman P, Leroux‐Roels G, Botrè F, Deventer K, Van Eenoo P:
Metabolic study of methyldienolone, methyltrienolone and MENT using human liver microsomes and humanized mice.
239

de la Torre X, Rosati L, Curcio D, Colamonici C, Molaioni F, Jardines D, Botrè F:
Mass spectrometric analysis of androstenedione in doping analysis.
240

Gmeiner G, Forsdahl G, Tretzel L, Thevis M, Geisendorfer T, Erceg D:
 Detection of testosterone esters in blood samples
241

Jan N, Michelot H, Marclay F, Esseiva P, Saugy M:
Profiling of customs seized drugs containing testosterone
242

Rzeppa S, Heinrich G, Humpf H, Hemmersbach P:
Analysis of anabolic androgenic steroids as sulfate metabolites using liquid chromatography coupled to tandem mass spectrometry
243

Balcells G, Pozo OJ, Esquivel A, Gómez C, Segura J, Rosa V:
Towards a more comprehensive and simple method to screen for exogenous anabolic steroids in sport
244

Van Renterghem P, Esposito S, Deventer K, Van Eenoo P:
Stability of the alternative steroid profile (ASP)
Part III: influence of ACTH and corticosteroids on alternative steroid profiles
245

Brooker L, Edey C, Medojevic N, Tjoa J, Goebel C:
Recent trends in “workplace” AAS testing at the Australian Sports Drug Testing Laboratory (ASDTL).
246

Höppner S, Thomas A, Sander M, Opfermann G, Dib J, Schänzer W, Thevis M:
Complementing the characterization of in vivo generated N‐glucuronic acid conjugates of stanozolol by collision cross section computation and analysis
247

Piper T, Schänzer W, Thevis M:
Investigation and reconsideration of the 19‐nortestosterone metabolism
248

Flenker U, Riemann P, Hülsemann F, Gougoulidis V, Haenelt N, Braun H, Köhler K, Mester J, Schänzer W:
Still more physiological Effects on stable Isotope Ratios of endogenous Steroids
249

Riemann P, Hülsemann F, Gougoulidis V, Fußhöller G, Haenelt N, Schult C, Macha A, Schänzer W, Flenker U:
Effects of reduced energy‐uptake on concentrations and 13C/12C ratios of urinary steroids – a case study
250

de la Torre X, Procida G, Curcio D, Colamonici C, Jardines D, Molaioni F, Botrè F:
Stability of endogenous steroids IRMS data. An additional tool for longitudinal investigations.
251

Leuenberger N, Barras L, Nicoli R, Lion N, Barelli S, Tissot JD, Saugy M:
Detection of autologous DEHP‐free blood transfusion
252

Kuuranne T, Alfthan H, Leinonen A, Stenman UH:
Development of standardized methods for determination of hCG in urine
253

Dehnes Y, Schulze J, Myrvold L, Holden G, Drange M:
4 years of longitudinal profiles of GH‐biomarkers of Norwegian elite athletes
254

Walpurgis K, Thomas A, Schänzer W, Thevis M:
Myostatin inhibitors in sports drug testing: Detection of myostatin‐neutralizing antibodies in plasma/serum by affinity purification and Western blotting
255

Thomas A, Walpurgis K, Brinkkötter P, Delahaut P, Schänzer W, Thevis M:
Expanded test method for peptides >2 kDa employing immunoaffinity purification and LC‐HRMS/MS
256

Ferro P, Krotov G, Zvereva I, Rodchenkov G, Segura J:
Insight into the GHSR1a activity in urine after nasal administration of 500 μg of GHRP‐1, GHRP‐2, GHRP‐6, Hexarelin and Ipamorelin
257‐258

Krotov G, Zvereva I, Ferro P, Semenistaya E, Filatov A, Segura J, Rodchenkov G:
Purification and analysis of Growth Hormone Secretagogues and its biologically active metabolites by cell membrane‐based receptor binding followed by LC‐MS/MS
259

Krotov G, Postnikov P, Mesonzhnik N, Efimova Y, Rodchenkov G:
Strategies of EPO‐Fc fusion protein detection by means of IEF‐PAGE and LC‐MS/MS
260‐261

Zhang L, He C, Xu Y:
Detection of lanthandies tagged monoclone antibody of erythropoietin by Inductive Coupled Plasma Mass Spectrum (ICP‐MS)
262

Gmeiner G, Benetka W, Passet C, Reichel C:
News from GASepo
263

Vogel M, Thomas A, Schänzer W, Thevis M:
Detection of Erythropoietin Mimetic Peptide‐Based Drugs from Human Urine by means of EPORpurification and LC/MS/MS determination
264

PRESENTATIONS ABSTRACTS ‐ POSTERS

Kojima A, Okano M, Dohi M, Kageyama S:
Analysis of polysaccharides dextran and hydroxyethylstarch in dried blood spot and urine
265

Sardela VF, Scalco FB, Cavalcante KM, Simoni RE, Pereira HM, Maria Lucia Cd, Aquino Neto FR:
Fast doping analysis for glycerol
266

Deventer K, Cooman H, Van Eenoo P:
Screening and confirmation of a glycerol‐positive urine sample.
267

Okano M, Nishitani Y, Kageyama S:
Influences of intravenous infusion of glycerol on urinary glycerol concentrations and blood parameters
268

Chundela Z, Große J:
Olodaterol and vilanterol detection in sport drug testing
269

Tretzel L, Sigmund G, Dörries L, Piper T, Schänzer W, Thevis M:
Urinary phenylethylamine in sports drug testing
270

Knoop A, Krug O, Vincenti M, Schänzer W, Thevis M:
In vitro metabolism studies and LC‐MS characterization of SARM LG121071 for routine doping control
271

Nikitina M, Zhuravleva M, Krotov G, Rodchenkov G:
Serum microRNA profiling by HiSeq1500 after rEPO administration
272

Kishikawa Y, Otsuki T, Kawahara T, Ueki M:
Novel methods for identification of recombinant glycoprotein hormones
273

Mesonzhnik N, Krotov G, Rodchenkov G:

Identification of a new insulin mimetic compound S597 in the preparation available via Internet 274

Reihlen P, Blobel M, Völker‐Schänzer E, Schänzer W:
Quick stripping procedure for the reduction of artefacts during EPO analysis
275

Zvereva I, Semenistaya E, Krotov G, Rodchenkov G:
Effectiveness of various in vitro model systems for the prediction of the small biologically active peptide metabolites
276

Semenistaya E, Zvereva I, Krotov G, Rodchenkov G:
High throughput sample preparation for analysis of small biologically active peptides from human urine
277

Kempkes R, Romberg S, Reihlen P, Schänzer W:
High‐throughput screening for the detection of homologous blood transfusion
278

Georgakopoulos C, Alsaadi K, Voss S, El Saftawy W, Dbes N, Goebel RT, Alsowaidi S,Seyam AM, Bashraheel AS, Mohamed‐Ali V, Alsayrafi M:
The effect of fasting during Ramadan on parameters of the hematological module of the Athletes Biological Passport – A pilot study
279

Georgakopoulos C, Alsaadi K, Voss S, Kraiem S, Alwahaibi A, Alyazedi S, Dbes N, Goebel RT, Mohamed‐Ali V, Alsowaidi S, Seyam AM, Bashraheel AS, Alsayrafi M:
The effect of fasting during Ramadan on Steroid Profile ABP Parameters ‐ A pilot study
280

Kishikawa Y, Otsuki T, Kawahara T:
Quality management of blood analysis for the Athlete Biological Passport inmobile testing unit ‐ System construction examples‐
281

Nicoli R, Ponzetto F, Baume N, Saugy M:
Quantification of endogenous steroids in human serum by UHPLC‐MS/MS
 282

Brooker L, Edey C, Huynh T, Goebel C:
Steroid profiling for the Asian Football Cup 2015
283

Ristimaa J, Rautava K, Leinonen A:
Evaluation of the athlete urinary steroid profiling data – first year experience
284

Mullen J, Ericsson M, Schulze J, Ekström L
The effect of emergency contraceptives and menstrual cycle on the steroid
285

Rzeppa S, Viet LN, Humpf H, Hemmersbach P:
Excretion of oxandrolone metabolites in the sulfate fraction
286

Wang J, Yang R, Zhang J, Liu X, Xing Y, Xu Y:

Excretion study on boldenone for doping control
287

Lee J, Cha EJ, Kim SH, Kim HW, Kim HJ, Kwon OS:
Sensitivity of anabolic steroids based on GC‐EI/MS, GC‐EI/MS/MS, LC‐ESI/MS/MS, LC‐Ag+CIS/MS/MS and GC‐ESI/MS/MS in doping control analysis
288

Strahm E, Mullen J, Schulze J, Ericsson M, Ekström L:
Dose dependent testosterone sensitivity of the steroid passport and IRMS analysis in relation to the UGT2B17 deletion polymorphism
289

Curcio D, Colamonici C, Molaioni F, de la Torre X, Botrè F:
Use of the ESA‐analysis ultrafiltrate for GC‐C‐IRMS: a new frontier?
290

Cilia M, Curcio D, Colamonici C, Molaioni F, Jardines D, de la Torre X, Botrè F:
Detection of urinary glucocorticoids metabolites by gas chromatography‐isotope ratio mass spectrometry in doping control.
291

Brailsford A, Walker C, Wojek N, Foxton S, Cowan D:
Targeting Samples for GC‐C‐IRMS Analysis: evaluation of USP data.
292

Monfort N, Fabregat A, Pozo O, Segura J, Ventura R:
Fast screening for ß‐blockers in urine based on the detection of the parent drugs, and phase I and phase II metabolites by UHPLC‐MS/MS
293

De La Cruz MN, Gonçalves P, Sardela VF, Pereira HM, Aquino Neto FR:
Optimization in ephedrines dilute‐and‐shoot quantification methods
294

Saad K, Vonaparti A, Alsayrafi M, Georgakopoulos C:
 Anabolic steroids sensitive confirmatory methods based on LCMSMS analysis of underivatised and derivatised analytes of metabolites
295

Abushareeda W, Kraiem S, Alwahaibi A, Alsayrafi M, Georgakopoulos C:
 GCQTOF Full‐Scan High Resolution Screening
296

Abushareeda W, Vonaparti A, Saad K, Almansoori M, Aljabiry A, Meloug M, Alsayrafi M, Georgakopoulos C:
LC Q‐Exactive Full‐Scan High Resolution MS Generic Screening
297

Hullstein I, Malerod‐Fjeld H, Hemmersbach P:
Black market products in Norway
298

Thorngren J, Ericsson M:
β‐methylphenetylamine, a new stimulant on the Swedish market.
299

Baume N, Jan N, Robinson N, Dvorak J, Saugy M:
Anti‐doping program and biological monitoring during the 2014 FIFA World Cup BrazilTM
300

Velasco B, Camacho E, Rodriguez L, Rodriguez M, Reynoso E, Godinez M, Mercado K, Quintero I:
Experience of the doping laboratory Mexico at the Central American and Carribean Games Veracruz 2014
301

Pascual JA, Civit E, Farré M, Pérez‐Maña C, Segura J, de la Torre R:
Impact of the ingestion of low doses of alcohol on the steroid profile. The PROFETHYL Study.
302 

________________________________________________________________

Manfred Donike Workshop - Proceedings of the 32nd Cologne Workshop on Dope Analysis 2014
In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

TABLE OF CONTENTS

LECTURES

Trout G, Grainger J, Goebel C:
My Robot: can complete automation of sample preparation be achieved?
11 - 17 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Rzeppa S, Beeck M, Malerod-Fjeld H, Humpf H, Hemmersbach P:
High-throughput screening method for glycerol in urine using a “dilute-and-shoot” liquid chromatography-tandem mass spectrometry approach
18 - 21 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Fiacco I, Botrè F, Capodaglio M, de la Torre X, Mazzarino M:
Characterization of the main biotransformation pathways of synthetic cannabinoids from different chemical classes
22 - 29 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Van Renterghem P, Van Eenoo P:
Stability of the alternative steroid profile and stereodomic model: Part II –Evaluation of female steroid profiles: influences of contraceptives and pregnancy
30 - 35 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Esposito S, Deventer K, Geldof L, Van Eenoo P:
Doping control analysis of small peptide hormones: an update
36 - 41 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Mazzarino M, Alessi B, de la Torre X, Fiacco I, Palermo A, Botrè F:
Modulation of phase II metabolism: A case study on 19-norandrosterone
42 - 48 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Giraud S, Saugy M, Robinson N:
Growth Hormone distributions from a cohort of track and field Athletes
49 - 54 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Clarke E, Goebel C:
Identification and Detection of LH in Urine
55 - 62 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Naud J, Julien A, Ayotte C:
Statistical analysis of the hGH recombinant and pituitary ratios obtained from routine testing of athletes samples with the CMZ isoform kits
63 - 67 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Kishikawa Y, Ohtsuki T, Ueki M:
Origin identification of recombinant glycoprotein hormones by monitoring human-type glycans
68 - 74 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

POSTER PRESENTATIONS

Ahi S, Beotra A, Upadhyay A, Bhardwaj A, Jain S:
Excretion study of Clomiphene and its correlation with unusual findings in the routine doping control samples
75 - 78 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Inthong T, Matayatsuk Phechkrajang C, Wilairat P, Chaikum N:
Detection of deacetylmetipranolol arising from storage of standard solution of metipranolol
79 - 83 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Palermo A, Botrè F, de la Torre X, Fiacco I, Mazzarino M:
Metabolic profile of budesonide after different administration routes and doses
84 - 88 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Donati F, Boccia F, Stampella A, de la Torre X, Botrè F:
microRNA analysis for the detection of autologous blood transfusion
89 - 92 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Giraud S, Voss S, Alsayrafi M, Bourdon P, Schumacher Y, Saugy M, Robinson N:
Effect of plasma volume on the marker approach to detect Growth Hormone doping
93 - 97 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Tsivou M, Giannadaki E, Lyris M, Georgakopoulos C:
Stabilization efficiency of spray coated chemical mixture on hCG degradation by proteases
98 - 101 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Walpurgis K, Piper T, Wenzel F, Schänzer W, Thevis M:
Investigations on storage-induced changes of the red blood cell lipidome
102 - 106 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Weber C, Kamber M, Stamm H:
Phthalates Content in Urine Samples of Swiss Athletes during Routine Doping Controls in 2012
107 - 111 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

He C, Zhang L, Jing J, Yang S, Dong Y, Xu Y, Wang X:
Investigation of the ‘not satisfactory’ results in CSCQ performance test
112 - 115 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Mazzarino M, Calvaresi V, de la Torre X, Sebastianelli C, Botrè F:
Development and validation of an LC-MS/MS analytical procedure for the combined detection of prohibited peptides in biological fluids
116 - 120 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Stan C, Toboc A, Stanescu A, Zorio M, Pop V:
Performance evaluation using the “Decision Chart” and ”Six Sigma Metric” concept for measurement of haematological parameters for Athlete Biological Passport
121 - 125 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Kishikawa Y, Ohtsuki T, Ueki M:
Real-time tracking of hematological parameters by robust mobile testing unit
126 - 128 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Reihlen P, Blobel M, Völker-Schänzer E, Majer B, Schänzer W:
Detection windows of rEPO using SAR- and IEF-PAGE
129 - 132 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

de la Torre X, Colamonici C, Curcio D, Jardines D, Beotra A, Jain S, Kaur T, Shrivastava A, Botrè F:
Nandrolone criteria for 19-norandrosterone Isotope Ratio Mass Spectrometric confirmation
133 - 136 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Edey C, Brooker L, Kazlauskas R, Goebel C:
Axiron – a transdermal testosterone administration case study – steroid profiling & GC/C/IRMS
 137 - 140 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Jain S, Nimker V, Shrivastava A, Jamal H, Lal R, Kaur T, Beotra A, Shukla S:
Effect of microbial degradation on steroid profile and IRMS analysis: A case study
141 - 145 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Mareck U, Gougoulidis V, Flenker U, Schänzer W:
Case study: GC/C/IRMS data of an unsusual urine sample
146 - 149 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Piper T, Thomas A, Schänzer W, Thevis M:
Nitrogen isotope ratios of endogenous urinary AICAR
150 - 153 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Ambrosio G, Botrè F, de la Torre X, Mazzarino M:
In vitro investigation on the effect of antifungals, benzodiazepines and non-steroidal anti-inflammatory drugs on the metabolic profile of morphine
154 - 157 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Balmukanov K, Balmukanov A, Talbayev T:
A rapid method for the analysis of doping substances that are excreted mainly in nonconjugated form in urine.
158 - 161 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Dong Y, Yan K, Ma Y, Wang S, He G, Deng J, Yang Z:
Dilute and shoot approach for the screening of stimulants LC-dynamic MS/MS
162 - 167 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Harju L, Uusalo R, Kuuranne T, Leinonen A:
LC-MS/MS method development of an initial testing procedure for prohibited substances in sport
168 - 171 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Charlebois A, Ayotte C:
Following steroid profiles outside the WADA management system (ADAMS)
172 - 176 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Cuervo D, Lu J, Fernández-Álvarez M, Muñoz-Guerra J, Xu Y, Aguilera R:
Searching for alternative danazol metabolites via Accurate-Mass by using Liquid Chromatography Quadrupole Time-of-Flight (LC-QTOF/MS)
177 - 181 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Fernández-Álvarez M, Lu J, Cuervo D, Xu Y, Muñoz-Guerra J, Aguilera R:
Detection of new Oral-Turinabol metabolites by LC-QToF
182 - 187 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Fragkaki A, Angelis Y, Kiousi P, Georgakopoulos C, Lyris E:
Detection of sulpho-conjugated urinary metabolites of methenolone by liquid chromatography/high resolution mass spectrometry
188 - 192 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Mareck U, Fußhöller G, Haenelt N, Geyer H, Guddat S, Gougoulidis V, Klose C, Thevis M, Schänzer W:
Quality control in steroid profiling
193 - 195 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Mareck U, Geyer H, Fußhöller G, Haenelt N, Guddat S, Gougoulidis V, Klose C, Thevis M, Schänzer W:
German athletes with naturally elevated T/E – evaluation of follow up studies
196 - 198 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Soldevilla Navarro A, Vargas García-Tenorio S, Fernandez Alvarez M, Muñoz-Guerra J, Aguilera R:
An automated derivatization method for anabolic steroids prior to GC-MS/MS analysis
199 - 202 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Angelis Y, Petropoulou G, Athanasiadou I, Fragkaki A, Archontaki E, Lyris E:
Detection of synthetic anabolic androgenic steroids and metabolites by LC-Q-TOFMS after derivatization with 1,1’-carbonyldiimidazole
203 - 207 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Donati F, Nardini P, Stampella A, de la Torre X, Botrè F, Mazzarino M, Palermo A:
Stability of urine samples for samples identification: DNA-based typing Vs. steroid profile
208 - 210 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Ahi S, Beotra A, Dubey S, Kaur T, Upadhyay A, Priyadarshi R, Shrivastava A, Jain S:
Scientific developments and challenges in testing on LC-MS/MS in NDTL, India (2009-2013)
211 - 214 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

Pop V, Zorio M, Vajiala G, Lamor M, Bican G, Pop A, Alexandrescu V, Toboc A, Stanescu A:
Antidoping testing at the European Youth Olympic Winter Festival (EYOWF/FOTE), 17-23 February 2013, Poiana Brasov, Bucharest, Romania
215 - 218 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (22). Sport und Buch Strauß - Köln 2014 

PRESENTATIONS ABSTRACTS – LECTURES

Sobolevsky T, Krotov G, Rodchenkov G:
Antidoping analyses at the Sochi Olympic and Paralympic Games 2014
219

Görgens C, Guddat S, Schänzer W, Thevis M:
High-throughput screening and confirmation of myo-inositol trispyro-phosphate (ITPP) in human urine by HILIC high resolution / high accuracy mass spectrometry for doping control purposes
220

Kuuranne T, Kobayashi M, Pelander A, Ketola R, Leinonen A: Targeting misuse of designer drugs: An axample on method development for the detection of 2-amino-N-ethyl-1-phenyl-butane in urine samples
221

Matabosch X, Monfort N, Pozo O, Ferrés M, Pérez-Mañá C, Farré M, Segura J, Ventura R:
Urinary profiles of betamethasone metabolites after different administration routes
222

Thieme D, Anielski P, Geyer H, Gfrerer L, Krumbholz A:
Is hair analysis of clenbuterol suitable to discriminate therapeutic use from contamination?
223

Tretzel L, Thomas A, Geyer H, Gmeiner G, Forsdahl G, Pop V, Schänzer W, Thevis M:
Use of dried blood spots in doping control analysis of anabolic steroid esters
224

Walpurgis K, Krug O, Thomas A, Laußmann T, Schänzer W, Thevis M:
Detection of an unknown fusion protein in confiscated black market products
225

Geldof L, Lootens L, Van Lysebeth J, Meuleman P, Leroux-Roels G, Deventer K, Van Eenoo P:
Metabolic study of a steroid product containing dimethazine using human liver microsomes and a chimeric mouse model
226

Thomas A, Schänzer W, Thevis M:
Determination of human insulin and its analogues in human plasma using liquid chromatography coupled to ion mobility mass spectrometry (LC-IM-MS)
227

Krotov G, Semenistaya E, Zvereva I, Thomas A, Rodchenkov G, Thevis M:
Studies on the metabolism of GHRP-2 and GHRP-6 after nasal administration
228

Bowers L, Fedoruk M, Eichner D, Madsen M:
On the Interpretation of Urinary Steroid Profiles: Effect of ethyl glucuronide and normalization factors
229

Baume N, Jan N, Vouillamoz M, Gridale R, Earl M, Robinson N, Saugy M:
Evaluation of longitudinal steroid profiles from football players in UEFA competitions between 2008 and 2012
230

Nair V, Campbell T, Eichner D:
Evolution of the supplement industry: a case study with MENT
231

Tudela E, Deventer K, Geldof L, Van Eenoo P:
Detection of conjugated and unconjugated anabolic steroids in urine by dilute-and-shoot liquid chromatography-high resolution mass spectrometry
232

Pozo O, Fabregat A, Marcos J, Ventura R, Segura J:
Semi-untargeted metabolomic approach based on precursor ion scan for matbolic studies of anabolic steroids
233

Deventer K, Roels K, Van Eenoo P:
Improved sample throughput in LC-MS analysis: Combining dilute-and-shoot and extraction strategies
234

de la Torre X, Colamonici C, Parr MK, Curcio D, Botrè F:
Exogenous formestane confirmation by mass spectrometric techniques
235

Polet M, Van Renterghem P, Van Gansbeke W, Van Eenoo P:
Studies on the minor metabolite 6a-hydroxy-androstenedione for doping control purposes and its contribution to the steroid
236

Piper T, Thomas A, Baume N, Sobolevsky T, Saugy M, Rodchenkov G, Schänzer W, Thevis M:
Determination of 13C/12C Ratios of Endogenous Urinary AICAR
237

Flenker U, Riemann P, Macha A, Gougoulidis V, Haenelt N, Hülsemann F, Parr MK, Schänzer W:
Metabolic isotope fractionation - fundamentals and examples from steroid
238

Riemann P, Macha A, Gougoulidis V, Flenker U, Parr MK, Schänzer W:
13C/12C ratios of endogenous urinary steroids after oral administration of androsta-1,4,6-triene-3,17-dione
239

Wang J, Yang R, Yang W, Liu X, Xing Y, Xu Y:
Detection of testosterone manipulated with 13C labeled standards
240

Riemann P, Fußhöller G, Haenelt N, Müller D, Macha A, Gougoulidis V, Flenker U, Parr MK:
13C/12C ratios of 5α-androst-1-ene-3,17-dione in human urine
241 - 242

Leuenberger N, Ansermet C, Schumacher Y, Saugy M:
A Fast Automated Screening Method for the Detection of Autologous Blood Transfusion in Sports
243

Cowan D, Bartlett C, Böhning D, Böhning W, Guha N, Holt RIG, Sönksen PH, Wojek N, Becker JO, Bowers LD, Butch AW, Cox HD, Hoofnagle AN, Lopes F, Parkin MC,Thevis M, Thomas A, Woldemariam GA:
IGF-1 and P-III-NP biomarkers of human growth hormone administration – three additional methods for measurement and determination of the biomarker score
244

Butch A, Getachew WA:
Development of an immunoextraction technique for quantitation of urinary hCG, hCG free beta and hCG beta core fragment by LC-MS/MS
245

Smeal S, Miller G, Eichner D:
Changes in Osmolality and Albumin within the Blood Profile following Exercise-Induced Dehydration
246

Okano M, Sato M, Lal R, Jain S, Kageyama S:
Doping control analysis of darbepoetin alfa and its biosimilar Cresp by UPLC-MS/MS
247

Reichel C:
Modulating SAR-PAGE for peginesatide and global peptidic ESA detection
248 - 249

Reihlen P, Blobel M, Kempkes R, Völker-Schänzer E, Majer B, Schänzer W:
Optimizing SAR-PAGE analysis 250
Dehnes Y, Ström H, Myrvold L, Drevin M, Böwer N, Ericsson M, Hemmersbach P:
MAIIA EPO SeLect – a screening kit for the detection of recombinant EPO analogues
251

Vogel M, Blobel M, Thomas A, Walpurgis K, Schänzer W, Reichel C, Thevis M:
Receptor Affinity Pre-Purification of Erythropoietin Derivatives for Sports
252

PRESENTATIONS ABSTRACTS - POSTERS PAGE

Dong Y, Yan K, Ma Y, Shen L, Wang X, Xu Y:
Excretion study of Clomiphene and its correlation with unusual findings in the routine doping control samples
253

Ericsson M, Thörngren J:
A fast and simple quantitative analysis for glycerol in urine using liquid chromatography with high resolution orbitrap mass specroscopy
254

Okano M, Nishitani Y, Sato M, Kageyama S:
Glycerol cases due to self-catheterization
255

Guddat S, Görgens C, Thevis M, Schänzer W:
Detection of glycerol by hydrophilic interaction chromatography high resolution/high accuracy mass spectrometry
256

Esposito S, Deventer K, Van Eenoo P:
Identification of Pro-Pro-hGHRH(1-44), a novel hGHRH analogue with doping potential, in a confiscated product
257

Perrenoud L, Baume N:
Dobutamine metabolism study by UHPLC-HR-MS/MS
258

Kwiatkowska D, Jarek A, Wójtowicz M, Pasik M, Goebel C, Pokrywka A, Kazlauskas R:
N,N-dimethyl-2-phenylpropan-1-amine – a new doping agent
259

Wójtowicz M, Jarek A, Goebel C, Turek-Lepa E, Pokrywka A, Stanczyk D, Kazlauskas R, Kwiatkowska D:
2-Amino-N-ethyl-1-phenylbutane (EAPB) detection method - validation and application
260

Grainger J, Goebel C, Handelsman D, Idan A, Turner L, Conway A:
Detection of gonadotropin releasing hormone analogs and metabolites
261

Ismail M, Lee S, Chan S:
The evaluation of glycoproteomic methodology for differential analysis of recombinant and endogenous erythropoietin
262

Krotov G, Nikitina M, Rodchenkov G:
Possible origins of lack of positive samples on homologous blood transfusion
263

Forsdahl G, Geisendorfer T, Erceg D, Norvic N, Nguyen M, Gmeiner G:
Screening for endogenous hormones in serum samples: Effect of testosterone applications
264

Kojima A, Okano M, Sato M, Nishitani Y, Dohi M, Kageyama S:
Advantage of blood analysis for in-competition testing; Excretion studies of ephedrine and methylephedrine
265

Hülsemann F, Piper T, Lehn C, Schneiders S, Schänzer W:
Global spatial distribution of natural stable carbon isotope ratios in modern humans
266

Hullstein I, Sagredo C, Hemmersbach P:
Carbon isotope ratio determination of seized nandrolone, boldenone and testosterone preparations in Norway
267

Wang J, Yang R, Yang W, Liu X, Xing Y:
Influences of progesterone administration on IRMS test of doping control
268

Monfort N, Martínez L, Bergés R, Segura J, Ventura R:
Fast screening method for stimulants in urine by UPLC-MS/MS. Identification of isomeric compounds
269

Ericsson M, Jacobsson Schulze J, Mullen J, Berglund Lindgren E, Ekström L, Lindén Hirschberg A:
The impact of genetics and hormonal contraceptives on the steroid profile in female athletes
270

Guddat S, Fußhöller G, Geyer H, Thevis M, Schänzer W:
Ultra sensitive detection of stanozolol – positive experiences
271

Kiousi P, Angelis Y, Fragkaki A, Lyris E, Georgakopoulos C:
Studies on excretion of mesterolone sulfo-conjugate metabolites extracted by ethylacetate
272

Schweizer Grundisch C:
Degradation of Methyltestosterone in urine samples
273

Lee J, Kim S, Cha E, Lee K, Kim H, Son J, Park J, Kwon O:
Development and validation of liquid chromatography-silver ion coordination ionspray tandem mass spectrometric method for the simultaneously analysis of steroids in human urine
274

Coetzee A, Van der Merwe P:
Prevalence of the use of selective cyclo-oxygenase 1 and 2 inhibitor drugs in urine of athletes
275

Krug O, Thomas A, Walpurgis K, Piper T, Sigmund G, Lagojda A, Schänzer W, Thevis M:
Mass spectrometric analysis of black market products by HPLC-(HR)MS, GC-(HR)MS and 1D-gel electrophoresis-UPLC-MSn
276

Krug O, Kutscher D, Thevis M:
Mass spectrometric analysis of urinary cobalt by HPLC-(HR)MS and ICP-MS for determination of cobalt concentrations in top athletes
277

Jarek A, Wójtowicz M, Turek-Lepa E, Chajewska K, Pokrywka A, Szczepanska Z, Kwiatkowska D:
Permanent use of trimetazidine by athletes in Poland from 2008 to 2013
278

Reinartz A, Guddat S, Sigmund G, Schänzer W, Thevis M:
Doping control analysis of trimetazidine – GC-MS/NPD and LC-MS/MS approaches and retrospective data evaluation from 1999 – 2013
279

Camacho E, Mercado K, Mendez E, Rodriguez JL, Herrera JM, Velasco B:
Influence of AOD-9604 on the WADA hGH isoform immunoassay
280

 __________________________________________________________________

Manfred Donike Workshop - Proceedings of the 31st Cologne Workshop on Dope Analysis 2013
In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013  

TABLE OF CONTENTS

LECTURES

Marclay F, Mangin P, Margot P, Saugy M:
Perspectives for Forensic Intelligence in Anti-Doping: Thinking outside of the box.
11 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Sardela V, Sardela P, Deventer K, Araújo A, Cavalcante K, Padilha M, Pereira H,
Van Eenoo P, de Aquino Neto F:
Identification and confirmation of sympathomimetic alkylamines in urine using
liquid chromatography-mass spectrometry and gas chromatography-mass
spectrometry
12  In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Ahi S, Dubey S, Beotra A, Kaur T, Jain S:
A comprehensive and sensitive screening of doping agents on UPLC-MS/MS: An
approach towards fulfillment of WADA TD2013 MRPL
13 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Musenga A, Cowan D:
Fast screening by UHPLC-HRMS in high throughput doping control
14 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Höppner S, Schänzer W, Thevis M:
SIRT1 activators: Metabolism studies and detection in human plasma and urine
15 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Guha N, Erotokritou-Mulligan I, Nevitt SP, Francis M, Bartlett C, Cowan DA, Bassett EE,
Sonksen PH, Holt RIG:
Biochemical markers of insulin-like growth factor-I (IGF1) misuse in athletes
16 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

De Brabanter N, Esposito S, Geldof L, Lootens L, Deventer K, Van Eenoo P:
Phase I and phase II metabolism of synthetic cannabinoids, the Ghent strategy.
17 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Parr MK, Opfermann G, Rudolf T, Pokrywka A, Kwiatkowska D, Schänzer W:
Differentiation between the administration of the aromatase inhibitor androstatrienedione
and the anabolic androgenic steroid boldenone
18 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Jain S, Shrivastava A, Kaur T, Soni A, Haseen J, Nimker V, Beotra A:
Detection of the misuse of testosterone gel in subjects with low basal
Testosterone/Epitestosterone (T/E) value
19-25 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Parr MK, Blokland MH, Liebetrau F, Schmidt AH, Schänzer W, Sterk S:
Enantiomeric separation of clenbuterol as analytical strategy to distinguish abuse
from meat contamination
26 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Tudela E, Deventer K, Geldof L, Van Eenoo P:
Detection and identification of glucuronidated stanozolol metabolites by liquid
chromatography-tandem mass spectrometry
27-32 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Guddat S, Fußhöller G, Thomas A, Geyer H, Opfermann G, Thevis M, Schänzer W:
Stanozolol – new aspects of metabolism, sample preparation and analytical
methodology
33 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Mazzarino M, de la Torre X, Fiacco I, Khevenhüller F, Botrè F:
Effects of ketoconazole on the excretion kinetics of methandienone. An in vivo
study
34-40 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Geldof L, Lootens L, Deventer K, Polet M, Eichner D, Botrè F, Meuleman P, Leroux-Roels G,
Van Eenoo P:
In vitro and in vivo metabolism studies of a nutritional supplement containing
methylstenbolone
41 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Lootens L, Geldof L, Tudela E, Meuleman P, Leroux-Roels G, Botrè F, Deventer K,
Van Eenoo P:
Metabolic study of oxabolone using human liver microsomes and humanized mice
42-47 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Van Renterghem P, Deventer K, Van Eenoo P:
Influences on the alternative steroid profile, part I
48-53 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Esposito S, Deventer K, Goeman J, Van der Eycken J, Van Eenoo P:
TB-500: from horseracing to human doping
54 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Thevis M, Piper T, Horning S, Juchelka D, Schänzer W:
Hydrogen Isotope Ratio Mass Spectrometry and High Resolution/High Accuracy Mass
Spectrometry in Metabolite Identification Studies: Detecting Target Compounds for
Sports Drug Testing
55 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Ahrens B, Butch A:
A simplified and accurate method for the analysis of urinary metabolites of
testosterone-related steroids using chromatography-combuston-isotope ratio mass
spectrometry
56-61 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Polet M, Van Gansbeke W, Van Renterghem P, Van Eenoo P:
Profiling of urinary formestane and confirmation by isotope ratio mass
spectrometry
62 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Riemann P, Müller D, Gougoulidis V, Flenker U, Parr M, Schänzer W:
13C/12C ratios of endogenous steroids after oral boldenone administration
63 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Brooker L, Hasick N, Williams M, Goebel C:
Stable Carbon Isotope Ratio Profiling of Nandrolone and Boldenone Ester
Preparations
64 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Piper T, Degenhardt K, Federherr E, Thomas A, Saugy M, Thevis M:
Effect of changes in the deuterium content of drinking water on the hydrogen
isotope ratio of urinary steroids in the context of sports drug testing
65 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Flenker U, Riemann P, Gougoulidis V, Haenelt N, Köhler K, Braun H, Engelmeyer E,
Predel HG, Mester J:
13C/12C Ratios of Endogenous Urinary Steroids from a Population of Young Elite
Athletes
66 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Thieme D, Rautenberg C, Grosse J, Schoenfelder M:
Detection of salivary steroid levels after transdermal testosterone administration
67 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Walpurgis K, Slijepcevic M, Wenzel F, Thomas A, Geyer H, Franz S, Schänzer W, Thevis M:
Influence of repeated subcutaneous G-CSF injections on selected blood parameters
relevant for monitoring programs in sports drug testing
68 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Thomas A, Walpurgis K, Delahaut P, Kohler M, Schänzer W, Thevis M:
Analysis of small interfering (si)-RNA by means of LC-HRMS/MS for doping controls
69 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Reichel C:
Sialic acid O-acetylation as characteristic marker for recombinant erythropoietins
70 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Jain S, Lal R, Raj A, Tyagi D, Beotra A, Kaur T:
Characteristics of IEF Patterns and SDS-PAGE Results of Indian Darbepoeitin
(CRESP) and its detection window following single subcutaneous injections
71-77 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Okano M, Sato M, Kageyama S:
Identification of darbepoetin alfa in human urine by LC-MS/MS
78 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Deventer K, Esposito S, Jimenez A, Roels K, Van Eenoo P:
Detection of hydroxyethylstarch and dextran by UHPLC-orbitrap high resolution
mass spectrometry
79 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Clarke E, Agon V, Goebel C:
Analysis of Carbohydrate Moieties of Recombinant and Natural Peptide Hormones
by LC-MSMS
80-86 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Reihlen P, Blobel M, Völker-Schänzer E, Majer B, Kempkes R, Schänzer W:
Identification of mixed profiles in EPO routine analysis
87-89 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

POSTER PRESENTATIONS

PAhi S, Beotra A, Upadhyay A, Jain N, Priyadarshi R, Jain S:
Urinary excretion profile of inhaled formoterol and budesonide in humans:
correlation with revised threshold and permitted dose of formoterol
90-93 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Cholbinski P, Wicka M, Turek-Lepa E, Pokrywka A, Kwiatkowska D:
Clomiphene – How about including the parent compound in screening procedures?
94-97 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Garrostas L, Marcos J, Segura J, Ventura R:
Screening method for selected doping substances by gas chromatography – triple
quadrupole mass spectrometry: Reaching minimum required performance limits
98-102 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Kaliszewski P, Cholbinski P, Konczak D, Wicka M, Michalak D, Pokrywka A, Kwiatkowska D:
Is budesonide administration by inhalation really permitted?
103-107 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Kelly B, Madsen M, Sharpe K, Nair V, Eichner D:
A Population Study of Urine Glycerol Concentrations in Elite Athletes Residing in
North America
108 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Mareck U, Guddat S, Geyer H, Thevis M, Schänzer W:
Urinary ethyl glucuronide in samples with elevated T/E ratios – evaluation of
gender, sport discipline, type of control and concentration
109-112 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Palonek E, Andersson A, Ericsson M:
Analysis of Synthetic Cannabinoids in Urine by UPLC-MSMS and K2 (Synthetic
Cannabinoids-1) Urine Enzyme Immunoassay
113-116 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Saardpun N, Panan S, Wilairat P, Chaikum N:
Investigation of possible interference of the metabolite of etoricoxib (Arcoxia®)in
the detection of 16-hydroxyprednisolone by LC-MS/MS
117-120 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Sobolevsky T, Dikunets M, Rodchenkov G:
In vitro and in vivo metabolism of RAD140, a novel non-steroidal SARM
121-124 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Sobolevsky T, Prasolov I, Rodchenkov G:
Newcomers to the synthetic cannabinoid family: adamantyl substituted indole
carboxamides APICA and its fluorinated analog
125 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Tikum N, Kaewklum S, Wilairat P, Chaikum N:
Detection of Glycerol in Human Urine Using the Screening Procedure for
Hydroxyethyl Starch and Dextran
126-129 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Cuervo D, Muñoz-Guerra JA:
Fully Automatized Sample Preparation for Detection of 69 Doping-Related
Substances
130-135 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Grainger J, Trout G, Goebel C:
Evaluation of ionic liquid GC columns
136-139 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Chundela Z, Große J:
Metabolites of methylnortestosterone
140-143 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

de la Torre X, Colamonici C, Curcio D, Mazzarino M, Molaioni F, Botrè F:
In-situ steroids 19-demethylation vs aromatization
144-146 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Forsdahl G, Vatne H, Geisendorfer T, Gmeiner G:
Screening of Testosterone Esters in Human Plasma
147 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Kageyama S, Hirai C, Okano M, Asakawa S, Ikekita A, Akama T, Suzuki H:
Strategy for detecting testosterone doping in Japan – The 1st year
148-151 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Strahm E, Sjöberg U, Garle M, Rane A, Ekström L:
Implication of human UGT2B7, 2B15 and 2B17 in 19-norandrosterone metabolism
152 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Tudela E, Deventer K, Van Eenoo P:
Stability study of 3’-hydroxystanozolol glucuronide
153-155 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Balcells G, Bartlett C, Cowan D:
Experience of using MAIIA columns for EPO testing at the 2012 Olympic and
Paralympic Games
156-159 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Donati F, Acciarini R, Colicchia S, Corpetti G, de la Torre X, Ianella L, Stampella A, Botrè F:
Searching for markers to detect autologous blood transfusion. An investigation on
platelets activation by flow cytofluorimetry
160 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Donati F, Colicchia S, de la Torre X, Iannella L, Botrè F:
Fast screening for liposomes encapsulated hemoglobin (LEH) using ADVIA 120 flow
cytomery-based hematological analyzer
161-163 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

He C, Jing J, Zhang L, Zhou X, Yang S, Xu Y, Hu M, Wu M:
Certain Unknown Effects on the GH Isoform Ratios
164-167 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Kniess A, Ziegler E, Thieme D, Müller R:
Intra-Individual Variation of GH-dependent Markers in Athletes: Comparison of
Population Based and Individual Thresholds for Detection of GH Abuse in Sports
168 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Krug O, Thomas A, Walpurgis K, Piper T, Sigmund G, Geyer H, Schänzer W, Thevis M:
Mass spectrometric analysis of black market products by HPLC-(HR)MS,GC-(HR)MS
and 1D-gel elektrophoresis-UPLC-MSn
169-172 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Santos Levy R, Davies de Oliveira Sardela P, Figueiredo Sardela V, Pereira HMG, Radler de
Aquino Neto F:
Urinary reference intervals of gonadotrophic hormones in Brazilian athletes using
the IMMULITE immunoassay system
173-176 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Monfort N, Ventura R, Valvi D, Balcells G, Vrijheid M, Segura J:
Phthalates in urine as markers of blood transfusion in sports: Population
concentrations of five DEHP metabolites and reference limits
177-181 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Sobolevsky T, Prasolov I, Rodchenkov G:
Urinary metabolism of ibutamoren, a small molecule growth hormone secretagogue
182-186 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Turi S, Corpetti G, de la Torre X, Garribba F, Botrè F:
Technical improvement for the detection of erythropoietins in biological matrices:
An update
187-190 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Zhang L, Xu Y, He C, Jing J, Yang Z, Deng J:
Detection window of CERA abuse through haematology profiles post single injection
191-195 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Brailsford A, Gavrilović A, Kicman A, Cowan D:
Isotope ratio mass spectrometry at the London 2012 Olympic and Paralympic Games
- Experience and Conclusions
196-200 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Piper T, Thevis M, Saugy M:
Measured deviations from its certified values in carbon isotope ratios of the
secondary isotopic reference material USADA 33-1 as a function of signal intensity
201 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Fiacco I, Calabrese F, de la Torre X, Mazzarino M, Botrè F:
Degradation kinetics of selected threshold compounds in biological samples: effect
of different external conditions
202-206 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Grobbelaar E, Van der Merwe P, Venter P, Human B:
Coca Tea: Just an ordinary tea or inadvertent doping?
207-209 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Huynh T, Grainger J, Trout G, Goebel C:
Multi-residue extraction and analysis method for prohibited substances in animal
urine
210-213 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Kuuranne T, Kobayashi M, Leinonen A:
Development of in vitro methodology in metabolite production and analytical
techniques: beta-blockers and TOF-MS screening of unknown metabolites
214-217 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013 

Pop V, Bican G, Pop A, Lamor M, Zorio M:
New prohibited substances addition to procedures using triple quadrupole LC/MS2
technique
218-222 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Sardela V, Pereira H, Radler de Aquino Neto F:
Prevalence of stimulants as doping agents in Brazil
223 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Thörngren JO, Ericsson M, Masquelier M:
Screening and confirmation results of three interesting cases in 2012 at the Doping
Control Laboratory, Karolinska University Hospital
224-228 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Torres Castellanos M, Estevez I, Gonzalez S, Martinez D, Montes de Oca R, Granda M:
Prevalence of Caffeine use in urine samples analyzed during 2010 2012
229-231 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Wang J, Liu X, Xing Y, Xu Y, Wang X, He Z:
Influences of musk administration on the profiles and the carbon isotope ratios of
urinary steroids
232 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Kwan SH, Ismail MN, Bahrudin F:
Comparison of purification techniques for erythropoietin anti-doping analysis
233-236 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Martínez Brito D, Velasco Bejarano B, Correa Vidal MT, Camacho Frias E:
Steroid profile.Differences inside de Latin-American population of athletes
237-240 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Thomas A, Walpurgis K, Krug O, Schänzer W, Thevis M:
Screening for small peptides in urine by means of nano-UPLC-MS/MS in doping
controls
241 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Tsivou M, Giannadaki E, Georgakopoulos D, Lyris E, Georgakopoulos C:
Stabilization in urine collection containers: reality or science-fiction
242-246 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Greer C, Grainer J, Trout G, Fu S, Goebel C:
Matrix Effects and Internal Standards for Prednisolone and Prednisone
247-249 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Martin L, Schatz P, Mortensen B, Martin JA, Lasne F:
Detection of peginesatide by SDS-PAGE
250-252 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Reihlen P, Kempkes R, Blobel M, Völker-Schänzer E, Majer B, Schänzer W, Thevis M:
Recovery of supposedly degrated CERA from urine samples
253-256 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

Orlovius AK, Thomas A, Schänzer W, Thevis M:
Influence of AOD-9604 on the WADA hGH isoform immunoassay
257 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (21). Sport und Buch Strauß - Köln 2013

________________________________________________________________

Manfred Donike Workshop - Proceedings of the 30th Cologne Workshop on Dope Analysis 2012
In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012 

TABLE OF CONTENTS

LECTURES

Sardela VF, Deventer K, Pereira HMG, Aquino Neto FR, Van Eenoo P:
Development and validation of a UHPLC-tandem mass spectrometric method for the direct detection of formoterol in human urine
10   In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Orlovius AK, Guddat S, Parr MK, Guetschow M, Thevis M, Schänzer W:
In vitro formation of fenoterol sulfates using different tissue preparations and recombinant sulfotransferases
11 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Muñoz G, Tudela E, Muñoz-Guerra JA:
Matrix effects marker for multianalyte analysis of glucocorticoids and diuretics by LC-MS/MS in biological samples
12 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Mazzarino M, Fiacco I, Palermo A, de la Torre X, Botrè F:
The use of cytochrome P450 inhibitors in sport. A new generation of doping masking agents?
13-22 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Jan N, Marclay F, Schmutz N, Smith M, Lacoste A, Saugy M:
Use of Forensic Investigations in Anti-Doping
23-27 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Parr MK, Daniels J, Schlörer NE, Schänzer W:
Structure proof of tibolone 3-hydroxy metabolite
28-33 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Sobolesvsky T, Rodchenkov G:
Long-term detection of dehydrochloromethyltestosterone: one-year experience
34-37 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Okano M, Ueda T, Kano H, Nichitani Y, Ikekita A, Sato M, Kageyama S:
UDP-glucuronosyltransferase 2B17 genotyping in Japanese athletes and evaluation of the current sports drug testing for detecting testosterone misuse by female athletes
38 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Sobolesvsky T, Rodchenkov G:
Oxymetholone and desoxymethyltestosterone: how many metabolites do we know? HPLC clean-up to identify the new targets
39 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Badoud F, Grata E, Boccard J, Rudaz S, Veuthey JL, Saugy M:
Profiling of endogenous steroids by UHPLC-QTOF-MSE
40-45 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Parr MK, Schänzer W, Schlörer N, Voronina E, Hengevoss J, Diel P:
Alternative detection strategies for anabolic steroid abuse by NMR metabonomics and endocrine feedback loop analyses
46-51 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Van Rentgerhem P, Sottas PE, Saugy M, Van Eenoo P:
Validation of a steroidomic model and its application in doping control
52-57 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Lootens L, Geldof L, Decroix L, Deventer K, Botrè F, Leroux-Roels G, Meuleman P, Van Eenoo P:
Metabolic study of Prostanozol using human liver microsomes and humanized mice
58-64 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Gómez C, Pozo O, Marcos J, Segura J, Ventura R:
Alternative long-term markers for the detection of methyltestosterone misuse
65 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Pereira HMG, Silva ACA, Barbosa SS, Silva RSF, Padilha MC, Aquino Neto FR:
Two-dimensional comprehensive gas chromatography coupled to time of flight mass spectrometry in doping control: Evaluation of the chromatogra-phic plane organization
66-72 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

De Brabanter N, Van Gansbeke W, Geldof L, Van Eenoo P:
Improvements in GC-QqQ-MS screening, 1 year of experience
73 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Deventer K, Jimenez A, Esposito S, Roels K, Van Eenoo P:
Application of UHPLC-orbitrap based mass spectrometry with scan-to-scan polarity switching for the direct detection of doping agents in urine
74 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Polet M, Van Gansbeke W, Deventer K, Van Eenoo P:
Development of a sensitive GC-C-IRMS method for the analysis of androgens
75 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Ouellet A, LeBerre N, Ayotte C:
A simplified and accurate method for the analysis of urinary metabolites of testosterone-related steroids using chromatography-combuston-isotope ratio mass spectrometry
76-81 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Esposito S, Deventer K, Van Eenoo P:
Doping control analysis of desmopressin in human plasma and urine by HPLC-ESI-MS/MS
82-86 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Dehnes Y, Drange M, Ottersen SB, Hemmersbach P:
Longitudinal profiles of indirect markers for GH misuse
87-92 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Möller I, Thomas A, Geyer H, Schänzer W, Thevis M:
Detection and method validation of peginesatide in human serum by means of LC-MS/MS
93-99 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

POSTER PRESENTATIONS  

Machala E, Grainger J, Agon V, Goebel C:
Validation and implementation of MAIIA columns into routine analysis of urinary EPO screening
100-102 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Desharnais P, Naud JF, Ayotte C:
Desialylation improves the detection of recombinant erythropoietins in urine samples analyzed by SDS-PAGE
103-109 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Okano M, Nishitani Y, Sato M, Kageyama S:
Administration study of growth factors
110 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Esposito S, Deventer K, Van Eenoo P:
Characterization and identification of a C-terminal amidated mechano growth factor (MGF) analogue in black market products
111 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Virus E, Dikunets M, Sukhanova I, Sobolevsky T, Rodchenkov G:
High-temperature liquid chromatography/Orbitrap mass spectrometry with hypercarb column for selective screening of exogenous anabolic steroids in human urine
112-115 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Sobolevsky T, Dikunets M, Sukhanova I, Rodchenkov G:
Applicability of routine analytical procedures to detect andarine and ostarine. A comparative study
116-119 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Sobolevsky T, Savelieva N, Semenistaya E, Rodchenkov G:
Importance of phase II metabolites for the detection of beta-blockers by direct urine analysis
120-123 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Bourmbopoulou A, Roumana M, Vassilaki F, Angelis YS, Lyris M, Tsivou M, Kiousi P, Vouroudi A, Koupparis MA, Georgakopoulos G:
A unified doping screening procedure based on LLE with ethyl acetate and combined GCMS, GCHRMS and LCQTOFMS analysis
124-128 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Grainger J, Trout G, Goebel C:
Multi-residue extraction and analysis method for prohibited substances in urine
129-131 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Krug O, Thomas A, Walpurgis K, Sigmund G, Schänzer W, Thevis M:
Analysis of confiscated products with suspiciously doping relevant ingredients by GC-MS, LC-HRMS and LC-MSn
132-134 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

De Brabanter N, Van Gansbeke W, Hooghe F, Van Eenoo P:
Fast quantification of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid (THCA) using microwave-accelerated derivatisation and gas chromatography-triple quadrupole mass spectrometry (GC-QqQ-MS)
135-138 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Mazzarino M, Fiacco I, Turi S, Botrè F:
A simple and rapid procedure for the determination of the urinary concentration of formoterol by LC-MS/MS
139-143 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Ergaliuly G, Balmukanov K, Beksultanova G, Shaldybayeva A, Talbayev T:
Detection and confirmation of hydroxyethylstarch (HES) in human urine by liquid chromatography-mass spectrometry
144-147 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Oueslati F, Slouma R, Halabi N, Safta F, Louselati MH:
Detection of bendroflumethiazide metabolites in human urine using liquid chromatography-tandem mass spectrometry: application to urinary excretion study
148-151 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Okano M, Osada T, Sato M, Uchiyama A, Kageyama S:
Mass spectrometric identification of epitiostanol metabolite: In vitro metabolism using human embryonic stem cell (hESC)-derived hepatocytes and in vivo excretion study in human
152-156 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Sobolevsky T, Dikunets M, Sukhanova I, Virus E, Rodchenkov G:
Detection of PPARδ agonists GW1516 and GW0742 and their metabolites in human urine
157 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Sobolevsky T, Prasolov I, Dikunets M, Rodchenkov G:
In vitro metabolic studies of AM2233 and JWH-210, novel synthetic cannabinoids
158-162 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Sobolevsky T, Prasolov I, Rodchenkov G :
Detection of urinary metabolites of AM-2201 and UR-144, novel synthetic cannabinoids
163 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Fiacco I, de la Torre X, Donati F, Mazzarino M, Botrè F :
Salbutamol metabolism. How to differentiate oral vs. inhaled administrations: looking outside the box.
164-168 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Gómez C, Fabregat A, Pozo O, Marcos J, Deventer K, Segura J, Ventura R :
Exploring boldione metabolism by LC-MS/MS.
169 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Lu J, He G, Wang X, Xu Y, Wu Y, Dong Y, He Z, Liu X, Bo T, Ouyang G:
Detection of new clomiphene metabolites in human urine by liquid chromatography – quadrupole time-of-flight tandem mass spectrometry
170 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Vahermo M, Sutinen H, Leinonen A, Yli-Kauhaluoma J:
Synthesis and characterization of the O-desisopropyl metabolite of bisoprolol
171-174 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Van Renterghem P, Sottas PE, Saugy M, Delbeke F, Brooker L, Polet M, Van Thuyne W, Geyer H, Van Gansbeke W, Schänzer W, Van Eenoo P:
A summary of the Alternative Steroid Profiling WADA project
175-178 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Jardines D, Curcio D, de la Torre X, Colamonici C, Abate MG, Molaioni F, Botrè F:
Longitudinal studies in steroid profiling – a multivariate approach: IRMS extension
179-183 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Jardines D, de la Torre X, Botrè F:
Hydroxylated steroids stability
184-188 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Mareck U, Fußhöller G, Geyer H, Opfermann G, Thevis M, Schänzer W:
GC -single and -triple quadrupole mass spectrometry in steroid profiling
189-192 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Hullstein IR, Svendsen Selmer T, Sagredo C, Henninge J, Juul A, Hemmersbach P:
Urinary steroid profiles after use of testosterone by different routes of administration – how do we detect doping with low doses?
193-196 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Müller D, Opfermann G, Rojas S, Schlörer N, Pokrywka A, Kwiatkowska D, Diel P, Schänzer W, Parr MK:
5α-Androst-1-ene-3,17-dione: metabolism, influence on steroid profile and biological activity
197-200 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Piper T, Emery C, Saugy M:
Norandrosterone analysis by GC/C/IRMS
201-204 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012
 
Brooker L, Drury J, Hasick N, Idan A, Handelsman D, Goebel C:
Co-administration of dietary supplements containing dehydroepi-androsterone and pregnenolone: Investigation of the impact on routine GC-C-IRMS doping control results
205-208 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Piper T, Emery C, Saugy M:
Improved sample preparation and subsequent investigations on population based thresholds for carbon isotope ratios of urinary steroids
209-212 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Pop V, Zorio M, Pop A, Vajiala I:
Population study on Δδ13C values of endogenous steroids in Romania
213-216 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Jain S, Kaur T, Garg T, Srivastava A, Soni A, Beotra A:
Effect of storage condition on C13/C12 ratios and steroid profile
217-220 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Oliver Haupt, Sadrine Tchoukouegno Ngueu, Patrick Diel, Maria-Kristina Parr:
Anabolic effect of ecdysterone results in hyperthrophy of C2C12 myotubes by an estrogen receptor mediated pathway.
221-225 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Covelli C, de la Torre X, Botrè F:
Tramadol detection in sports
226-229 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Coetzee A, Holtzhauzen LJ, van der Merwe P:
Prevalence of the use of analgesics and non-steroidal anti-inflammatory drugs in urine of South African athletes
230-232 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Beotra A, Ahi S, Jain S :
Monitoring of glucocorticosteroids in out-of-competition testing to study the potential pattern of misuse
233-236 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Ahi S, Beotra A, Upadhyay A, Jain N, Singh R, Jain S:
Excretion profile of inhaled formoterol: distinguishing between therapeutic use and abuse in sports
237-240 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Kaur T, Dubey S, Singh SP, Jain S, Agrawal J, Chakraborty M, Beotra A:
Monitoring of nicotine use in sport
241-245 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Reinartz A, Sigmund G, Machnik M, Thevis M, Schänzer W:
Prevalence of antidepressants and biosimilars in elite sport – a follow-up study
246-249 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Koehler K, Braun H, Thevis M, Schänzer W:
Glycerol as prohibited substance: meta-analysis on the effects of glycerol administration on haematocrit and plasma volume
250 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Donati F, Placidi P, Abagnale M, de la Torre X, Botrè F:
Flow cytometry on the move. Extending feasibility of the Cytomics FC500: from homologous blood transfusion detection to soluble molecules multiassay
251-254 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Krumbholz A, Anielski P, Reisch N, Thieme D:
Hair analyses of steroids as tool of disease controle in patients with congenital adrenal hyperplasia
255-258 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012

Jain S, Lal R, Raj A,Tyagi D,Beotra A,Kaur T:
Characteristics of IEF Patterns and SDS-PAGE Results of Indian EPO Biosimilars
259-262 In: Schänzer W, Thevis M,  Geyer H, Mareck U (eds.) Recent Advances In Doping Analysis (20). Sport und Buch Strauß - Köln 2012 

__________________________________________________________________

Manfred Donike Workshop - Proceedings of the 29th Cologne Workshop on Dope Analysis 2011
In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011

TABLE OF CONTENTS

LECTURES

Kazlauskas R, Hasick N:
ASDTL supplements project 2010
10-14  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011  

Parr MK, Opfermann G, Schlörer N, Geyer H, Rataj F, Zierau O, Diel P, Schänzer W:
Sense or nonsense of prohormone designing: Reduced metandienone as supplement
15-23 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Botrè F, Esposito E, de la Torre X:
How we risk: liposomes and steroids
24-33 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011  

Orlovius AK, Guddat S, Parr MK, Koch A, Gütschow M, Thevis M, Schänzer W:
Identification and monitoring of octopamine sulfoconjugate in urine by LC/(ESI)-MS/MS
34-42 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Beotra A, Jain S, Kaur T, Lal R, Ahi S, Dubey S, Garg T, Kashif M, Haseen J, Singh A:
Doping control analysis during the 1st Singapore Youth Olympic Games at National Dope Testing Laboratory, India
43-47 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011  

Hintikka L, Haapala M, Franssila S, Kuuranne T, Leinonen A, Kostiainen R:
Feasibility of gas chromatography-microchip atmospheric pressure photoionization-mass spectrometry in analysis of anabolic steroids
48 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011  

Sobolevsky TG, Rodchenkov GM:
Mass spectral characterization of novel dehydrochloromethyltestosterone and oxandrolone metabolites after HPLC clean-up
49 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Lootens L, De Spaey A, Deventer K, Meuleman P, Leroux-Roels G, Van Eenoo P:
Mibolerone Metabolism in the uPA+/+-SCID chimeric mice
50-59 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011  

Parr MK, Zöllner A, Fußhöller G, Opfermann G, Hobler A, Bernhardt R, Bureik M, Schänzer 
New players in the nightwatch research
60-62 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Van Renterghem P, Sottas P-E, Saugy M, Delbeke FT, Van Eenoo P:
Statistical discrimination of steroid profiles – introduction of steroidomics in doping analysis
63-72 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Kolmonen M, Leinonen A, Kuuranne T, Pelander A, Deventer K, Ojanperä
Application of size exclusion chromatography and time-of-flight mass spectrometry to screening of polysaccharide-based plasma expanders
73-74 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Deventer K, Esposito S, De Boer D,Pozo O, Tsjoen G, Delbeke FT, Van Eenoo P:
Is a simple detection approach possible for desmopressin?
75-83 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011  

Brailsford AD, Gavrilović I, Cowan DA, Kicman AT:
GC+GC with heart-cutting as a simple and rapid sample purification method for GC-C-IRMS
84-93  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Ahrens BD, Butch AW:
Steroid profiles and isotope-ratio mass spectrometry analysis of various metabolites and endogenous reference compounds. The UCLA experience.
94-99  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Piper T, Fußhöller G, Emery C, Schänzer W, Saugy M:
Investigations on carbon isotope ratios and concentrations of urinary formestane
100  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

de la Torre X, Colamonici C, Curcio D, Molaioni F, Pizzardi M, Castrignanò E, Botrè F:
19-norandrosterone origin: A simple procedure for GC/C/IRMS sample preparation by HPLC
101-111  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Piper T, Schlug C, Mareck U, Schänzer W:
Investigations on changes in 13C/12C ratios of endogenous urinary steroids after pregnenolone administration
112 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Agon VV, Goebel C:
Analysis of derivatised carbohydrates of natural and recombinant peptide hormones by LC/MS/M
113-122  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Sato M, Okano M, Kaneko E, Ikekita A, KageyamaS:
Detection of Epoetin-alfa and its biosimilar Epoetin-kappa
123  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Jain S, Beotra A, Kaur T, Lal R, Dubey S, Ahi S, Garg T, Kashif M, Haseen J, Singh A:
An overview of doping control analysis during Commonwealth Games 2010, New Delhi
124-129  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Deventer K, Pozo OJ, van Eenoo P, Delbeke FT:
Excretion studies with beta-2-agonists
130-139 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

POSTER PRESENTATION

Kochnova EA, Sobolevsky TG, Rodchenkov GM
Optimization of the hydrolysis stage for sample preparation for the steroid profile and xenobiotics analysis
140-143  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Mazzarino M, de la Torre X, Botrè F:
Comparison between reverse phase and hydrophilic interaction liquid chromatography techniques in doping analysis: a case study on phenolalkylamines
144-147  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Mazzarino M, Pernice S, de la Torre X, Botrè F:
A screening procedure for synthetic insulins by an HPLC-chip interfaced to a quadrupole time-of-flight mass spectrometer
148-151  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Reihlen P, Völker-Schänzer E, Majer B, Schänzer W:
Easy to use IEF compatible immunoaffinity purification of urine retentates
152-153  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Virus ED, Sobolevsky TG, Semenistaya EN, Dikunets MA, Rodchenkov GM:
Development and validation of a general screening method for doping substances in human urine by HPLC/Orbitrap mass spectrometry
154-157  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Cavalcanti GA, Garrido BC, Padilha MC, Mazzarino M, de la Torre X, Botrè F, Aquino Neto FR :
Detection of new exemestane metabolites by liquid chromatography interfaced to electrospray-tandem mass spectrometry
158-161  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Dubey S, Kaur T, Ahi S, Beotra A, Jain S:
Strategy for identification and confirmation of 4-methyl-2-hexaneamine in human urine in doping control
162-165 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Oueslati F, Siaï A, HentatiE, Ben Amor S, Fenina N, Loueslati MH:
Excretion study of budesonide metabolites after inhalation and oral administration using LC-ESI-MS/MS
166-169  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Sardela VF, Sardela PDO, Padilha MC, Pereira HMG, Aquino Neto FR:
Analysis of adrenergic aliphatic amines in urine for doping control
170-173  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Silva MLC, Garrido BC, Borges RM, Padilha MC, de la Torre X, Aquino Neto FR:
Designs of experiments applied to salbutamol stability study in urine and different solutions in doping control
174-177  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Simoni RE, Sardela VF, Arnaldo C,Scalco FB, Oliveira MLC, Pereira HMG, Aquino Neto FR :
Screening for dextran and HES in athletes’ urine
178-181  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Sobolevsky TG, Prasolov IS, Dikunets MA, Rodchenkov GM:
Mass spectral characterization of NBI-31772, a nonpeptide IGF-binding protein inhibitor
182-185  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Emery C, Grata E, Saugy M:
HPLC fractionation method for the isolation of endogenous urinary steroids prior to GC/C/IRMS analysis
186-189  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Jain S, Lal R, Garg T, Jamal H, Goswami M, Nimker V, Soni A, Beotra A, Kaur T:
Comparative study of endogenous steroid profile of Indian athletes with other Commonwealth Games 2010 athletes
190-194  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Wang J, Lui X, Xu Y, Wu M:
Profiling urinary steroids by GC-MSD and confirming androstenedione administration through isotope ratio mass spectrometry
195-198  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Kucherova Y, Starcevic S, Starcevic B, Ahrens BD, Butch AW:
Detection of methandienone and stanozolol metabolites: Recent experience at UCLA
199-202  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Liu X, Xing Y, Xu Y, Yang Z, Wu M:
Degradation of endogenous steroids by microorganisms
203-206  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Martínez Brito D, Correa Vidal T, García Mir V, González HernándezS, Montes de Oca R, Ledea Lozano O, Granda Fraga M:
Reference ranges of urinary steroidprofil parameters in a Latin American population
207-210  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Montes de Oca R, González Hernández S, Martínez Brito D, Correa Vidal T, Granda Fraga M:
Preliminary results on δ13C values of endogenous steroids in Cuban population
211-214 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Pop V, Vajiala I, Bican G, Picu R:
Comparative detection of stanozolol metabolites in excretion urines
215-218  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Sobolevsky TG, Prasolov IS, Rodchenkov GM:
Illicit dehydrochloromethyltestosterone: how pure is it?
219-222  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Xing Y, Liu X, Xu Y, Wu M:
Effect of different internal standards on steroids profile screening
223-226 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011  

Grebeschenko AS, Dykhal YI, Rodchenkov GM:
Characterisation of human chorionic gonadotropin reference materials by different immunoassays
227-230  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Henninge J, Hullstein I, Hemmersbach P:
Unknown peptide preparations analysed in 2010: An overview
231-234  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Ikekita A, Kaneko E, Okano M, Sato M, Kageyama S:
Validation of urinary hCG analysis using automatic immunoassay analyzer PATHFAST® based on the chemiluminescence enzyme immunoassay (CLEIA) with Magtration® technology
235-238 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011  

Jain S, Reichel C, Benetka W, Lal R, Raj A, Tyagi D, Beotra A:
Competition testing of erythropoietin (EPO) during Commonwealth Games–2010
239-242 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011  

Pussinen C, Leinonen A, Kuuranne T:
Investigation of applicability of ADVIA Centaur serum total hCG assay for detection of human chorionic gonadotropin in urine
243-246  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Trulsen LN, Øverøyen AW, Dehnes Y:
Colostrum and acute effect on serum IGF-1 levels – A pilot study
247-250  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Balgimbekova K, Balmukanov K, Januzakova A, Shaldybayeva A, Talbayev T:
Improved screening method for doping control using a GC-QQQ tandem mass spectrometer
251-254  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Donati F, Stampella A, Vemucci E, de La Torre X, Botrè F:
Can we use forensic human identification techniques to detect homologous blood transfusion in doping control? A pilot study
255-258  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Lee JE, Tran JC, Shin SM, Lee J, Kim HJ, Lee KM, Kwon OS, Kelleher NL:
Top-down proteomic analysis by use of molecular weight-based separation and online LC-FTMS
259-263  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Parr MK, Blatt C, Zierau O, Geyer H, Diel P, Schänzer W:
Insights on effects of “dietary supplement” ingredient methyl-1-testosterone
264-265  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Kwiatkowska D, Pokrywka A, Jarek A, Gorczyca D:
Potential doping substances detected in boosters in Poland
266-269  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Inthong T, Pinijprapa W, Wilairat P, Kusamran T, Anukarahanonta T, Chaikum N:
Database system for monitoring chain of custody of samplesin doping analysis
270-273 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011  

Jardines D, de la Torre X, Abate MG, Molaioni F, Colamonici C, Curcio D, Botrè F:
Longitudinal studies in steroid profiling – a multivariate approach
274-277  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Kashif M, Beotra A, Joshi M, Donati F, Nair SC, Jain S:
Homologous Blood transfusion testing in NDTL, India: A case study
278-283 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011  

Kaur T, Gotzmann A, Jamal H, Singh A, Kumar Y, Lal R, Joshi M, Beotra A, Jain S:
Experience in Sample Receiving during Commonwealth Games
284-287  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Krug O, Thomas A, Sigmund G, Walpurgis K, Beuck S, Laussmann T, Schänzer W, Thevis M:
Analysis of confiscated products with suspiciously doping relevant ingredients by SDS-PAGE, LC-MS(/MS), GC-MS/NPD
288-291  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Oliveira FFD, Garrido BC, Leal FD, Padilha MC, de la Torre X, Aquino Neto FR:
Evaluation of ambroxol as a masking agent in doping control
292-295 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Piper T, Fußhöller G, Schänzer W:
Investigations on the deconjugation processes of conjugated urinary steroids during degradation with 18O labelled water
296-299  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011

Vahermo M, Leinonen A, Yli-Kauhaluoma J:
Synthesis of three hydroxyraloxifenes as reference compounds in doping analytics
300-303  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011

Toledano R, Díaz-Plaza E, Blázquez I, Vázquez A, Villén J, Muñoz J:
Analysis of steroids by on line coupling LC-GC-MS using the TOTAD interface and a fraction collector
304-308  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Görgens C, Guddat S, Thomas A, Geyer H, Schänzer W:
Identification and quantitative determination of long-term alcohol markers ethylglucuronide and ethylsulfate in human urine by LC-MS/MS in doping control analysis
309-312 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Mazzarino M, Fiacco I, De Angelis F, Di Cicco T, de la Torre X, Botrè F:
A rapid analytical method for the detection of plasma volume expanders and mannitol based on the urinary saccharides profile
313-316 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

Völker-Schänzer E, Majer B, Kempkes R, Reihlen P, Thomas A, Thevis M, Schänzer W:
An efficient sample preparation for CERA analysis in serum
317-320 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (19). Sport und Buch Strauß - Köln 2011 

__________________________________________________________________

Manfred Donike Workshop - Proceedings of the 28th Cologne Workshop on Dope Analysis 2010
In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010

TABLE OF CONTENTS

LECTURES

Kolmonen M, Leinonen A, Kuuranne T, Pelander A, Ojanperä I:
Quantitation of morphine and its glucuronides in human urine by HILIC-TOFMS
9-16 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Möller I, Thomas A, Beuck S, Rodchenkov G, Bornatsch W, Geyer H, Schänzer W, Thevis M:
In-vitro metabolism of GW1516 and implementation of its major metabolites in routine doping controls
17-26 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010  

Kazlauskas R, Agon V:
ASDTL supplements project 2009
27-33  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010  

Parr MK, Diel P, Zierau O, Schänzer:
Investigations regarding the WADA classification of the supplement ingredient androsta-1,4,6-triene-3,17-dione
34-41 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010  

Paulsen DB, Rollins DE, Fowles R, Valiante JD, Danaceau JP:
Steroid profiling among National Football League players
42-51  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Lootens L, Van Eenoo P, Pozo OJ, Meuleman P, Leroux-Roels G, Delbeke FT:
Applications of in vivo urinary steroid detection in uPA+/+-SCID chimeric mice
52-61 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Sten T, Kurkela M, Kuuranne T, Leinonen A, Finel M:
UDP-Glucuronosyltransferases in conjugation of 5α- and 5β-androstane steroids
62-63 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010    

Parr MK, Fußhöller G, Gütschow M, Hess C, Schänzer W:
GC-MS(/MS) investigations on long-term metabolites of 17-methyl steroids
64-73 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010  

Gavrilović I, Ansell RJ, Brailsford AD, Cowan DA, Kicman AT:
Molecularly imprinted polymers selective for testosterone; potential application for GC/C/IRMS sample clean-up
74-83 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Reichel C:
The overlooked difference: Structural basis for a mass spectrometry-based dopingtest for recombinant erythropoietins
84-87  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Reichel C, Benetka E, Geisendorfer T, Scheiblhofer V,Abzieher F:
HEPARIN: More than an anticoagulant - interference of heparin on IEFPAGE of erythropoietins
88-99  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Holt RIG, Erotokritou-Mulligan I, McHugh CM, Bassett EE, Bartlett C, Fityan A, Bacon JL, Cowan DA, Sonksen PH:
The GH-2004 project: ethnicity does not affect the response of IGF-I and procollagen III N-terminal propeptide to the administration of exogenous growth hormone (GH) in amateur athletes
97-106 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Okano M, Nishitani Y, Sato M, Ikekita A, Kageyama S:
hGH isoform profiles in Japanese male subject-Reference population, rhGH administration and influence of GH secretagogue-
107-108 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010  
 
Thomas A, Kohler M, Delahaut, P, Schänzer W, Thevis, M:
Preliminary results for the development of a peptide screening method by means of LC-MS/MS
109-117  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

POSTER PRESENTATION

Harju L, Kuuranne T, Leinonen A:
Applicability of anthrone dyeing microtiter method for screening of hydroxyethyl starch and dextran – a deeper insight
118-121 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Sukhanova II, Dikunets MA, Rodchenkov GM:
Sample preparation of urine samples for liquid chromatography-tandem mass spectrometry using functionalized ferromagnetic beads
122-125  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010  

Kaur T, Dubey S, Chakraborty M, Jain S, Beotra A, Shinde CP:
Enantiomeric profiling of amphetamine and methamphetamine in sportspersons: a comparison of two chiral derivatization methods
126-129  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Sato M, Okano M, Ikekita A, Kageyama S:
Quality control of the completeness of solid-phase extraction and hydrolysis using the deutrated internal standards – Screening procedure for stimulants, narcotics, diuretics, β-blockers and other dope agents in human urine by means of UPLC®/MS/MS
130-133  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Coetzee A, van der Merwe PJ:
LC/MS/MS method for the detection of narcotic analgesics and non-steroidal anti-inflammatory drugs in human urine
134-137  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Donati F, Mazzarino M, de la Torre X, Botrè F:
A fast pre-confirmation method for the detection of HBOCs by capillary electrophoresis and UV detection
138-141  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Strano Rossi S, de la Torre X, Molaioni F, Botrè F:
Determination of sildenafil, vardenafil and tadalafil metabolites in human urine by GC/MS
142  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Sardela VF, de Oliveira PD, Pereira HMG, Aquino Neto FR:
Could a pseudoephedrine artifact lead to a misinterpretation? A pitfall in ephedrines analysis
143-146 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Marclay F, Saugy M:
Determination of nicotine metabolites in urine by LC-MS/MS: trends of smoke and smokeless products exposure in ice hockey
147-151  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010

Orlovius AK, Parr MK, Guddat S, Gütschow M, Thevis M, Schänzer W:
Detection of urinary phase-I and phase-II metabolites of ephedrine and oxilofrine by LC-MS/MS
152-155  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010  

Sobolevsky T, Prasolov I, Rodchenkov G:
Detection of synthetic cannabinoid JWH-018 in urine
156 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Möller I, Wintermeyer A, Thomas A, Krug O, Bender K, Schänzer W, Thevis M:
In-vitro metabolism of the synthetic cannabinoid JWH-018 and implementation of its major metabolites in human doping controls
157-158  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Cavalcanti GA, Leal FD, Padilha MC, Pereira HMG, de La Torre X, Aquino Neto FR:
Identification of urinary metabolites of exemestane oxidized in the exomethylene group by GC-MS
159-162 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Koch A, Sigmund G, Guddat S, Thevis M, Schänzer W:
Octopamine and biogenic amines
163-166  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Kaewklum S, Suknet N, Ditthayam K, Wilairat P, Chaikum N:
Determination of morphine in urine after the therapeutic administration of a common cough mixture, “Brown Mixture”, containing camphorated opium tincture
167-170 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Mazzarino M, Braganò MC, de la Torre X, Botrè F:
Effects of toremifene and tamoxifene on the urinary androgenic steroid profile in males and females
171-174  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Kaur T, Jain S, Bhula B, Lal R, Beotra A, Prasad GBKS:
Delta values of endogenous steroids in Indian population: Establishing Reference Ranges
175-178  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Sjöberg U, Palonek E, Garle M:
Investigation of variation of deuterated testosterone and epitestosterone internal standards in screening
179-182  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Pop V, Vâjială I, Zorio M, Lamor M:
Better recoveries in confirmation of stanozolol metabolites by LC/MS technique
183-186  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Walpurgis K, Kohler M, Thomas A, de Maree M, Mester J, Schänzer W, Thevis M:
Effects of endurance exercise on the urinary proteome analyzed by 2D-PAGE and Orbitrap mass spectrometry
187-190  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Dehnes Y, Lamon S, Lönnberg M:
EPO immunoaffinity columns – a powerful tool for purifying erythropoietin and its recombinant analogues
191-194  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010  

Okano M, Sato M, Ikekita A, Kageyama S:
Determination of growth-hormone secretagogue pralmorelin (GHRP-2) and its metabolite in human urine by means of liquid chromatography/tandem mass spectrometry
195  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Kohler M, Gotzmann A, Görgens C, Flenker U, Thevis M, Schänzer W:
Comparison of hGH serum concentrations of Caucasian and African top athletes: an ethnicity study
196-199  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Zhang L, He C, Yang S, Wu M, Xu Y, Deng J, Cao Y, Xing Y, Yang Z:
Preliminary excretion study of CERA in human urine and serums: which is the better matrix for detecting CERA abuse?
200-203  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Mazzarino M, Jardines D, Turi S, de la Torre X, Botrè F:
Effects of synthetic glucocorticoids administration on the urinary endogenous corticosteroids profile
204-207 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Beotra A, Gupta YK, Ahi S, Dubey S, Upadhyay A, Priyadarshi R, Jain S:
Preliminary studies on detection of corticosteroids in adulterated herbal drugs
208-211 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Beotra A, Ahi S, Dubey S, Upadhyay A, Jain S, Prasad GBKS:
Determination of long term metabolites of methylprednisolone using liquid chromatography tandem mass spectrometry
212-215  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Beotra A, Ahi S, Dubey S, Upadhyay A, Priyadarshi R, Jain S:
Metabolite identification and excretion profile of deflazacort on ultra performance liquid chromatography-tandem mass spectrometry
216-219  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Oueslati F, Kraiem S, Rezgui A, Saidani M, Merhabane Z, Loueslati MH:
Detection and excretion study of fluticasone propionate by liquid chromatography–mass spectrometry
220-223 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Oueslati F, Kraiem S, Jedidi J, Ben Romdhane AM, Loueslati H, Fenina N:
Study of methylprednisolone elimination profile in human urine using LC-ESI-MS/MS
224-227 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Silva, CA Pereira HMG, Aquino Neto FR:
Evidences of inter individual variability in phase II urinary excretion profile of endogenous glucocorticosteroids
228-231 In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Starcevic B, Butch A:
Use of LC/MS3 on a new quadrupole linear trap mass spectrometer and high resolution chromatography to improve detection of anabolic steroids, glucocorticosteroids, anti-estrogenic agents, and β2-agonist and their metabolites
232-235  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Strano Rossi S, de la Torre X, Botrè F:
Speeding up the analytical times: fast GC analysis for stimulants, narcotics and drugs of abuse
236  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Virus E, Semenistaya E, Sobolevsky T, Rodchenkov GM:
Investigation of electrospray photoionization (ESPI) as a new ‘universal’ ionization method for determination of doping agents by HPLC/Orbitrap mass spectrometry
237-240  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Parr MK, Westphal F, Sönnichsen FD, Geyer H, Schänzer W:
1-DHEA identification in seized dietary supplement
241-244  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010  

Sobolevsky T, Prasolov I, Rodchenkov G:
Designer stimulants recently identified on black market
245-248  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Chołbinski P, Tszyrsznic W, Wójcikowska-Wójcik B, , Pokrywka A, Kwiatkowska D:
Validation of qualitative screening method for doping substances by using UPLC-QTOF system
249-252  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Jarek A, Gorczyca D, Kwiatkowska D, Pokrywka A:
100 years of anti-doping research. In memoriam of Alfons Bukowski
253-254  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010 

Kochnova E, Shevtsova I, Sobolevsky T, Rodchenkov G:
Software for analysis of urinary and blood parameters using Bayesian approach
255-258  In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck (eds.) Recent Advances In Doping Analysis (18). Sport und Buch Strauß - Köln 2010  

________________________________________________________________

Manfred Donike Workshop - Proceedings of the 27th Cologne Workshop on Dope Analysis 2009
In: W Schänzer, H Geyer, A Gotzmann, U Mareck (eds.) Recent Advances In Doping Analysis (17). Sport und Buch Strauß - Köln 2009

TABLE OF CONTENTS

LECTURES

R. Kazlauskas, V. Agon, C. Goebel, E. Hine, G.J. Trout:
ASDTL Projects 2008
11 download

F. Botrè, X. de la Torre, M. Mazzarino, A. Tieri, K. Bush, D. Cowan:
Are liposomes masking agents? An in-progress study
21 download 

P. Van Eenoo, K. Deventer, O.J. Pozo, L. Lootens, P. Van Renterghem, F.T. Delbeke:
Results of several (small) research projects at DoCoLab in 2008
29 download 

S. Strano Rossi, D. Leone, X. de la Torre, F. Botrè:
Urinary concentrations of threshold substances: a clear enough discrimination between doping and therapy? The case of ephedrines
35 download 

K. Deventer, O.J. Pozo, P. Van Eenoo, F.T. Delbeke:
Excretion studies with thiazide diuretics
43 download 

C. Goebel, M. Sultani, R. Kazlauskas, G.J. Trout:
Detection of low level anabolic agents by LC/MS/MS with investigation of matrix effects
51 download 

Y. Kucherova, B. Starcevic, B.D. Ahrens, A.W. Butch:
Development of a high-throughput sample preparation procedure for gas chromatography-mass spectrometric analysis of various classes of doping agents using a 96-well plate format
61 download 

M.K. Parr, N. Haenelt, G. Fußhöller, U. Flenker, H. Geyer, G. Rodchenkov, G. Opfermann, W. Schänzer:
Recent steroid findings in “Designer Supplements”
71 download

P. Van Renterghem, P. Van Eenoo, H. Geyer, W. Schänzer, F.T. Delbeke:
Alternative steroid profiling: Reference ranges for urinary endogenous steroids in a caucasian population of athletes
81 download 

T. Sten, I. Bichlmaier, T. Kuuranne, A. Leinonen, J. Yli-Kauhaluoma, M. Finel:
Genetic variability and the urinary testosterone/epitestosterone ratio
91 download 

M. Tsivou, D. Livadara, D.G. Georgakopoulos, M. Koupparis, J. Atta-Politou, C.G. Georgakopoulos:
Stabilization of endogenous steroids in sport urine samples
93 download 

M.K. Parr, A. Zoellner, M. Bureik, C.A. Dragan, N. Schlörer, F. Peters, H. Maurer, W. Schänzer:
Production of metandienone longterm-metabolite, 17β-hydroxymethyl-17α-methyl-18-nor-androsta-1,4,13-trien-3-one, using S. pombe based biotransformation assay
95 download 

E. Strahm, P.-E. Sottas, D. Dvorak, M. Saugy, C. Saudan:
Steroid profiles in different ethnic groups of soccer players. A contribution to the determination of testosterone misuse in sports
97 download 

M. Kohler, A. Thomas, K. Walpurgis, L. Horta, W. Schänzer, M. Thevis:
Detection of proteases and their proteolysis and autolysis products in urine by LC-MS
107 download 

YANG, Sheng; HE, Chunji; DONG, Ying; WANG, Shan; XU, Youxuan; WU, Moutian; JING, Zimeng; WU Qinyong; ZHU Huijuan; PAN Hui; GONG Fengying; GU Feng:
The use of “Kit A” for detection of rhGH doping
117 download 

M. Kohler, K. Püschel, A. Thomas, W. Schänzer, M. Thevis:
Detection of recombinant growth hormone in plasma by a 2D-PAGE method: an update
127 download 

HE, Chunji, YANG, Sheng, DONG, Ying, LI, Shengwei, XU, Youxuan, WU, Moutian:
Homologous blood transfusion (HBT) test by cytometry for Chinese and non-Chinese population
137 download 

N. Monfort, R. Ventura, A. Latorre, V. Belalcazar, M. López, J. Segura:
Phthalate exposure: new clue to suspect illicit blood transfusion
147 download 

S. Beuck, N. Schlörer, M. Kamber, W. Schänzer, M. Thevis:
Hypoxia-inducible factor (HIF) pathway as target for doping purposes and mass spectrometric characterisation of orally available model HIF-stabilizers
155 download 

C. Reichel, T. Geisendorfer:
Detection of Epo-doping in blood
165 download 

S. Lamon, S. Giraud, L. Egli, J. Smolander, M. Jarsch, K.-G. Stubenrauch, A. Hellwig, M. Saugy, N. Robinson:
How to detect blood doping with subcutaneous or intravenous injection of C.E.R.A.
169 download

POSTER PRESENTATION

A. Vonaparti, E. Lyris, I. Angelis, I. Panderi, M. Kouparis, L. Bonnington , C. Georgakopoulos:
Screening of prohibited substances in human urine by a single LC-ESI-TOF-MS analysis
181 download 

G. Bican, V. Pop, C. Colev, M. Lamor, I. Vâjialã:
Optimization and validation of the quantification of morphine from urine by triple quadrupole LC/MS2
185 download 

V. Gougoulidis, T. Piper, U. Flenker, W. Schänzer:
Comparison of normal-phase and reverse-phase HPLC clean up for 13C/12C
analysis of endogenous urinary steroids
189 download

M. Kolmonen, A. Leinonen, T. Kuuranne, I. Ojanperä:
Combined solid phase extraction procedure for extensive doping screening
193 download 

G. Muñoz, J.A. Muñoz-Guerra, F.A. Rodríguez:
RRLCTM an alternative method to speed up the LC-MS/MS analysis, without lost of separation efficiency
197 download 

E.D. Virus, E.N. Semenistaya, T.G. Sobolevsky, G.M. Rodchenkov:
Implementation of HPLC/Orbitrap mass spectrometry as screening method for doping control
201 download 

S. Strano Rossi, X. de la Torre, F. Botrè:
A rapid method for the extraction and enantiomeric separation of amphetamine-type stimulants
203 download 

M. Mazzarino, X. de la Torre, F. Botrè, N. Gray, D. Cowan:
A rapid screening LC-MS/MS method based on conventional HPLC pumps for the analysis of low molecular weight xenobiotics: application to doping control analysis
207 download

G.J. Murray, J.P. Danaceau:
Simultaneous extraction and detection of diuretics, beta-blockers and other xenobiotics in human urine by HPLC-MS/MS and UPLC-MS/MS
211 download 

W. Tszyrsznic, D. Stanczyk, M. Pasik, D. Kwiatkowska, A. Pokrywka:
Validation of rapid UPLC/MS/MS qualitative screening method for detection of β-blockers in urine samples
217 download 

C. Gómez, R. Bergés, J. Segura, R. Ventura:
Detection of mesocarb metabolites excreted free and conjugated with sulphate in human urine by UPLC-MS/MS
221 download 

G. Sigmund, M. Thevis, A. Koch, S. Guddat, W. Schänzer:
Determination of methoxyphenamine in doping control analyses
225 download 

V.F. Sardela, M.R.T. Motta, M.C. Padilha, H.M.G. Pereira, F.R. Aquino Neto:
Detection of sibutramine metabolites as N-TFA and N-TFA, O-TMS derivatives
229 download 

G. Fußhöller, W. Schänzer:
Improved steroid profiling using GC tandem mass spectrometry – Preliminary results –
233 download 

T. Piper, U. Flenker, W. Schänzer:
Determination of 13C/12C ratios of endogenous urinary steroids excreted as sulphates: method validation and reference population
237 download 

A. Beotra, S. Ahi, S. Jain:
Urinary excretion profile of main mono hydroxylated metabolites of stanozolol by HPLC-ESI (+)-MS/MS
241 download 

A. Leinonen, J. Apajalahti, T. Moisander, O. Siikanen, T. Kuuranne, M. Lauraeus:
Studies with steroids and fecal contamination of urine samples
245 download 

B. Salema, J.N. Ruivo, X. de la Torre, M. Sekera, L. Horta:
Oxandrolone excretion: effect of caffeine dosing
249 download

M. Galésio, J.L. Capelo-Martìnez, X. de la Torre, F. Botrè:
Speeding up the process: ultrasounds in sample preparation for steroids analysis
253 download 

S. Kraiem, F. Oueslati, J.Hached, I. Trabelsi, A. Ben Romdhane, M.H. Loueslati:
Contribution of ion-trap mass spectrometry in the determination of fragment origin of steroids
257 download 

H. Geyer, U. Mareck, N. Haenelt, W. Schänzer:
Atypical steroid profiles in connection with ethanol findings in urine
261 download 

J.L. Du Preez, E Grobbelaar, P.J. Van Der Merwe, P.N. Badenhorst:
Stability of blood baseline parameters under various storage conditions
265 download 

A. Gotzmann, J. Grosse, W. Schänzer:
Detection of total ß-hCG in doping control – A case study
269 download 

A. Lüdke, U. Flenker, S. Lüdke, W. Schänzer:
Influence of storage on the mobility values of human erythropoietin
273 download 

A. Thomas, W. Schänzer, M. Thevis:
Determination of insulin to C-peptide ratios as marker for a surreptitious insulin application
277 download 

P. Anielski, D. Schwenke, S. Monecke, E. Jacobs, D. Thieme:
Bacterial proteases in urine samples – effects on EPO analysis?
281 download 

F. Garribba, S. Turi, X. de la Torre, F. Botrè:
Technical improvement of the screening method for the detection of erythropoietins in urine
285 download 

M. Mazzarino, F. Donati, X. de la Torre, F. Botrè, R.J. Huskie, D. Cowan:
Development and validation of a rapid method for enzymatic digestion of HBOCs utilizing microwave irradiation
289 download 

A. Chammakhi, S. Kraiem, H. Loueslati:
Study of r-Met-hu- G- CSF (recombinant Granulocyte colony-stimulating factor) by isoelectric focusing and RP-HPLC
293 download 

P. Kaliszewski, D. Michalak, A. Pokrywka, D. Kwiatkowska:
Validation of differential immunoassays of hGH Isoforms: KIT 1 and 2
297 download 

A. Lüdke, S. Lüdke, E. Völker-Schänzer, W. Schänzer:
Detection of Mircera in blood plasma using isoelectric focusing combined with magnetic beads purification
301 download 

N. Suknet, N. Saardpun, P. Wilairat, T. Kusamran, T. Anukarahanonta:
Determination of prednisolone and prednisone in urine after therapeutic administration of an ophthalmic solution
305 download 

A. Beotra, S. Ahi, S. Dubey, A. Upadhyay, S. Jain:
Application of liquid chromatography tandem mass spectrometry for the detection of ten long-term metabolites of Prednisolone
309 download 

C. Rautenberg, D. Thieme:
Structural investigation of candidate proteins in urine samples with demethylation activity
313 download

B. Salema, J. Ruivo, X. de la Torre, M. Sekera, L. Horta:
Cologne protocol efficacy: Two unusual case studies
317 download

C. Howe, C. Goebel, R. Kazlauskas:
Current and potential doping agents identified in customs and police seizures in Australia
321 download

A. Pokrywka, W. Trzyrsznic, D. Kwiatkowska:
Problems of the use of pseudoephedrine by athletes
325 download 

M. Vahermo, A. Leinonen, T. Suominen, M. Kolmonen, T. Kuuranne, J. Yli-Kauhaluoma:
Synthesis of 17-dihydroexemestane as a reference compound in doping control
327 download 

J.O. Thörngren, M. Garle:
Determination of sulphate- and glucuronide-conjugated anabolic steroids by direct injection of urine to UPLC-MS/MS
331 download       

______________________________________________________________

Manfred Donike Workshop - Proceedings of the 26th Cologne Workshop on Dope Analysis 2008 

In: W Schänzer, H Geyer, A Gotzmann, U Mareck (eds.) Recent Advances In Doping Analysis (16). Sport und Buch Strauß - Köln 2008    

TABLE OF CONTENTS

LECTURES

H.M.G. Pereira, M.C. Padilha, R.M.A. Bento, T.P. Cunha, N.A.G. Lascas, F.R. Aquino Neto:
Analytical and logistic improvements for the doping control analysis at the 2007 Pan-American Games
11 download

R. Kazlauskas:
WADA list
21 download 

P. Van Eenoo, W. Van Thuyne, O. Pozo- Mendoza, K. Deventer, L. Lootens, P. Van Renterghem, F.T. Delbeke:
Results of several (small) research projects at DoCoLab in 2007
33 download 

M. Tsivou, D. Livadara, D.G. Georgakopoulos, M. Koupparis, J. Atta-Politou, C.G. Georgakopoulos:
Preservation of urine doping control samples – Preliminary results
41 download

K. Deventer, P. Van Eenoo, Guy Baele, O.J. Pozo, F.T. Delbeke:
Stability study of thiazide diuretics
51 download 

M. Thevis, M. Kohler, N. Schlörer, G. Fußhöller, W. Schänzer:
Screening for quinolinone-derived selective androgen receptor modulators using GC-MS and LC-MS/MS
59 download

T. Kuuranne, A. Leinonen, W. Schänzer, M. Kamber, R. Kostiainen, M. Thevis:
Aryl-propionamide-derived selective androgen receptor modulators: Liquid chromatographic-tandem mass spectrometric characterization of the in vitro synthesized metabolites for doping control purposes
69 download 

S. Guddat, M. Thevis, A. Thomas, W. Schänzer:
Rapid screening of polysaccharide based plasma volume expanders dextran and hydroxyethyl starch in human urine by liquid chromatography – tandem mass spectrometry
71 download 

M.K. Parr, H. Geyer, M. Gütschow, N. Haenelt, G. Opfermann, M. Thevis, W. Schänzer:
New steroids on the “supplement” market
73 download 

J. Henninge, I. Hullstein, I. Liborg, M. Lindøe, P. Hemmersbach:
Longitudinal monitoring of steroid profiles – Improvements to the analytical procedure
83 download

T. Kuuranne, K.-H. Pystynen, R. Kostiainen, A. Leinonen, M. Thevis, W. Schänzer:
Metabolism of “new” anabolic steroids: Development of in vitro methodology in metabolite production and analytical techniques
89 download 

L. Lootens, P. Van Eenoo, O.J. Pozo, P. Meuleman, G. Leroux-Roels, F.T. Delbeke:
Validation of the metabolism of steroids in uPA+/+-SCID mice with humanized liver
99 download 

J.P. Danaceau, M. S. Morrison, M.H. Slawson:
Quantitative confirmation of testosterone and epitestosterone in human urine by LC-Q-ToF mass spectrometry for doping control
107 download 

O.J. Pozo, W. Van Thuyne, P. Van Eenoo, K. Deventer, F.T. Delbeke:
Direct quantification of steroid glucuronides by liquid chromatography tandem mass spectrometry
117 download 

C.J. Walker, D.A. Cowan, V.H.T. James, J.C.Y. Lau, A.T. Kicman:
Evaluation of the extent of urinary excretion of 19-norandrosterone in women and considerations regarding norethisterone administration
127 download 

O.J. Pozo, P. Van Eenoo, K. Deventer, L. Lootens, S. Grimalt, J.V. Sancho, F. Hernandez, F.T. Delbeke:
General guidelines for the CID fragmentation of 3-keto-anabolic steroids
131 download 

W. Van Thuyne, P. Van Eenoo, W. Van Gansbeke, F.T. Delbeke:
Implementation of DRS in doping control
141 download 

U. Mareck, H. Geyer, U. Flenker, T. Piper, M. Thevis, W. Schänzer:
Population based reference ranges and additional screening marker for the improvement of the detection of dehydroepiandrosterone misuse
149 download 

T. Piper, U. Flenker, W. Schänzer:
Determination of 13C/12C ratios of endogenous urinary steroids: Method validation, reference population and implication for doping control purposes
151 download 

H. J. Tobias, G. L. Sacks, Y. Zhang, J. T. Brenna:
Progress towards comprehensive 2d gas chromatography combustion isotope ratio mass spectrometry (GCxGCC-IRMS)
153 download

U. Flenker, S. Lüdke, U. Güntner, W. Schänzer:
Which factors control 13C/12C-ratios of urinary steroids?
163 download 

Y. Zhang, H.J. Tobias, J.T. Brenna:
Uniform isotopic standards for gas chromatography combustion isotope ratio mass spectrometry of steroids
171 download 

T. Piper, U. Flenker, W. Schänzer:
Determination of D/H ratios of endogenous urinary steroids: Method validation and first results
181 download 

P. Hemmersbach, Y. Dehnes, F. Mikkelsen, A. Lund, A. Solheim, L. Stølan, M. Drange,:
Individual blood profiling – A means of improving the fight against doping
191 download 

V. Agon, C.J. Howe, R. Kazlauskas, G.J. Trout:
Aspects of the detection of insulin abuse in sport
201 download 

A. Thomas, H. Geyer, M. Kamber, W. Schänzer, M. Thevis:
Mass spectrometric determination of gonadotrophin-releasing hormone (GnRH) in human urine for doping control purposes by means of LC-ESIMS/MS
211 download 

C. Goebel, J. Simpson, D. Marinelli, C.J. Howe, G.J. Trout, R. Kazlauskas, D.J. Handelsman:
Measurement of LH in urine. A test for doping?
213 download

M. Okano, A. Ikekita, M. Sato, S. Kageyama:
Analysis of growth hormone-releasing peptides for doping control
223 download 

M. Kohler, K. Püschel, D. Sakharov, A. Tonevitskiy, W. Schänzer, M. Thevis:
Detection method for recombinant human growth hormone based on 2D-PAGE
233 download 

E. Llop, R. Gutiérrez-Gallego, J. Segura, J. Mallorqui, J.A. Pascual:
Glycan profiling discriminates between rEPO δ (Dynepo®, produced in human cells) and rEPO α/β (produced in CHO cells)
245 download 

M. Kohler, C. Ayotte, P. Desharnais, U. Flenker, S. Lüdke, A. Lüdke, M.Thevis, E. Völker-Schänzer, W. Schänzer:
Relative mobility values for the discrimination of endogenous and recombinant EPO on SDS gels
257 download 

C. Reichel, R. Kulovics, V. Jordan, M. Watzinger, T. Geisendorfer:
SDS-PAGE of recombinant and endogenous erythropoietins: benefits and limitations of the method for application in doping control
267 download 

S.A. Appolonova, M.A. Dikunets, G.M. Rodchenkov:
Indirect detection of rHuEPO and synacthen administration in human urine
269 download 

POSTER PRESENTATION

G. Bican, V. Pop, R. Subaşu, M. Lamor, I. Vâjială:
Improved detection of banned doping substances by triple quadrupole LC/MS² technique
281 download 

G. Fußhöller, W. Schänzer, D. Krumwiede:
Improved screening of anabolic steroids in human urine using a new GC-triple quadrupole mass spectrometer - Preliminary results –
285 download

P. Anielski:
Disintegration of hair samples vs. methanol extraction – Influences on the analysis of anabolic steroids
289 download 

M.A. Dikunets, S.A. Appolonova, G.M. Rodchenkov:
Comprehensive screening of urinary free fraction using HPLC-MS/MS
293 download 

T. Sobolevsky, I. Kachala, S. Bolotov, G. Rodchenkov:
Detection of L- and D-stereoisomers of methamphetamine in urine following derivatization with menthyl chloroformate
297 download 

G. Sigmund, M. Thevis, A. Koch, S. Guddat, W. Schänzer:
Methods for the detection of tuaminoheptane
301 download 

E. Palonek, R. Rylin, M. Garle, G. Rasmanis:
Screening for β-blockers in urine with on-line extraction and LC-MSMS
detection
305 download 

J.O. Thörngren, F. Österwall, M. Garle:
Stereoselective confirmation of amines by chiral derivatization and UPLC-MS/MS
309 download 

M. Mazzarino, M.C. Braganò, S. Turi, F. Botrè:
LC-ESI-MS/MS screening method for simultaneous detection in human urine of glucocorticoids, diuretics, some stimulants, some beta2-agonists, some beta-blockers, anti-oestrogens and new designer steroids
313 download 

M. Vahermo, A. Leinonen, T. Suominen, T. Kuuranne, J. Yli-Kauhaluoma:
Synthesis of mesocarb metabolites as reference compounds for doping analytics
317 download 

R.E. Simoni, F.B. Scalco, L.N.L.F. Gomes, C.F. Arnaldo, T.M. Moutinho, J.F. Paulino, S.F. Silva, M.L.C. Oliveira, F.R. Aquino Neto:
Screening for HES in human urine and possible application for dextran
321 download 

V. Gougoulidis, G. Sigmund, U. Flenker, W. Schänzer:
Determination of gamma-butyrolactone (GBL) -A tool for the detection of the administration of gamma-hydroxybutyric acid (GHB)-
325 download 

M. Mazzarino, F. Botrè:
Fast screening for the detection of HES and dextran
329 download 

F. Oueslati, M. Maatki Z. Osman, , H. Loueslati:
Identification by LC-ESI- MS/MS of new clomifene metabolites in urine
333 download 

T. Sobolevsky, E. Virus, E. Semenistaya, V. Kachala, I. Kachala, G. Rodchenkov: Orastan-A:
Structural elucidation and detection in urine
337 download 

M.C. Padilha, H.M.G. Pereira, P.F. Aguiar, C.M.A. Silva, F.R. de Aquino Neto:
Improvement in detection of 3’OH-stanozolol in human urine using a new ion trap mass spectrometry system
341 download 

S.C. Voss, U. Flenker, B. Majer, W. Schänzer:
Stability tests for haematologic parameters in an anti-doping context
345 download 

S. Lamon, N. Robinson, P.E. Sottas, H. Henry, M. Kamber, P. Mangin, M. Saugy:
Possible origin of undetectable EPO in urine samples
347 download 

J. Henninge, I. Hullstein, G. Hagelin, P. Hemmersbach:
Identification of growth hormone releasing hexapeptide (GHRP-6) in an unknown pharmaceutical preparation
351 download 

C. Goebel, G.J. Trout and R. Kazlauskas:
Implementation of insulin analysis by ASDTL
355 download 

Y. Dehnes, M. Borgen, M. Lönnberg, P. Hemmersbach:
Shifted isoelectric profiles of endogenous erythropoietin possibly due to different physiological origin
359 download 

F. Donati, F. Botrè:
Using Advia 120 hematological analyzer as a fast screening method for HBOCs detection in human whole blood
363 download 

A. Beotra, R.I. Madhusudhana, G. Sandeep, S. Jain, J.S. Sandhu:
Detectability of glucocorticosteroid formulations available in Indian market following different routes of administration
367 download 

V. Pop, G. Bican, M. Lamor:
Flunisolide – Triamcinolone acetonide. MS differentiation in positive and in negative ionization mode. LC differentiation.
371 download 

R. Jazwiec, D. Kwiatkowska, A. Pokrywka, D. Stanczyk:
Use of porous graphite packed columns in analysis of doping control samples for glucocorticosteroids
375 download 

H. Kraiem, F. Oueslati, S. S. Ben Amor, N. Fenina, H. Loueslati:
Structural elucidation of seven prednisolone metabolites by LC-ESI- MS/MS using a PGC column
379 download 

S. Nimsoongnern, D. Pinthong, S. Plasen, P. Wilairat, T. Kusamran, T. Anukarahanonta:
The effect of butea superba roxb., a Thai traditional medicine, on endogenous steroid levels in males
383 download  

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Manfred Donike Workshop - Proceedings of the 25th Cologne Workshop on Dope Analysis 2007
In: W Schänzer, H Geyer, A Gotzmann, U Mareck (eds.) Recent Advances In Doping Analysis (15). Sport und Buch Strauß - Köln 2007   

TABLE OF CONTENTS

LECTURES

R.I.G. Holt, I. Erotokritou-Mulligan, D. Cowan, C. Bartlett, E.E. Bassett, E.E. Muller, A. Sartorio, P.H. Sönksen:
The GH-IGF-2012 project: the use of growth hormone (GH)-dependent markers in the detection of GH abuse in sport: Intra-individual variation of IGF-I and P-III-P
11 download

M. Kohler, K. Püschel, W. Schänzer, M. Thevis:
Mass spectrometric identification of human pituitary growth hormone variants
21 download 

R. Kazlauskas:
Supplements & WADA List
31 download

P. Van Eenoo, L. Lootens, W. Van Thuyne, K. Deventer, O. Pozo-Mendoza, F.T. Delbeke:
Results of several (small) research projects at DoCoLab in 2006
41 download

M. Mazzarino, F. Botrè:
How safe are our internal procedures? Some preliminary experimental evidence on the problem of “lab-oriented” potential masking agents
49 download 

P. Van Eenoo, A. Spaerkeer, F.T. Delbeke:
Measurement uncertainty – a practial top-down approach
59 download 

M. Thevis, J.A. Loo, R.R. Ogorzalek Loo, W. Schänzer:
Recommended criteria for the mass spectrometric identification of target peptides and proteins (< 8 kDa) in sports drug testing
67 download 

A. Kazlauskas:
Being expert in the 21st century
69 download 

E. Grobbelaar, P.J. van der Merwe, J.H.W. Potgieter:
Urinary concentrations of inhaled and orally administered Salbutamol
79 download 

U. Mareck, N. Haenelt, M.K. Parr, S. Guddat, A. Thomas, M. Thevis, W. Schänzer:
Direct quantification of Salbutamol in human urine by means of LC-MS/MS
89 download 

M.K. Parr, A. Orlovius, S. Guddat, M. Gütschow, M. Thevis, W. Schänzer:
Sulfoconjugates of heavy volatile nitrogen containing doping substances for improved LC-MS/MS screening
97 download 

R. Montes de Oca Porto, M.T. Correa Vidal, A. Rosado Pérez, M. Granda Fraga:
Confirmatory procedure of Ephedrines by gas chromatography-mass spectrometry. Migration of the trimethylsilyl group in the N-acetyl-O-trimethylsilyl derivatives
103 download 

B. Vitoriano, X. de la Torre:
Study of Clomiphene metabolism by LC/MS/MS
113 download 

M. Okano, A. Ikekita, M. Sato, S. Kageyama:
Detection of Mepitiostane in doping analysis
123 download 

H. Geyer, U. Flenker, U. Mareck, P. Platen, T. Piper, A. Schmechel, Y. Schrader, M. Thevis, W. Schänzer:
The detection of the misuse of Testosterone gel
133 download 

M.K. Parr, G. Opfermann, T. Piper, N. Schlörer, G. Fußhöller, A. Thomas, M. Thevis, W. Schänzer:
Characterisation of steroid metabolites recently detected in doping control analyses
143 download

O.J. Pozo, K. Deventer, P. Van Eenoo, F.T. Delbeke:
Endogenous interferences in the detection of anabolic steroids by liquid chromatography tandem mass spectrometry
153 download

A. Leinonen, J. Apajalahti, T. Moisander, O. Siikanen, T. Kuuranne, M. Lauraeus:
Experiments on production of “endogenous Boldenone”
163 download 

T. Piper, M. Hebestreit, U. Flenker, H. Geyer, W. Schänzer:
A method to determine δ13CVPDB-values of trace amounts of Boldenone and its main metabolite
169 download 

Ying Zhang, G.L. Sacks, J.T. Brenna:
Fast Gas Chromatography Combustion Isotope Ratio Mass Spectrometry
179 download

A. Cawley, R. Kazlauskas, G. Trout, A. George:
Metabolic 13C fractionation: What it means for doping control
189 download 

A. Cawley, R. Kazlauskas, G. Trout, A. George, R. Weatherby, S. Marshall-Gradisnik:
Compound specific detection of endogenous steroid abuse in athletes
199 download 

U. Flenker, F. Hülsemann, V. Gougoulidis, G. Sigmund, W. Schänzer:
Elucidation of original and metabolic sources of Ephedrines by stable isotope analysis
209 download 

A.I. Silva Junior, H.M.G. Pereira, A. Casilli, F.R. Aquino Neto:
Analytical challenges in doping control: GC x GC: is it an option?
217 download 

W. Van Thuyne, P. Van Eenoo, F.T. Delbeke:
Possibilities of SIM/scan analysis in doping control
227 download 

X. Kioussi, A. Fragkaki, A. Vonaparti, M. Stamou, M. Demesticha, E. Lyris, Y.S. Angelis, G. Tsoupras, B. Wuest, M.W.F. Nielen, I. Panderi, M. Koupparis, C. Georgakopoulos:
Time-of-Flight Mass Spectrometry: Unification of analytical methods and preventive screening in doping control analysis
235 download 

J.O. Thörngren, F. Östervall, M. Garle:
A new approach for screening, verifying and confirmation of prohibited doping substances
245 download 

O.J. Pozo, W. Van Thuyne, P. Van Eenoo, K. Deventer, F.T. Delbeke:
Use of liquid chromatography tandem mass spectrometry (LC-MS/MS) and gas chromatography (GC-MS) in the detection of Fluoxymesterone metabolites
253 download

M. Thevis, M. Kohler, W. Schänzer:
Mass spectrometry of new growth promoting drugs: Hydantoin-derived selective androgen receptor modulators and growth hormone secretagogues
263 download 

R. Gutiérrez Gallego, A. Pinyot Comelles, Z. Nikolovski, J. Bosch, J. Segura:
Growth hormone secretagogues
273 download 

J. Maurer, M. Kohler, W. Schänzer, M. Thevis:
Identification of proteolytic enzymes in human urine
283 download 

A. Thomas, M. Thevis, P. Delahaut, A. Bosseloir, W. Schänzer:
Identification and determination of degradation products of human insulin and its long acting synthetic analogues in urine by means of ESI-LC-MS/MS
293 download 

P. Desharnais, C. Ayotte:
Towards the screening of urinary EPO by SDS-PAGE analysis
303 download 

P.E. Groleau, P. Desharnais, C. Ayotte:
Characterization of glycopeptides released from pmol levels of recombinant erythropoietin by nanoflow HPLC-Chip electrospray ionization coupled to ion trap mass spectrometry
305 download 

C. Reichel:
Identification of Zinc-alpha-2-glycoprotein binding to clone AE7A5 antihuman Epo antibody by means of nano-HPLC and high-resolution accurate mass ESI-MS/MS
315 download 

J. Segura, C. Fillat, D. Andreu, J. Llop, O. Millan, B.G. de la Torre, Z. Nikolovski, V. Gomez, N. Andreu, A. Pinyot, R. Castelo, J.D. Gispert, J.A. Pascual:
Non invasive molecular imaging of gene expression potentially useful for doping control: Pilot study in cells and animals
325 download 

G.J. Trout, M. Sultani, C. Goebel, C.J. Howe, R. Kazlauskas:
Miscellaneous projects in sports drug testing at the National Measurement Institute, Australia, 2006 or, “an ASDTL Assortment”
327 download 

POSTER PRESENTATION

S: Hudson, S. Maynard, M. Harrison:
Can multiple instrumental analyses be replaced by a single analysis?
339 download 

T.F.H. Bovee, J.C.W. Rijk, A.A.C.M. Peijnenburg, M.W.F. Nielen:
A specific yeast androgen bioassay for the detection of androgens, anti-androgens and pro-androgens in supplements and urine
343 download 

M. Maatki, S. Bouabdallah, S. Kraiem, A. Toumi:
Optimization and validation of analytical method for anabolic steroids in nutritional supplements by GC/MS
347 download 

A. Gotzmann, S.C. Voß, W. Schänzer:
Abbott IMx® total β-hCG-kit versus Roche Elecsys® hCG STAT-kit: Validation and performance comparison
351 download

R. Pootrakronchai, M. Kaewklum, P. Wilairat, T. Kusamran; T. Anukarahanonta:
Method validation for d,l-isomers of Methamphetamine and Amphetamine by GC/MS
355 download 

M. Okano, M. Sato, A. Ikekita, S. Kageyama:
A rapid ultra-performance liquid chromatography (UPLC™) /mass spectrometry – Applications in doping control
359 download 

K. Deventer, O.J. Pozo, W. Van Thuyne, P. Van Eenoo, F.T. Delbeke: Screening and confirmation of ritalinic acid in urine by LC-MSn
363 download 

K. Koehler, H. Geyer, S. Guddat, A. Orlovius, M.K. Parr, M. Thevis, J. Mester, W. Schänzer:
Sibutramine found in chinese herbal slimming tea and capsules
367 download 

P. Gärtner, K. Hofbauer, G. Gmeiner, T. Geisendorfer:
Synthesis and characterization of a metabolite of Tamoxifen
371 download 

S. Jain, T. Kaur, R. Khanduja, S. Shweta, A. Beotra:
Correlation of steroid profile data on GC-MSD with delta values on GC-IRMS after administration of Testosterone preparations to healthy volunteers with low and high T/E ratio
375 download 

R. Picu, M. Zorio, M. Lamor:
The influence of hCG administration on the steroidic profile
381 download 

J. Grosse , C. Rautenberg , L. Wassill, D. Ganghofner, D. Thieme:
Degradation of doping-relevant steroids by Rh. Erythropolis
385 download 

S. Torrado, M. Roig, M. Farré, J. Segura, R. Ventura:
Metabolic profile in human urine after oral administration of 19-Norandrostenediol as a nutritional supplement
389 download 

G. Fußhöller, U. Mareck, A. Schmechel, W. Schänzer:
Long-term detection of metandienone abuse by means of the new metabolite 17ß-hydroxymethyl-17a-methyl-18-norandrost-1,4,13-trien-3-one
393 download 

S. Guddat, W. Schänzer, P. Wachsmuth, M. Thevis:
Doping control screening procedure for Trenbolone analogues in human urine by LC-(APCI)-MS/MS
397 download

A. Leinonen, T. Kuuranne, T. Moisander, K. Rautava:
Artificial urine as sample matrix for calibrators and quality controls in determination of Testosterone to Epitestosterone ratio
401 download 

Y. Dehnes, M. Borgen, P. Hemmersbach:
Enzymatic digestion of EPO
405 download 

I. Holländer, I. Bajla, M. Minichmayr, G. Gmeiner, C. Reichel:
GASepo: Project summary 2004 2006
409 download 

A. Kniess, E. Ziegler, D. Thieme, R. K. Müller:
A hGH application study: Issues related to valid detection parameters
413 download 

H.A. Dimopoulou, T. Theodoridis, V. Galea, V. Christopoulou-Cokkinou, M.H. Spyridaki, C.G. Georgakopoulos:
ISO/IEC 17025 Sysmex R-500 hematology reticulocyte analyzer validation
417 download 

L. Avois, I. Bailloux, A. Desmarchelier, A. Lahaussois, N. Méchin, M. Saugy, J. de Ceaurriz:
Synthetic glucocorticosteroids administration: Urinary excretion of Triamcinolone acetonide
419 download 

M.T. Correa Vidal, D. Martínez, R. Montes de Oca, K. Alonso Pérez, M. Granda Fraga:
Differences in urine excretion of Hydrocortisone (Cortisol) following two administration routes
425 download 

C. Bakkene, J. Henninge, I. Hullstein, P. Hemmersbach:
Urinary levels of glucocorticoids resulting from different routes of administration
429 download 

W. Van Thuyne, F.T. Delbeke:
Medication use in sports
433 download 

M. Plata Andrés, A. Frutos Sicilia, C. Turmo Blanco, J. Muñoz-Guerra Revilla, A. F. Rodríguez Cano, C. Rodríguez Bueno:
An information security management system for the doping control laboratory of Madrid: Achieving ISO 27001:2005 standard
437 download 

S. Lüdke, M. Sauer, M. Paul, W. Schänzer:
The Cologne import information system: A tool to highlight long term trends in the Black Market for drugs and doping substances
441 download  

______________________________________________________________

Manfred Donike Workshop - Proceedings of the 24th Cologne Workshop on Dope Analysis 2006
In: W Schänzer, H Geyer, A Gotzmann, U Mareck (eds.) Recent Advances In Doping Analysis (14). Sport und Buch Strauß - Köln 2006  

TABLE OF CONTENTS

LECTURES

H. Geyer, K. Köhler, U. Mareck, M.K. Parr, W. Schänzer, M. Thevis:
Cross-contaminations of vitamin- and mineral-tablets with metandienone and stanozolol
11 download

M. Mazzarino, M. C. Braganò, F. Botrè:
An LC/MS-MS screening method for synthetic glucocorticoids based on pharmacological structure-activity relationships
17 download 

A. Gotzmann, M. Thevis, M. Bredehöft, W. Schänzer:
Ciclesonide (Alvesco®) – a new glucocorticosteroid for inhalative treatment
27 download 

C.J. Walker, D.A. Cowan, N.F. Taylor, A.T. Kicman:
Determination of xenobiotic glucocorticoids in urine by gas chromatography–mass spectrometry
35 download

M.E. Touber, M.C. van Engelen, C. Georgakopoulus, J.A. van Rhijn, M.W.F. Nielen:
Multi-detection of corticosteroids in sports doping and veterinary control using high resolution liquid chromatography / time-of-flight mass spectrometry
45 download 

C. Goebel, G.J. Trout, R. Kazlauskas:
Progress in the simplification of drug screening
47 download 

M. Mazzarino, F. Molaioni, S. Riggi, F. Rossi, F. Botrè:
Speeding up the rate of antidoping analysis: some perspectives on the use of microwave assisted extraction and fast chromatography
55 download 

M. Kolmonen, A. Leinonen, A. Pelander, I. Ojanperä, T. Kuuranne:
Screening of doping agents using liquid-chromatography/time-of-flight mass spectrometry
65 download

K. Deventer, P. Van Eenoo, F.T. Delbeke:
Improved clean-up for the detection of hydroxyethylstarch (HES)
71 download 

P. Van Eenoo, A. Spaerkeer, L. Lootens, W. Van Thuyne, K. Deventer, F.T. Delbeke:
Results of several (small) research projects at DoCoLab in 2005
79 download 

M. Thevis, M. Kamber, W. Schänzer:
Identification of metabolically stable selective androgen receptor modulators (SARMs) in human urine
87 download 

S. Appolonova, P. Baranov, G. Rodchenkov:
Metabolism of non-steroidal phytoestrogens: ipriflavone and 5-methyl-7-hydroxy-isoflavone
91 download 

U. Mareck, G. Fußhöller, H. Geyer, N. Haenelt, M. Thevis, M. Kamber, R. Brenneisen, W. Schänzer:
Temporal indication of marijuana use
101 download 

V. Sizoi, T. Sobolevsky, S. Appolonova, G. Rodchenkov:
Prosidol: new piperidine-type narcotic analgesic
111 download 

W. Van Thuyne, P. Van Eenoo, F.T. Delbeke:
Comprehensive screening method for the detection of narcotics and stimulants using single-step derivatization
121 download 

R. Kazlauskas:
Micellaneous projects in sports drug testing at the National Measurement Institute, Australia, 2005
129 download

G. Rodchenkov, T. Sobolevsky, V. Sizoi:
New designer anabolic steroids from internet
141 download 

C. Ayotte, D. Goudreault, D. Cyr, J. Gauthier, P. Ayotte, C. Larochelle, D. Poirier:
Characterisation of chemical and pharmacological properties of new steroids related to doping of athletes
151 download

T. Kuuranne, A. Leinonen, M. Thevis, W. Schänzer, K.-H. Pystynen, R. Kostiainen:
Metabolism of “new” anabolic steroids: development of in vitro methodology in metabolite production and analytical techniques
161 download 

M. Kohler, M.K. Parr, G. Opfermann, W. Schaenzer:
Metabolism of 4-hydroxyandrostenedione and 4-hydroxytestosterone
169 download 

L. Zhang, Y. Zhang, M. Xie, X. Liu, J. Wang, Y. Yan, X. Wang, Y. Li, M. Wu:
Excretion study with different preparations of 1-testosterone
179 download

P. Van Eenoo, P. Mikulcikova, W. Van Thuyne, K. Deventer, F.T. Delbeke:
Detection of 19-norandrosterone after ingestion of the oral contraceptives norethisterone acetate and lynestrenol and ethylestrenol
189 download 

Y. Schrader, M. Thevis, W. Schänzer:
Quantitative determination of metabolic products of 19-norandrostenediol in human plasma using gas chromatography / mass spectrometry
199 download 

L.G. Mackay, D. Burke, F.H. Liu, N. Sousou, J. Cuthbertson, V.V. Vamathevan, R. B. Myors:
Production and certification of a reference material for the measurement of 19-norandrosterone in human urine
203 download 

L. Ekström, J. Jakobsson, M. Garle, A. Rane:
Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism
211 download

W. Schänzer, H. Geyer, G. Fußhöller, N. Halatcheva, M. Kohler, M.-K. Parr, S. Guddat, A. Thomas, M. Thevis:
Mass spectrometric identification and characterization of a new long-term metabolite of metandienone
217 download 

L.G. Mackay, D. Burke, F.H. Liu, N. Sousou, J. Cuthbertson:
Development of a high-accuracy IDMS method for 19-norandrosterone in urine for the certification of a reference material
219 download

G. Fußhöller, A. Koch, U. Mareck, A. Thomas, A. Schmechel, G. Sigmund, M. Thevis, W. Schänzer:
New sample preparation procedure for the confirmation of stanozolol and its metabolites by means of GC/MSMS and LC/ESI-MSMS
229 download 

M. Thevis, S. Horning, A. Makarov, W. Schänzer:
Mass spectrometric characterization of efaproxiral (RSR13) and stanozolol using electrospray ionization with high resolution/high accuracy mass spectrometry
239 download 

M.K. Parr, G. Opfermann, W. Schaenzer:
Detection of new 17-alkylated anabolic steroids on WADA 2006 list
249 download 

J.T. Brenna, G.L. Sacks, Ying Zhang, M.E. Brenna:
Data analysis in GCC-IRMS
259 download

A.T. Cawley, R. Kazlauskas, G.J. Trout, J. Tjoa, T. Huynh, A.V. George:
GC-C-IRMS analysis of endogenous reference compounds
267 download 

C.Ayotte, C. Romiguière, A. Fakirian, U. Flenker, M. Hebestreit, T. Piper, W. Schänzer:
The usefulness of GC/C/IRMS in determining the origin of low levels 19-NA– application in routine analysis
277 download 

T. Piper, V. Gougoulidis, U. Flenker, W. Schänzer:
Presentation of the IRMS results of suspicious samples with elevated T/EpiT ratios in 2005
289 download 

U. Flenker, M. Hebestreit, T. Piper, W. Schänzer:
A new, effective and robust method to couple gas chromatography and isotope ratio mass spectrometry
299 download 

R.I.G. Holt, I. Erotokritou-Mulligan, C.M. McHugh, D. Cowan, C. Bartlett, E.E. Bassett, P.H. Sönksen:
The GH-2004 project: the use of growth hormone (GH)-dependent markers in the detection of GH abuse in sport
307 download 

G. Such Sanmartín, R. Gutiérrez Gallego, J. Bosch, D. Andreu, J. Segura:
5 kDa and 17 kDa Hydrolysis Products of Human Growth Hormone
317 download 

R. Stempfer, K. Vierlinger, A. Kriegner, G. Gmeiner, C. Nöhammer:
Growth hormone elicits specific effects on blood cell gene expression levels
327 download 

S. Giraud, C. Georgakopoulos, J. de Ceaurriz, C. Ayotte, J. Segura, M. Saugy:
Homologous blood transfusion proficiency tests
335 download

S.C. Voß, B. Majer, W. Schänzer, M. Thevis:
Validation and signal amplification of a flow cytometric method to detect homologous blood transfusion
343 download 

D. Marinelli, V. Agon, C. Howe, A. Stenhouse, M. Sillence, G.J. Trout, R. Kazlauskas:
EPO immunoaffinity columns for purification
345 download 

C. Reichel, I. Holländer, G. Gmeiner:
Improvement in the background correction of Epo IEF images
353 download 

M. Bredehöft, M. Thevis, P. Delahaut, M. Kamber, W. Schänzer:
Detection of Synacthen® in human plasma with LC-ESI-MS/MS after immunoaffinity purification
363 download 

A. Thomas, M. Thevis, P. Delahaut, A. Bosseloir, W. Schänzer:
Qualitative determination of rapid acting insulin analogues in urine by means of LC-MS/MS
367 download 

POSTER PRESENTATION

C. Rautenberg, J. Grosse, D. Thieme, L. Wassill, D. Ganghofner, R.K. Mueller:
Testosterone degradation induced by Rhodococcus eryth. and Comamonas test.
379 download 

M. Okano, M. Sato, Y. Nishitani, C. Omori, A. Ikekita:
Analysis of carbonic anhydrase inhibitors in doping control
383 download

A.T. Cawley, R. Kazlauskas, G.J. Trout, A.V. George, R.P. Weatherby, S. Marshall-Gradisnik, A.J. Silk:
4’OH-androstenedione (4’OH-ADIONE): a confirmatory marker of androstenedione abuse in athletes
387 download

J. Wang, Y. Xu, Y. Zhang, X. Liu, H. Zhang, M. Wu:
Testosterone with different delta value
391 download

C. Borges, N. Miller, M. Shelby, M. Hansen, C. White, M. Slawson, D. Crouch:
Analysis of a challenging subset of WADA-banned steroids and antiestrogens by LC/MS/MS
395 download

S. Guddat, G. Sigmund, A. Thomas, G. Opfermann, M. Thevis, W. Schänzer:
Detection of meclofenoxate and its degradation products dimethylaminoethanol and p-chloro-phenoxyacetic acid
399 download

G. Sigmund, M. Thevis, A.K. Schiffer, W. Schänzer:
Screening for N-desmethyl- and N-bisdesmethyl metabolites of Sibutramine using liquid chromatography-tandem mass spectrometry
403 download

M. Abidi, S. Karkeni, N. Ben Hamida, A. Toumi:
Study of the behavior of the steroid profile under hydrolysis conditions after 4-androstenedione oral administration by GC/MS
407 download

D. Kwiatkowska, Z. Obmiński, A. Pokrywka, E. Turek-Lepa, R. Jaźwiec, R. Grucza:
Sport-related differences in the urinary T/Et and A/E ratios among polish athletes
411 download

N. Suknet, S. Nimsoongnern, P. Wilairat, T. Kusamran, T. Anukarahanonta:
Preliminary results on the carbon isotope ratios of endogenous steroids in urine collected from asian countries
415 download

K. Koehler, M.K. Parr, H. Geyer, C. Bode, W. Schaenzer:
Serum testosterone and urinary steroid profiles after administration of a zinc supplement
419 download

J. Son, D.-H. Kim, M.-J. Kang, M. Ho Choi:
Screening and confirmation analyses of urinary plasma volume expanders, dextran and HES, in doping control
423 download

Sook Yi Mun, A.M. Normaliza, A. Manaf, A. A. Latiff:
Rapid screening of plasma volume expanders using Benedict’s solution
427 download

P.E. Groleau, P. Desharnais, C. Hamelin, C. Ayotte:
Purification of EPO from urine retentates prior to IEF detection
431 download

P. Desharnais, P.E. Groleau, C. Hamelin and C. Ayotte:
Intermediate neuraminidase activity: a possible link toward suspicious or “effort-like” EPO isoelectric profiles
435 download

H.M. G. Pereira, S.B. Ramos, M.Aurélio Dal Sasso, E.S.C. Poças, M.C. Padilha, L.N.F. Gomes, F. Radler de Aquino Neto:
Study of endogenous profile of hCG in male Brazilian athletes
439 download

E. Hine, C. Goebel, G. Trout, R. Kazlauskas:
The use of isotopically labelled internal standards for hCG analysis
443 downlad

S. Yang, C. Zhang, Y. Cai, X. Qian, M. Wu:
The potential molecular marker in distinguishing exogenous recombinant human growth hormone using MALDI-TOF-MS/MS
447 download

F. Oueslati, N. Ben Hamida, H. Trabelsi, A. Toumi:
Investigation on the rearrangement of triamcinolone
451 download

H.M.G. Pereira, M.C. Padilha, M.A.S. Marques, L.N.F. Gomes, F. Radler de Aquino Neto:
Systematic study of glucocorticosteroids O-TMS derivatives
455 download

G. Bican, V. Pop, M. Lamor, I. Vâjialã, G. Vâjialã, B. Saglam, S. Önol, A. Temizer:
The separation of betametasone from dexametasone by using LC/MS/MS technique with triple quadrupole and excretion studies of dexamethasone after intramuscular administration
459 download

L. Brooker, C. Goebel, R. Kazlauskas, G. Trout, A. George:
Confirmation of triamcinolone acetonide use by LC-MS/MS
463 download

M. Abidi, S. Karkeni, N. Ben Hamida, A. Toumi:
Study of a case of WADA criteria shortage in the passage from GC/MS analysis to GC/IRMS one and investigation of an additional positivity criterion related to the second analysis
467 download

S. Hudson, S. Maynard:
Unblocking the data dam
471 download

P.J. van der Merwe, P.M. van Zyl, G. Joubert:
The effect of multiple doses of Tribulus Terrestris on serum LH and testosterone levels in healthy males
475 download

C. Judkins, C. Russell, M. Jennings, P. Watson:
A crossover study of 19-nor-androstenedione contamination in sports supplements: preliminary findings
477 download

W. Van Thuyne, F.T. Delbeke:
Czech supplements: the story continues
481 download

S. Torrado, R. Ventura, M. Farré, J. Segura:
Determination of 19-norandrostenediol and its metabolites in human plasma after oral administration of a nutritional supplement
485 download

G. Opfermann, M. Kohler, G. Fußhöller, M.K. Parr, G. Sigmund, W. Schänzer:
Comparison of uncertainties: the standard deviations of the method of two calibration curves with different preparatory steps
489 download  

______________________________________________________________

Manfred Donike Workshop - Proceedings of the 23rd Cologne Workshop on Dope Analysis 2005
In: W Schänzer, H Geyer, A Gotzmann, U Mareck (eds.) Recent Advances In Doping Analysis (13). Sport und Buch Strauß - Köln 2005 

TABLE OF CONTENTS

LECTURES

F. Botrè, R. Borrelli, C. Colamonici, F. Garribba, M. Mazzarino, F. Rossi::
Optimizing the cost/benefit ratio of the laboratory procedures: a way to match the WADA requirements (with the help of microwaves)
11 download

K. Deventer, P. Van Eenoo, F.T. Delbeke:
Extension of an existing screening method for diuretics with beta-blocking
agents
21 download 

A. Gotzmann, M. Thevis, M. Bredehöft, W. Schänzer:
Glucocorticosteroids in routine doping analysis: metabolism and detection of fluticasone-17-propionate
29 download

C. Goebel, G.J Trout, R. Kazlauskas:
Corticosteroids by LC/MS/MS – a minimalist approach
39 download 

E. Palonek, F. Österwall, M. Garle:
Screening for corticosteroids in urine with on-line extraction and LC-MSMS detection
47 download 

P. Van Eenoo, P. Mikulcíková, K. Deventer, W. Van Thuyne, F.T. Delbeke:
Metabolism, excretion and detection of androst-4-ene-3,6,17-trione
57 download 

M.K. Parr, G. Fusshoeller, G. Opfermann, M. Kohler, M. Hebestreit, W. Schaenzer:
Synthesis of reference compounds for the identification of metabolites of 4-hydroxytestosterone
65 download 

A. Kazlauskas, K. Crawford:
Perceptions of anti-doping scientific work
75 download 

M. Machnik, G. Sigmund, W. Schänzer:
Antidepressants in sport – therapeutic use or doping abuse?
85 download 

N. Pizarro, M. Farré, S. Abanades, M. Segura, J. Ortuño, M. Pujadas, J. Segura, R. de la Torre:
Relevant metabolic and pharmacokinetic aspects of ecstasy consumption
95 download 

W. Van Thuyne, F.T. Delbeke:
Did caffeine use in sports change after the removal from the doping list ?
105 download 

G. Opfermann, U. Mareck, H. Geyer, S. Guddat, A. Koch, M. Kohler, M. Thevis, W. Schänzer:
Detection of exemestane and its metabolites using GC-MS and LC-MS-MS: a comparative study for screening purposes
115 download 

U. Mareck, H. Geyer, S. Guddat, N. Haenelt, A. Koch, G. Opfermann, M. Thevis, W. Schänzer:
Screening for anastrozole in doping analysis
127 download 

R. Kazlauskas:
Miscellaneous projects 2004
137 download 

M. Thevis, H. Geyer, U. Mareck, W. Schänzer:
Screening for synthetic steroids in human urine by LC-ESI-MS/MS
147 download 

M.W.F. Nielen, T.F.H. Bovee:
The potential of bioassays and time-of-flight mass spectrometry in urine testing for banned and designer steroids
157 download 

J. Hughes, C. Borges, M. Slawson, J. Taccogno, D. Crouch, B. Wuest:
Detection and confirmation of anabolic steroids and metabolites in urine using routine accurate mass API-TOF LC/MS
159 download 

T. Kuuranne, M. Ellfolk, K. Kuoppasalmi, A. Leinonen, W. Schänzer, M. Thevis, L. Hintikka, R. Kostiainen, C. Georgakopoulos:
Steroid glucuronides – synthesis and development of liquid chromatographic / mass spectrometric analysis in the detection of doping in sport
169 download 

F. Molaioni, M. G. Abate, R. Alocci, M. Mazzarino, F. Rossi, F. Botrè:
Urine stability, steroid profile and T/E ratio: towards an index of sample degradation
179 download 

M. Mazzarino, M.C. Braganò, F. Donati, F. Botrè:
The effect of the oral administration of propyphenazone on the urinary concentration of testosterone and 19-nortestosterone metabolites
189 download 

S. Simões, B. Vitoriano, C. Manzoni, X. de la Torre:
5-Alpha reductase inhibitors detection in doping analyses
199 download 

M. Hebestreit, U. Flenker, G. Fußhöller, U. Güntner, H. Geyer, U. Mareck, W. Schänzer:
Mission (im)possible? Gas chromatography/ combustion/isotope ratio mass spectrometry of trace amounts of urinary norandrosterone
209 download 

C. von Kuk, U. Flenker, U. Güntner, F. Hülsemann, W. Schänzer:
Influence of changes in diet on the dynamics of 13C/12C-ratio in selected urinary steroids. Part I: study design, 13C/12C-ratio of applied foodstuffs and effect on anthropometrical data
219 download 

U. Flenker, C. von Kuk, U. Güntner, F. Hülsemann, V. Gougoulidis, W. Schänzer:
Influence of changes in diet on the dynamics of 13C/12C in selected urinary steroids: diet free from cholesterol
227 download 

C. Goebel, C. Alma, G. Trout, R. Kazlauskas:
HBOC detection - progress since 2000
235 download 

M. Thevis, H. Geyer, U. Mareck, W. Schänzer:
Detection of oral antidiabetic agents in human urine by LC-ESI-MS/MS
243 download 

M. Thevis, A. Thomas, P. Delahaut, A. Bosseloir, W. Schänzer:
Qualitative determination of synthetic insulin analogues in human plasma by means of LC-MS/MS
245 download

M. Zorzoli:
Blood monitoring in anti-doping setting
255 download 

S. Giraud, N. Robinson, P. Mangin, M. Saugy:
Homologous blood transfusion detection. A new world in anti-doping field: flow cytometry
265 download 

R. Gutiérrez Gallego, R. Ramírez Llanelis, J. Segura:
The bitter-sweet difference between recombinant and endogenous hCG - preliminary data
275 download 

R. Abellán, R. Ventura, M. Pilar Sardà, A.F. Remacha, F.A. Rodríguez, J.A. Pascual, J. Segura:
Physiological effects of intermittent hypoxia in triathletes and detection of EPO abuse
287 download

F. Lasne, L. Martin, J. de Ceaurriz :
Active urine and detection of recombinant erythropoietin
297 download 

A. Khan, S.T. Truong, E.J. Breen, K. Nelson, C. Howe, N.H. Packer:
New urinary EPO drug testing method using two-dimensional gel electrophoresis
305 download 

E. Giménez, V. Belalcazar, J.A. Pascual, R. Gutiérrez-Gallego, J. Segura, C. de Bolós:
Polyclonal antibodies aimed to differentiate EPO and NESP
315 download 

M. Sato, J. Nozaki, T. Shimazaki, Y. Takao, Y. Otsuka, M. Ueki:
Detection of hGH doping by means of isoform selective immunoassays-3. Isoform ratio of hGH in serum and new approach to automate array detection of proteins by means of flowcytometry
327 download 

C.J. Howe, G. J. Trout, R. Kazlauskas:
Development of a test for recombinant human growth hormone
337 download 

C. Howe, C. Goebel, G. Trout, R. Kazlauskas:
Equine growth hormone
347 download 

M. Thevis, R.R. Ogorzalek-Loo, J.A. Loo, M. Bredehöft, W. Schänzer:
Probing for characteristics of growth hormone by LC-ESI-MS/MS
355 download 

POSTER PRESENTATION

V. Pop, G. Vâjialã, M. Lamor, G. Bican, M. Tone:
Comparative analytical techniques for the identification of some androgenic anabolic steroids (GC/MS – LC/MS/MS)
369 download 

A. Ikekita, M. Okano, M. Ueki, Y. Honda:
Trilogy; ionization procedures to detect corticosteroids abuse by means of LC/MS
375 download 

R. Bergés, M. Solé, R. Ventura, J. Segura:
Detection of low molecular weight doping agents in urine ultrafiltrates obtained during EPO determination
379 download 

R. Gutiérrez Gallego, G. Such-Sanmartin, J. Segura:
A microtiter assay to detect the presence of glucose-based plasma volume expanders in urine
383 download 

G. Fusshöller, U. Mareck, W. Schänzer:
Improved detection of 3‘hydroxystanozolol using 3‘hydroxystanozolol-d3 as internal standard
387 download 

A. Leinonen, T. Moisander, K. Vuorensola, T. Kuuranne, T. Kotiaho, R. Ketola, R. Kostiainen:
Gas chromatographic/mass spectrometric determination of ethisterone in urine by liquid-phase microextraction with in-fiber silylation
391 download 

L. Avois, M. Saugy: Optimization of morphine and codeine hydrolysis in urine by experimental design for GC-MS quantification purpose
395 download 

F. Garribba, M. Mazzarino, F. Rossi, F. Botrè:
Recovery of polar and non polar substances from the ultrafiltrate fraction of the EPO aliquot
399 download 

S. Kaewklum, M. Kaewklum, R. Pootrakronchai, U. Tassana, P Wilairat, T. Anukarahanonta:
Detection of mitragynine and its metabolite in urine following ingestion of leaves of mitragyna speciosa korth
403 download 

S. Jain, A. Beotra, T. Kaur:
A case study: detection of 1-testosterone in urine by GC-MSD
407 download 

S.M.S. Simões, M. Calçada, L. Horta, X. de la Torre:
Methylprednisolone detection in urine following local and oral administrations
411 download 

M. Bredehöft, M. Thevis, W. Schänzer:
Excretion study: betamethasone-17,21-propionate ointment and possible metabolites in man analysed with LC-ESI-MS/MS
415 download 

S. Guddat, M. Thevis, U. Mareck, H. Geyer, W. Schänzer:
Identification of cyclodextrins by liquid chromatography–ESI-tandem mass spectrometry
419 download 

S. Voss, A. Gotzmann, H. Geyer, U. Mareck, W. Schänzer:
Evaluation of LH concentration in male and female urines. Effects of a single LH application on the steroid profile
423 download 

V. Belalcazar, J.A. Pascual, S. Abanades, M. Farré, R. de la Torre:
Stability of EPO in urine stabilized by sodium azide
427 download 

I. Holländer, I. Bajla, M. Minichmayr, G. Gmeiner, C. Reichel:
GASepo: system for analysis of images generated in EPO doping-control proteomics
433 download 

O. De Hon, S.S. Sterk:
The Netherlands security system nutritional supplements elite sports (NZVT) - general characteristics of NZVT
437 download 

K.L. Wubs, S.S. Sterk, L.A. van Ginkel, R.W. Stephany:
The Netherlands security system nutritional supplements elite sports - stimulants analysis in food supplements (NZVT)
441 download 

H.A. Herbold, S.S. Sterk, L.A. van Ginkel, R.W. Stephany:
The Netherlands security system nutritional supplements elite sports (NZVT) (Pro)-Hormone analysis in food supplements for the NZVT
445 download 

C. Rautenberg, J. Grosse, P. Anielski, D. Thieme, P. Hemmersbach, H.S. Lund, R.K. Mueller:
Aspects of the in-situ formation of 19-norsteroids
449 download 

D. Kwiatkowska, A. Pokrywka, R. Jazwiec, E. Turek-Lepa, B. Starosciak, S. Lewandowska-Pachecka, J. Pachecka, R. Grucza:
The research of microbiological stability in anti-doping samples
453 download 

A. Beotra, S. Jain, T. Kaur:
Dope testing during 1st Indo–Pak Games in India
457 download 

L. Avois, C. Schweizer, M. Saugy:
Concentration of nandrolone metabolites in urine after the therapeutic administration of an ophthalmic solution
461 download 

M. Mazzarino, M.C. Braganò, F. Garribba, F. Rossi, F. Botrè:
The idea of a threshold value for synthetic glucocorticoids: urinary excretion studies following different routes of administration
465 download 

P. Anielski, D. Thieme, J. Große, R. K. Müller:
Hair analysis of several anabolic substances
469 download 

U. Sjöberg, E. Palonek, M. Garle:
Results from screening for anabolic androgenic steroids outside sport
475 download 

H. Geyer, I. Gorius, N. Dreyer, U. Mareck, M. Thevis, W. Schänzer:
Investigation about the effects and the detection of finasteride
479 download 

H.S. Lund, H. Alstad, P. Fedorcsàk, R. Storeng, P. Hemmersbach:
Endogenous nandrolone production: studies in granulosa cells from patients with polycystic ovary syndrom (PCOS)
483 download 

A. De la Cal, G. Muñoz, S. Vargas, J.A. Muñoz-Guerra, F.A. Rodriguez, C. Rodriguez:
A fast quantification of salbutamol using automated SPE and liquid chromatography mass spectrometry
487 download 
____________________________________________________________

Manfred Donike Workshop - Proceedings of the 22nd Cologne Workshop on Dope Analysis 2004
In: W Schänzer, H Geyer, A Gotzmann, U Mareck (eds.) Recent Advances In Doping Analysis (12). Sport und Buch Strauß - Köln 2004 

TABLE OF CONTENT

LECTURES

F. BOTRÈ, L. AMENDOLA, R. BORRELLI, C. COLAMONICI, F. GARRIBBA:
The Effect of the WADA List on the Activity of the Antidoping Laboratories: Reconsidering the “Traditional” Organization of the GC-MS Screenings
15 download

W. VAN THUYNE, F.T. DELBEKE:
Caffeine Use In Sports: An Overview before the Removal from the Doping List
27 download 

K. DEVENTER, F.T. DELBEKE:
Excretion Studies with Corticosteroids
37 download 

M. MAZZARINO, F. ROSSI, F. BOTRÈ:
Effect of the Systemic vs. Inhalatory Administration of Synthetic Glucocorticoids on the Urinary Steroid Profile
45 download 

A. GOTZMANN, M. THEVIS, U. MARECK, M. BREDEHÖFT, S. GUDDAT, W. SCHÄNZER:
LC-MS/MS Analysis of Glucocorticosteroids: First Experiences with Therapeutic Use Exemption in Routine Doping Analysis
55 download 

U. MARECK, M. THEVIS, S. GUDDAT, A. GOTZMANN, M. BREDEHÖFT, H. GEYER, W. SCHÄNZER:
Comprehensive Sample Preparation for Anabolic Steroids, Glucocorticosteroids, Beta-Receptor Blocking Agents, Selected Anabolic Androgenic Steroids and Buprenorphine in Human Urine
65 download 

P.J. VAN DER MERWE, E. GROBBELAAR:
Nutritional Supplements - The South African Scenario
69 download 

M.K. PARR, H. GEYER, G. OPFERMANN, W. SCHÄNZER:
Prescription Drugs and New Anabolic Steroids in Nutritional Supplements
71 download 

ZHANG YINONG, LIU XIN, WU MOUTIAN, WANG JINGZHU, ZHANG HUYUE:
Analytical Data of 1-Testosterone and the Preliminary Results of Excretion Study with 1-Testosterone
81 download 

H. GEYER, A. GÜLKER, U. MARECK, M.K. PARR, , W. SCHÄNZER: Some Good News from the Field of Nutritional Supplements
91 download 

A. KAZLAUSKAS, K. CRAWFORD: The Emerging Practice of Global Scientific Work
99 download 

Y. SCHRADER, W. SCHÄNZER:
Plasma Levels of 19-Norsteroids after Administration of Oral and Sublingual Norandrostenedione
109 download 

H. GEYER, U. FLENKER, U. MARECK, F. SOMMER, W. SCHÄNZER: Preliminary Results regarding the detection of the misuse of testosterone gel
121 download 

M.K. PARR, G. OPFERMANN, W. SCHÄNZER:
Analytical Properties of 4-Hydroxysteroids and some Esters
129 download 

D.H. CATLIN, MICHAEL H.. SEKERA, B.D. AHRENS, B. STACEVIC, Y-C. CHANG, C.K. HATTON:
Discovery and Detection of a Designer Steroid
139 download 

M. THEVIS, G. OPFERMANN, W. SCHÄNZER:
Mass Spectrometric Characterization of Synthetic Steroid Derivatives
141 download 

M. MACHNIK, M. THEVIS, C. VON KUK, S. GUDDAT, W. SCHÄNZER:
Gestrinone Analysis in Equine Urine by LC-MS/MS
149 download

S. DAUFELDT, A. ALLÉRA:
SteroCheckTM: A Bioassay for the Determination of Agonistic and Antagonistic Steroid Hormone Activities
159 download 

B. WÜST, M. THEVIS:
High Resolution Quantitative Analysis of Beta-2-Agonists in Human Urine by LC/MS Using the Agilent LC/MSD TOF
169 download 

D. THIEME, P. ANIELSKI, J. GROSSE, P.HEMMERSBACH, H.LUND, C. RAUTENBERG:
Kinetic of In-situ Demethylation of Deuterated Endogenous Steroids in Urine Samples
177 download 

P. VAN EENOO, A. SPAERKEER, F.T. DELBEKE:
Stability Studies of Selected Doping Substances in Methanolic Solution
189 download 

M. THEVIS, G. OPFERMANN, O. KRUG, W. SCHÄNZER:
Synthesis of Stably Deuterated Ephedrines and Theobromine Promoted by N-Methyl-N-Trimethylsilyltrifluoroacetamide
195 download 

S. GUDDAT, M. THEVIS, W. SCHÄNZER:
Detection and Quantification of the Plasma Volume Expander Dextran in Human Urine
197 download 

U. MARECK, G. SIGMUND, G. OPFERMANN, H. GEYER, W.SCHÄNZER:
Screening on Letrozole and its Metabolite in Doping Analysis
203 download 

N. SAARDPUN, S. NIMSONGNERN, T. CHUTTHONG, R. POOTRAKRONCHAI, D. PINTHONG, T. KUSAMRAN, P. WILAIRAT AND T. ANUKARAHANONTA:
The Excretion Study of Exemestane in Man
211 download 

C. VON KUK, W. SCHÄNZER:
Characteristics and Abundance of Various Conjugated Metabolites Commending the Analysis of the Sulphate Fraction
221 download

A. CAWLEY, R. KAZLAUSKAS, G. TROUT, A. GEORGE:
Pure and Applied Aspects of Carbon Isotope Ratio Analysis in Doping Control
231 download 

WANG JINGZHU, WU MOUTIAN, ZHANG YINONG, LIU XIN, ZHANG HUYUE:
Delta Values of Different Steroids
241 download 

U. GÜNTNER, U. FLENKER, C. AYOTTE, M. UEKI, W. SCHÄNZER:
D/H-Isotope Analysis of Endogenous Steroids - First Results
251 download 

R. KAZLAUSKAS:
Miscellaneous Projects for 2003
261 download 

R. GUTIÉRREZ GALLEGO, J. SEGURA, J. BOSCH, G. SUCH, D. ANDREU, M. UEKI, M. IRIE:
Growth Hormone in Biological Fluids: What about Using Surface Plasmon Resonance?
269 download 

R. ABELLAN, R. VENTURA, S. PICHINI, A.F. REMACHA, M.P. SARDA, S. DI CARLO, A. BACOSI, R. PACIFICI, J.A. PASCUAL, P. ZUCCARO, J. SEGURA:
Indirect Biomarkers of rhGH and rhEPO misuse. Factors affecting their Measurement in Serum Samples
279 download 

V. BELALCAZAR, R. GUTIÉRREZ, E. LLOP, J. SEGURA, J.A. PASCUAL:
Assessing the Charge Heterogeneity of Different Erythropoietins
289 download 

E.LLOP, R. GUTIÉRREZ, V. BELALCÁZAR, G.J. GERWIG, J.P. KAMERLING, J. SEGURA, JA. PASCUAL:
Structural Features of EPO and Analogues: Glycosylation Profiles
297 download 

K. NELSON, G. TROUT, C. HOWE, R. KAZLAUSKAS:
The Effects of Exercise on Urinary Erythropoietin Levels and Isoform Distribution
309 download 

A. KHAN, J. GRINYER, S. TRUONG, E. BREEN, C. HOWE, B. HERBERT, K. WILLIAMS, N. PACKER:
Detection of Recombinant Erythropoietin in Urine by Two-dimensional Gel Electrophoresis
317 download 

POSTER PRESENTATION

M. HEBESTREIT, U. FLENKER, W. SCHÄNZER:
Hardware-considerations for Purification of Steroids by Normal-Phase HPLC for GC-C-IRMS
323 download 

A. LEINONEN, K. VUORENSOLA, L.-M. LEPOLA, T. KUURANNE, T. KOTIAHO, R. KETOLA, R. KOSTIAINEN:
Applicability of Liquid-phase Microextraction (LPME) for Sample Preparation of Free Anabolic Steroids in Urine
329 download 

S. STRANO ROSSI, F. MOLAIONI, F. BOTRÈ:
Application of Solid Phase Microextraction for the Determination of Stimulants, Narcotics and other Doping Agents Excreted Free in Urine
335 download 

G. MUÑOZ, J. MUÑOZ-GUERRA, F.A. RODRÍGUEZ, C. RODRÍGUEZ:
An Automated SPE-LC/MS Method Permits a Highly Selective Analysis of Anabolic Steroids, Beta-Blocking Agents and Stimulants
341 download 

R. BERGES, R. VENTURA, C. JIMENEZ, J. SEGURA:
Incorporation of Acidic Doping Agents to Routine Screening Procedures
347 download 

H.M. GUALBERTO PEREIRA, M.A. SÍPOLI MARQUES, F.R. AQUINO NETO:
Analysis of Glucocorticosteroids by GC-MS in Doping Control
353 download 

G. BICAN, G. VÂJIALÃ, M. LAMOR, V. POP, B. CHITIMIA:
GC/MS Separation and Quantitation of Ephedrines
359 download 

S. KARKENI, S. BOUABDALLAH, H. TRABELSI, K. BOUZOUITA:
Quantification at Low Concentration of 19-Norandrosterone in Human Urine by GC/MS/MS/MS and GC/HRMS. A Comparative Study
365 download 

L. AVOIS, H.S. LUND, P. HEMMERSBACH, M. SAUGY:
Rapid Screening of HES in Urine with Colorimetric Detection
371 download 

M. MAZZARINO, D. LONGO, F. ROSSI, F. BOTRÈ:
Perspectives of Capillary Electrophoresis Using Dynamic Capillary Coating for Routine Screening Procedures in Antidoping Analysis
377 download 

S.A. APPOLONOVA, N.V. ARHIPENKO, V.A. SEMENOV:
Use of Ion Trap Liquid Chromatography-Mass Spectrometry for Detection and Confirmation of Stanozolol Metabolites at Trace Levels in Doping Analysis
383 download 

R. MONTES DE OCA, A. RODRIGUEZ, D. MARTINEZ, T. CORREA:
Excretion Study of Danazol. New Metabolites Proposed for Doping Control
389 download 

D. KWIATKOWSKA, K. CHROSTOWSKI, A. POKRYWKA, E. PARTYKA, B. WÓJCIKOWSKA – WÓJCIK, E. TUREK-LEPA, D. STANCZYK, D. MICHALAK, R. GRUCZA:
Aldosterone Concentrations in the Blood Plasma and in the Urine Samples as the Biological Marker of Anabolic Adrogenic Steroids (AAS) Abuse
395 download 

M.A. SÍPOLI MARQUES, H.M. GUALBERTO PEREIRA, M.C. DE OLIVEIRA, I.B. TALHAS, F.R. AQUINO NETO:
Validation of the Determination of Tibolone in Human Urine and Saliva Using Gas Chromatography – Mass Spectrometry for Doping Control and Clinical Studies
403 download 

S.A. APPOLONOVA,V.A. SEMENOV: Validation of Liquid Chromatography – Electrospray Ionization Ion Trap Mass Spectrometry Method for the Determination of Mesocarb in Human Plasma and Urine
409 download 

S.H. DENIATI, A. HAPSARI, L. ROSALINA:
Gas Chromatographic - Mass Spectrometric Identification of Codeine, Morphine, and 6-Monoacetyl Morphine in Human Urine as Trimethylsilyl Derivatives
415 download 

ZHOU XIN, CUI KAIRONG,WU MOUTIAN:
Structural Elucidation of the Metabolite of Tamoxifen in Human Urine
421 download 

T. INTHONG, U. TESANA, S. LOHWITHEE, P. WILAIRAT, T, ANUKARAHANONTA:
Effect of Multiple High Doses of DHEA on Urinary Steroids Excretion
427 download

F. ROSSI, M. MAZZARINO, M.C. BRAGANÒ, F. BOTRÈ:
Effect of Amino Acid Supplementation on the Urinary Steroid Profile Concentrations
433 download 

M. OKANO, M. SATO, M. UEKI:
Five Year Follow-up Study on Steroid Profiles in Individuals -Stability and Intra-individual Variation of d-values-
439 download 

G. STÜBIGER, M. MARCHETTI, C. REICHEL, G. GMEINER, G. ALLMAIER:
Towards the Identification/Verification (Search for Molecular Substructure Markers) of Recombinant EPOs Applied in Doping Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS)
445 download

R. ABELLAN, R. VENTURA, S. PICHINI, R. DI GIOVANNANDREA, J.A. PASCUAL, M. BELLVER, R. OLIVE, R. PACIFICI, P. ZUCCARO, J. SEGURA:
Serum Levels of EPO in Elite Athletes
453 download 

DENG JING, YANG SHENG, YANG ZHIYONG,WUMOUTIAN:
Statistics of Blood Test in 5th National Urban Games, China 2003
459 download 

R. ABELLAN, R. VENTURA, S. PICHINI, J.A. PASCUAL, M. BELLVER, R. DI GIOVANNANDREA, R. OLIVE, R. PACIFICI, P. ZUCCARO, J. SEGURA:
Serum Concentrations of P-III-P and IGF-I in Selected Populations of Athletes
465 download 

W. VAN THUYNE, F.T. DELBEKE:
Nutritional Supplements and Doping: Non-labelled Multiple Prohormones in a Czech Nutritional Supplement
471 download 

P. ANIELSKI, D. THIEME, A. SCHLUPP, F. ELLENDORFF, R.K. MUELLER:
Incorporation of Nandrolone in Horse Hair – Importance of Sweat
479 download 

H.S. LUND, I.M. LARSEN, P. HEMMERSBACH, P. ANIELSKI, C. RAUTENBERG, J. GROSSE, D. THIEME:
Inter-Laboratory Study of Low Levels of Nandrolone Metabolites
485 download

R.K.R. TAYLOR, A.T. CAWLEY, R. KAZLAUSKAS, G.J. TROUT, A.V. GEORGE:
Validity of Carbon Isotope Ratio Measurements for Decomposed Urine Samples
491 download 

M. LAMOR, I. VAJIALA, G. VAJIALA:
The Quantification of Prohormones in Nutritional Supplements
497 download 

_____________________________________________________________

Manfred Donike Workshop - Proceedings of the 21st Cologne Workshop on Dope Analysis 2003
In: W Schänzer, H Geyer, A Gotzmann, U Mareck (eds.) Recent Advances In Doping Analysis (11). Sport und Buch Strauß - Köln 2003

TABLE OF CONTENT

LECTURES
C. GOEBEL, G. TROUT, R. KAZLAUSKAS:
A Rapid Screening Method for Diuretics Using Automated SPE and LC-MS-MS
13 download

K. DEVENTER, F.T DELBEKE:
Validation of a Qualitative Screening Method for Corticosteroids by Liquid Chromatography Tandem Mass Spectrometry
23 download 

A. GOTZMANN, M. BREDEHÖFT, M. THEVIS, W. SCHÄNZER: Detection of Prednisolone, Prednisone and 20-Dihydroprednisolone in Human and Equine Urine by Means of LC-MS/MS
33 download 

M. THEVIS, W. SCHÄNZER:
Effect of the Location of Hydrogen Abstraction on the Fragmentation of Diuretics in Negative Electrospray Ionization Mass Spectrometry
43 download 

S.A. APPOLONOVA, A.V. SHPAK, V.F. SIZOI, V.A. SEMENOV:
The Investigation of Metabolism of Mesocarb by LC/MSD Trap in Human Urine
45 download 

W. VAN THUYNE, F.T. DELBEKE:
Nutritional Supplements and Doping: The Ghent Experience
57 download 

M.K. PARR, H. GEYER, G. SIGMUND, K. KÖHLER, W. SCHÄNZER:
Screening of Nutritional Supplements for Stimulants and other Drugs
67 download 

H. GEYER, M. BREDEHÖFT, U. MARECK, M.K. PARR, U. REINHART, W. SCHÄNZER:
Oxandrolone and High Doses of Metandienone Found in Nutritional Supplements
77 download 

M. MACHNIK, M. DÜE, M.K. PARR, W. SCHÄNZER:
Anabolic Steroids in Plant Medicines for Horses
85 download  

U. MARECK, G. SIGMUND, G. OPFERMANN, H. GEYER, W. SCHÄNZER:
Identification of Non-steroidal Aromatase Inhibitors in Doping Analysis
91 download 

SHEN LI, CUI KAIRONG,WUMOUTIAN:
Screening and Confirmatory Analysis of Fenoterol, Bambuterol and its Metabolites in Human Urine by GC-MS
101 download  

U. MARECK, A. KRESS, U.W. SCHWARZ, H. GEYER, W. SCHÄNZER:
Feasibility Study on Commercially Available THC Drug Screen Test Devices
109 download 

R. GUTIERREZ GALLEGO, J. SEGURA: MALDI TOF
Mass Spectrometry Screening for the Presence of Plasma Volume Expanders in Urine
119 download 

M. THEVIS, G. OPFERMANN, W. SCHÄNZER:
LC-ESI-MS/MS Screening and Confirmation Methods for ß2-Agonists inHuman or Equine Urine
129 download 

R. VENTURA, M. VENTURA GARCÍA, R. BOQUÉ, A. MAROTO, J. RIU:
Estimating Uncertainties of Analytical Results Using Information of Internal Quality Control, Intercomparison Exercises and Reference Materials
131 download 

R. KAZLAUSKAS, D. COWAN:
WAADS QA Programme 2002
141 download 

P. VAN EENOO, F.T DELBEKE:
Chromatographic and Mass Spectrometric Criteria in Doping and Related Areas
149 download 

A. LEINONEN, T. KUURANNE, T. KOTIAHO, R. KOSTIAINEN:
Screening of Unconjugated Anabolic Steroids in Urine by Liquid Chromatography / Mass Spectrometry
161 download 

T. KUURANNE, M. KURKELA, M. THEVIS, W. SCHÄNZER, M. FINEL, R. KOSTIAINEN:
Structure-Function Relationships in the Glucuronidation of Anabolic Androgenic Steroids by Recombinant Human UDP-Glucuronosyltransferases
163 download 

A. KICMAN:
Nandrolone Progress Report to the UK Sports Council from the Expert Committee on Nandrolone
167 download 

C. VON KUK, U. FLENKER, W. SCHÄNZER:
Urinary Steroid Sulphates: Sample Preparation, Reference Values and Investigations in Biosynthesis and Metabolism
169 download 

U. FLENKER, W. SCHÄNZER:
Expression of Differences in Isotopic Composition
179 download 

A. CAWLEY, J. ROGERSON, K. RAHMAN, G.J. TROUT, R. KAZLAUSKAS:
Preliminary Results on the Carbon Isotope Ratios of Ketonic Steroids in Urine Samples Collected from Different Countries
183 download 

WANG JINGZHU, WUMOUTIAN, ZHANGYINONG, LIU XIN, YANG ZHIYONG:
Androsterone, 5a-Androstandiol and Testosterone for GC/C/IRMS – Discussion with Case Analysis
195 download 

P. PLATEN, S. SCHMIDT:
Physiology of Ghrelin and Possible Use of Ghrelin as a Doping Agent
207 download 

M. THEVIS, R.R. OGORZALEK LOO, J.A. LOO, W. SCHÄNZER:
Doping Control Analysis of Bovine Hemoglobin-based Oxygen Therapeutics in Human Plasma by LC-ESI-MS/MS
217 download 

M. THEVIS, R.R. OGORZALEK LOO, J.A. LOO, M. BRYER-ASH, W. SCHÄNZER:
Mass Spectrometric Identification of Synthetic Insulins
227 download 

C. AYOTTE:
Litigation and Doping Controls: Defending Positive Findings of Endogenous Steroids
239 download 

A. KAZLAUSKAS, K. CRAWFORD:
Understanding International Scientific Expert Work
247 download  

POSTER PRESENTATION
H.M.G. PEREIRA, M.A.S. MARQUES, I.B. TALHAS, F.R. DE AQUINO NETO: Analysis of Androgenic Steroids, b2-Agonists and Other Substances by GC-MS-ITD
259 download 

F.M.A. PEREIRA, M.A.S. MARQUES, M.C. DE OLIVEIRA, A. DOS SANTOS PEREIRA, F.R. DE AQUINO NETO:
Determination of Urinary Androgenic Glucuronides by Gas Chromatography-Mass Spectrometry
265 download 

T. HUYNH, G.J. TROUT, R. KAZLAUSKAS:
The Detection of Low Level Anabolic Agents in Bovine and Human Urine Using LC-ESI-MS-MS
271 download 

M.A.S. MARQUES, H. GEYER, W. SCHÄNZER, G. OPFERMANN, H.M.G. PEREIRA, F.R. DE AQUINO NETO:
Oxandrolone: Its Reaction with Methanol during Storage: Metabolites and Artifact Formation due to the Incorporation of an Ethylmercapto Group into Persilylated Oxandrolones
277 download 

I. BASTOS TALHAS, M.A.S. MARQUES, H.M.G. PEREIRA, F.R. DE AQUINO NETO:
Analysis of Tetrahydroisoquinoline b2-Agonists by GC-MS-ITD
283 download 

C. SCHWEIZER, P. MANGIN, M. SAUGY:
High Amount of Salbutamol: A Case Report
289 download 

D. KWIATKOWSKA, K. CHROSTOWSKI, A. POKRYWKA, E. PARTYKA, B. WÓJCIKOWSKA-WÓJCIK, E. TUREK-LEPA, D. STANCZYK, D. MICHALAK, R. GRUCZA:
The Influence of Physical Exercise on Excretion of 19-Norandrosterone in Bodybuilders’ Urine.
295 download 

M. THEVIS, G. SIGMUND, W. SCHÄNZER:
Confirmation of Ephedrines – Comparison between GC-MS and LC-MS/MS
303 download 

H.S. LUND, K. JÓNSDÓTTÍR, J.O. KULLERUD, S. AASEN, M. SANDELL, P. HEMMERSBACH, E. HAUG:
Excretion Studies with Hydroxyethyl Starch
309 download

XU YOU-XUAN, ZHANG JIAN-LI, QIN YANG, LIU XIN, WU MOUTIAN:
Identification of the Metabolites of Salmeterol in Urine of Mice by LC/MS/MS and GC/MS
315 download 

S. GUDDAT, M. THEVIS, W. SCHÄNZER:
The Diuretic Mannitol – A Problem in Doping Analysis
323 download 

C. D´ANGELO, G. CABALLERO, O. TEME CENTURIÓN, G. CASES, C. OCHOA, M. FRAGUÍO, E. CECCARELLI, M. TOTOLO, G. ZACCARO, E. ZADORECKI:
Confirmation of 11-Nor-D9-tetrahydrocannabinol-9-carboxylic Acid in Urine by Ion Trap GC-MS/MS
329 download 

D. MARTINEZ, A. ALVAREZ, M.T. CORREA, A. RODRIGUEZ, X. DE LA TORRE, R. DE LA TORRE :
Endogenous Steroids Profiles Preliminary Evaluation for a Cuban Athletes Population
335 download 

LIU XIN, ZHANGYINONG, WANG JINGZHU, YANG ZHIYONG, WU MOUTIAN:
Endogenous Steroid Profiles of Urine Samples Obtained from the 10th Chinese National Winter Games
341 download 

A.T. KICMAN, J.K. FALLON, D.A. COWAN, C. WALKER, S. EASMON, D. MACKINTOSH:
Candida albicans in Urine can Produce Testosterone: Impact on the Testosteron/Epitestosterone Sports Drug Test
349 download 

YANG SHENG, WUMOUTIAN, XIEMINHAO, DENG JING, YANG ZHIYONG, FANG ZILONG, GUO JIANJUN, ZHANG CHANGJIU:
Statistical Results of Routine Blood Test for Five Parameters Related to Sydney On-Model
355 download 

B. BIALAS, W. SCHÄNZER:
Validation of EPO Prescan Parameters - Hct, Hb, %Reti - The Influence of Physical long-term Exercise, Long Distance Flying and the Diurnal and Annual Variation of these Parameters
365 download 

T. GEISENDORFER, G. GMEINER:
Analysis of Nutritional Supplements Using Gel-Permeation as a Clean Up Step
373 download 

L.M.P. DAMASCENO, R.M.A. BENTO, L.N.L.F. GOMES, M.A.S. MARQUES, S.B. RAMOS, A.N.B. SOUZA, F.R. AQUINO NETO:
Doping Control During the VII South American Games in Brazil
377 download 

S.W. WESTWOOD, S.R. DAVIES, G.J. TARRANT:
Preparation of Certified Reference Materials for Use in Doping Analysis for Steroid Prohormones and 19-Nor Steroids
383 download  

____________________________________________________________

Manfred Donike Workshop - Proceedings of the 20th Cologne Workshop on Dope Analysis 2002
In: W Schänzer, H Geyer, A Gotzmann, U Mareck (eds.) Recent Advances In Doping Analysis (10). Sport und Buch Strauß - Köln 2002

TABLE OF CONTENT

LECTURES

C. AYOTTE, C. GUAY, M. CLÉROUX, D. GOUDREAULT, A. FAKIRIAN:
The Origin of Elevated Levels of Norandrosterone in Human Urine: Half-truths vs Facts
13 download

S. JÅTHUN, H. S. LUND, P. FEDORCSÀK, R. STORENG, P. TORJESEN, P. HEMMERSBACH:
Synthesis of Nandrolone in the Human Ovary
23 download 

U. MARECK-ENGELKE, G. SIGMUND, G. OPFERMANN, H. GEYER, W. SCHÄNZER:
Identification of the Aromatase Inhibitor Aminoglutethimide in Doping Analysis
35 download 

T. BASSINDALE, D.A. COWAN, S. DALE, A.J. HUTT, A.T. KICMAN:
Disposition of Androstenedione and Testosterone Following Oral Administration of Androstenedione to Healthy Female Volunteers; Influence on the Urinary T/E Ratio
51 download 

P. VAN EENOO, F.T. DELBEKE, N. DESMET:
Exretion Studies with a Supplement Containing 1(5a)-Androstene-3ß,17ß–diol
61 download 

V.P. URALETS, P.A. GILLETTE:
5a-Androstan-3,17b-diol and 1,4-Androstadien-3,17-dione, New Anabolic Steroids Available on the InterNet as Nutritional Supplements. Metabolism and Detection in Urine
73 download 

H. GEYER, M.K. PARR, U. REINHART, Y. SCHRADER, U. MARECK-ENGELKE, W. SCHÄNZER:
Analysis of Non-Hormonal Nutritional Supplements for Anabolic Androgenic Steroids – an International Study
83 download 

M.K. PARR, H. GEYER, U. REINHART, W. SCHÄNZER:
Approaches towards an Improved Analysis of Nutritional Supplements for Anabolic Androgenic Steroids
87 download

M. THEVIS, G. OPFERMANN, W. SCHÄNZER:
Mass Spectrometric Behaviour of Diuretics after Electrospray Ionisation and Collision-induced Dissociation
97 download 

T. KUURANNE, A. LEINONEN, K. KUOPPASALMI, S. PEDERSEN-BJERGAARD, K. RASMUSSEN, T. KOTIAHO, R. KOSTIAINEN:
Liquid-phase Microextraction (LPME) as a Sample Purification Method in LC-MS/MS Analysis of Anabolic Steroid Glucuronides
105 download

L. AMENDOLA, C. COLAMONICI, F. GARRIBBA, F. BOTRÈ:
Microwave-assisted Derivatization: Application to the Analysis of Diuretics and Corticosteroids
109 download 

R. KAZLAUSKAS, D. COWAN:
WAADS QA Programme 2001/2002
117 download 

R. VENTURA, C. JIMÉNEZ, J. SEGURA, R. DE LA TORRE AND THE MEMBERS OF THE CONSORTIUM OF ALADIN 2002: R. DE LA TORRE, R. VENTURA, W.SCHÄNZER, D. COWAN, P. HEMMERSBACH, J. WILLIAMS, R. KAZLAUSKAS, D. CATLIN:
Stability Studies of Selected Doping Agents in Urine Samples (I): Caffeine and Ephedrine Derivatives
125 download 

J.A. PASCUAL, F. LASNE, C. HOWE, M. SAUGY, P. HEMMERSBACH, V. BELALCAZAR, L. MARTIN, J. GRAINGER Y. PFISTER, P. MANGIN, G. NISSEN-LIE, V. SKIBELI:
Project for Inter-Laboratory Comparison of the Method for the Detection of rhEPO in Human Urine. Results, Conclusions and Current Status
135 download 

G. NISSEN-LIE, P. HEMMERSBACH, E. HAUG E, G. TJØNNFJORD, P. TORJESEN, V. SKIBELI:
Charge Analyses of Human Erythropoietin and Analogues
147 download 

N. ROBINSON, Y. PFISTER, P. MANGIN, M. SAUGY:
One Year’s Experiment with the Blood Screening Test to Fight against rhEPO Doping.
159 download 

C. ALMA, G.J. TROUT:
Detection of Haemoglobin Based Oxygen Carriers
169 download 

A. GOTZMANN, S. VOSS, M. MACHNIK, W. SCHÄNZER:
Detection of Hemopure® and Hemoglobin in Human Plasma by HPLC/UV and Different Types of Columns – an Approach to Screen for this Substance in Doping Analysis
179 download 

M. THEVIS, S. GUDDAT, W. SCHÄNZER: Determination of HES, Dextran and Mannitol in Human Urine
189 download 

POSTER PRESENTATION

A. KRESS, MARECK-ENGELKE, U., GEYER, H., W. SCHÄNZER:
Alternative Bulk Materials to XAD-2 (Serdolit® AD-II, Serva)
205 download 

C. VON KUK, W. SCHÄNZER:
Estrogens as Additional Parameters of Steroidprofile in Doping Analysis
211 download 

C. R. CARDOSO, M. A. S. MARQUES, I. B. TALHAS, R. C. CAMINHA, F. R. AQUINO NETO:
Determination of Oxymetholone in Human Plasma and Saliva by High Resolution Gas Chromatography -Mass Spectrometry
217 download 

D. LONGO, C. COLAMONICI, F. MOLAIONI, F. BOTRÈ:
Synephrine (Oxedrine): Analytical and Pharmacological Issues
223 download 

S. KERKENI, S. BOUABDALLAH, H. TRABELSI, K. BOUZOUITA:
Brief Report on the Doping Control during the XIVèmes Mediterranean Games in Tunis from 2nd to 15th of September 2001
229 download

A. WINGENDER, G. SIGMUND, W. SCHÄNZER:
Local Anaesthetics in Sport
235 download 

S.-H. PENG, C. DE BOLÒS, J. SEGURA, J.A. PASCUAL:
Capillary Electrophoresis Behaviour of Recombinant Human Erythropoietin
241 download 

G. NISSEN-LIE, K. BIRKELAND, P. HEMMERSBACH, E. HAUG, V. SKIBELI:
Urinary Charge Patterns of Recombinant Human Erythropoietin during Controlled Administration in Athletes
245 download 

J.GRINYER, B. HERBERT, N. PACKER, C. HOWE AND, G.J. TROUT:
Development of an Immobilised pH Gradient Gel for the EPO Urine Test
249 download

P. J. VAN DER MERWE, E. GROBBELAAR, D. YEOWART:
Stability of 19-Norandrosterone and 19-Noretiocholanolone Glucuronide in Urine under Various Storage Conditions
253 download 

G.J. TROUT , S. SOO, K. KELLY:
Longitudinal Variability of T/E Ratios in Australian Athletes
261 download 

G. E. VÂJIALA, M. LAMOR, R. SUBASU:
The Tracing Out of the Contamination with Doping Agents of the Nutritional Supplements
267 download 

K. AARSKOG, H. S. LUND, C. HELLE, P. HEMMERSBACH:
Nutritional Supplements – A Risk Assessment
273 download 

H. M. G. PEREIRA, M. A. S. MARQUES, F. R. AQUINO NETO:
Initial Study of Incidental Contamination of Clostebol in Athletes by Sexual Intercourse
279 download  

____________________________________________________________________

Manfred Donike Workshop -  Proceedings of the 19th Cologne Workshop on Dope Analysis 2001
In: W Schänzer, H Geyer, A Gotzmann, U Mareck-Engelke (eds.) Recent Advances In Doping Analysis (9). Sport und Buch Strauß - Köln 2001

TABLE OF CONTENT

LECTURES

M.THEVIS, G.OPFERMANN, W.SCHÄNZER:
Screening and Confirmation Methods for the Detection of Plasma Volume Expanders in Human Urine
13 download

D. DE BOER, H. VENEMA, A. CASTAÑERA AJENJO, L.J.A.L.DOS REYS, R.A.A. MAES:
Profiling Cannabinoids; the Significance of the Detection of 11-Nor-D9-Tetrahydrocannabivarin-9-carboxylic Acid
19 download 

M.K. HENZE, H. SPAHN-LANGGUTH, W. SCHÄNZER:
Reactions of Salbutamol and Reproterol with Urine Matrix Components - Preliminary Results
29 download 

M. THEVIS, W. SCHÄNZER:
High Speed Determination of ß-Blockers in Human Urine by LC/MS/MS
35 download 

G. GMEINER, T. GEISENDORFER, J. KAINZBAUER, M. NIKOLAJEVIC:
Quantification of Ephedrines in Urine without Sample Preparation
43 download 

U. MARECK-ENGELKE, G. SIGMUND, G.OPFERMANN,H. GEYER, W. SCHÄNZER:
Screening for Tamoxifen, Clomiphene and Cyclofenil in Doping Analysis
53 download 

H. GEYER, U. MARECK-ENGELKE, A. WAGNER, W. SCHÄNZER:
The Analysis of “Non-Hormonal” Nutritional Supplements for Prohormones
63 download 

D. GOUDREAULT, P. BHÉRER, J.-F. LÉVESQUE, D. POIRIER, C. AYOTTE:
Androstenedione Metabolism: End of the Story …
73 download 

V.P. URALETS , P.A. GILLETTE:
Individual Variations of Urinary Steroid Profiles in Glucuronide and Sulfate Fractions after DHEA Oral Administration
85 download 

P. VAN EENOO, F.T. DELBEKE, N. DESMET, P. DE BACKER:
Excretion Studies with 7-Keto-Dehydroepiandrosterone
91 download 

J. MARCOS, J.A. PASCUAL, X. DE LA TORRE, J. SEGURA:
Fast and Comprehensive Screening of Anabolic Agents and other Compounds in Human Urine by GC/MS/MS
99 download 

M.THEVIS, G.OPFERMANN, W.SCHÄNZER:
Synthesis and GC/MS-Characterization of Glucuronide Conjugates of Anabolic Steroids (2)
107 download 

V. P. URALETS, P.A. GILLETTE:
Enhanced Steroid Screening achieved by fast GC/MS with Hydrogen Carrier Gas
115 download 

M. MACHNIK, Y. SCHRADER, W. SCHÄNZER:
Plasma Levels of 19-Norsteroids after Oral and Buccal Administration of Norandrostenedione
125 download 

C. AYOTTE, D. GOUDREAULT, A. LAJEUNESSE, M. CLÉROUX, Y.RICHARD, A. CHARLEBOIS, J.-P. COUTURE, A. FAKIRIAN:
GC/C/IRMS and GC/MS in “Natural” Steroids Testing
133 download 

M. UEKI, Y. TAKAO, M. OKANO, A. IKEKITA, M. SATO:
Differentiation of Endogenous and Exogenous Steroids in Urine by Means of Isotope Ratio Mass Spectrometry
145 download 

C. WA, M. WU, Y. ZHANG, X. LIU, C. ZHANG:
Distinguish Endogenous and Exogenous Epitestosterone Using GC/C/IRMS with TLC Purification
155 download

R. KAZLAUSKAS:
Sydney Olympics 2000: An Overview
167 download 

U. FLENKER, W. SCHÄNZER:
Kinetic Isotope Effects during Metabolism of D4-Steroids
179 download 

U. FLENKER, W. SCHÄNZER:
13C/12C- Ratios in Caffeine from Different Sources and in Urinary Excreted Caffeine
187 download 

G.J. TROUT, K.R. EMSLIE, C. HOWE, R. KAZLAUSKAS, F. LASNE:
An Overview of Testing for EPO at the Sydney 2000 Olympic Games and Beyond
191 download 

POSTER PRESENTATION

H. M. G. PEREIRA. M. A. S. MARQUES, J. N. CARDOSO, F. R. AQUINO NETO:
Derivatization Study on Endogenous and Synthetic Corticosteroids by Gas Chromatography Mass Spectrometry
203 download 

B. YAP, R. KAZLAUSKAS:
Rapid HPLC Screening of Chlorothiazide, Torasemide, Xipamide and Benzthiazide in the Sydney 2000 Olympic Games
209 download 

H. TRABELSI, I. TRABELSI, F. RAOUAFI, K. BOUZOUITA:

Simultaneous Determination of Ephedrines in Urine by RP-HPLC
215 download 

F. BOTRÈ, M. MAZZARINO, E. PODESTÀ, F. ROSSI, F. MAZZEI:
Is there a Place for Electroanalysis in the Antidoping Laboratory?
223 download

A.T. CAWLEY, G.J. TROUT, R. KAZLAUSKAS:
Quantitation of Urinary Caffeine by GC/MS using 13C Caffeine as Internal Standard
229 download 

G. VAJIALA, M. LAMOR, B. CHITIMIA:
Benzbromarone, a Possible Masking Agent of Anabolic Androgenic Steroids (2)
233 download 

C. MANZONI, D. DE BOER, M. CALÇADA, I. PÓVOA, C. MARTINS, L.J.A.L.DOS REYS:
Some Analytical Data Relevant for the Detection of 1-Benzylpiperazine, a Pharmacological Alternative for Amphetamine
239 download 

H.BAÉZ, C. CAMARGO, H. OSORIO:
Simultaneous Determination and Quantitation of Cocaine Metabolites in Urine by GC/MS. Could Possibly Some of Them Be Used as New Reliable Markers of Cocaine Ingestion in Addition to Benzoylecgonine ?
245 download 

L.M.P. DAMASCENO, R.M.A. BENTO, L.N.L.F. GOMES, R. DE LA TORRE, F.R. AQUINO NETO:
Mesocarb Analysis Revisited
253 download 

G. SIGMUND, , G. OPFERMANN, I. SEINSCH, W. SCHÄNZER:
Detection of Bupropion and Metabolites
259 download 

F. BOTRÈ, L. AMENDOLA, M. MAZZARINO, F. MOLAIONI, B. NERI, F. ROSSI, G. DE FEO:
One Year of Nandrolone at the Antidoping Laboratory of Rome
265 download 

M. MAZZARINO, F. BOTRÈ, F. ROSSI, E.PAONE, J. PECORI-GIRALDI:
Lack of Increased Diuresis after Topical Administration of the Carbonic Anhydrase Inhibitor Dorzolamide
269 download 

S. WESTWOOD, D. HANCOCK, B. KING, H. WANG, J. MAKRYNIKOLAS, S. STARLING:
Stability Trials of Anabolic Steroid Reference Materials
275 download 

Y. XU, Y. QIN, S. PENG:
Observation of Degradation of Some Doping Agents in Plasma
281 download 

E. SETIAWATI, F.D. SUYATNA, M.S. WIRIA, D. ULAMSARI:
Profile of Urinary Excretion in Indonesian Volunteers after DHEA Administration
287 download 

R.M.A. BENTO, L.M.P. DAMASCENO, H.M.G. PEREIRA, L.N.L.F. GOMES, J.N. CARDOSO, F.R. DE AQUINO NETO:
Evaluation of Some Energetic and Nutritional Supplements in Brazil: Can They Originate a Positive Case for Stimulants in Doping Control?
293 download 

M.S. HIFNAWY, S.M. AZZAM, S.N. SOLIMAN, I.B. SHAHEED, S.M. ABDEL LATIF:
Egyptian Desert Truffles, Androgenic Natural Product, Possibility of Abusing in Sport
299 download 

C.P. D´ANGELO, G.M. CABALLERO, O. TEME CENTURIÓN, C. DI NARDO, G.G. CASES, C.F. OCHOA, L. CHINCHILLA, E. CECCARELLI, M. E. ZADORECKI, G. ZÁCCARO, M. SOL FRAGUÍO:
Steroidprofile and Peptides Hormones in Urine of Argentine Athletes
305 download 

B. BIALAS, D. SCHWENKE, W. SCHÄNZER, R.K. MÜLLER:
Diurnal Variation of Indirect Parameters for the Detection of Recombinant Human Erythropoietin Abuse in Athletes
311 download 

M. WU, X. LIU, S. WANG, L. SHEN:
Detection of LH (luteinizing hormone) in Sport - One Year Statistics
317 download 

C. FOURACRE, R. KAZLAUSKAS:
Diuretics Screening and Confirmation Using LC/MS/MS
321 download  

________________________________________________________________

Manfred Donike Workshop -  Proceedings of the 18th Cologne Workshop on Dope Analysis 2000
In: W Schänzer, H Geyer, A Gotzmann, U Mareck-Engelke  (eds.) Recent Advances In Doping Analysis (8). Sport und Buch Strauß - Köln 2000  

TABLE OF CONTENT

I NUTRITIONAL SUPPLEMENTS

P.VAN EENOO, F.T.DELBEKE, N.DESMET, P.DE BACKER:
Excretion Studies with Tribulus Terrestris
13 download

H.GEYER, U.MARECK-ENGELKE, W.SCHÄNZER:
The Analysis of Nutritional Supplements for Anabolic – Androgenic Steroids
23 download 

A.GOTZMANN, B.KOMANNS, A.ADIB, M.BREDEHÖFT, W.SCHÄNZER:
Creatine - A Doping Substance ?
33 download

II NEW ASPECTS IN DOPING ANALYSIS

M.THEVIS, G.OPFERMANN, W.SCHÄNZER:
Rapid Screening Method to Detect Hydroxyethyl Starch (HES) in Human Urine
41 download 

D.THIEME, J.GROSSE, R.LANG, R.K.MUELLER, A.WAHL:
Suitability of HPLC/MS-MS for the Detection of Diuretics
47 download 

L.DAMASCENO, R.VENTURA, J.ORTUNO, M.FARRÉ, J.CARDOSO, J.SEGURA, C.JIMÉNEZ:
Analytical Methodology for the Detection of b2-agonists in Urine by GC/MS
57 download 

M.K.HENZE, G.OPFERMANN, H.SPAHN-LANGGUTH, W.SCHÄNZER:
Screening of Beta-2-Agonists and Confirmation of Fenoterol, Reproterol, Orciprenaline and Terbutaline after Cyclisation with Formaldehyde
59 download 

U.FLENKER, V.GOUGOULIDIS, W.SCHÄNZER:
Confirmation of Doping with Synthetic Endogenous Anabolic Steroids: Validation of the Method and Concepts of Inference
69 download 

N.ROBINSON, B. MARTI, P. MANGIN, M.SAUGY:
Secondary Markers of Erythroid Activity: Any Use for Doping Diagnosis in Professional Cyclists?
79 download 

M. ZORZOLI, L. SCHATTENBERG, P. MANGIN:
The Medical Monitoring of the International Cycling Union
83 download 

III TOOLS FOR THE ANALYSIS OF ANABOLIC STEROIDS PAGE

M.THEVIS, E.NOLTEERNSTING, G.OPFERMANN, W.SCHÄNZER:
Synthesis and GC/MS-Characterization of Glucuronide Conjugates of Anabolic Steroids
89 download 

T.KUURANNE, A.LEINONEN, O.AITIO, K.KUOPPASALMI, R.KOSTIAINEN:
Enzyme-assisted Synthesis and Mass Spectrometric Behaviour of Anabolic Steroid Glucuronides
99 download 

S.WESTWOOD, D.HANCOCK, C.MOULE, B.NOBLE, S.STARLING:
Progress in the Preparation of Anabolic Steroid Reference Materials & Certified Reference Materials
109 download 

V.P.URALETS, P.A.GILETTE:
Some Useful Applications of Helix Pomatia Juice in Anabolic Steroid Testing. Essential Metabolites of Sulfate Fraction.
119 download 

D.H.VAN DE KERKHOF, J.W.ZWIKKER, V.E.M.KAATS-RICHTERS, K.BOUWMAN, R.D.VAN OOIJEN, D.DE BOER, R.A.A.MAES:
Trimethylsilylation of 3-Keto-D4-ene Steroids: Thermodynamic Versus Kinetic Control of Enolization
129 download 

IV DETECTION OF 19-NORANDROSTERONE

P.HEMMERSBACH, A.H.HÅGENSEN, J.MISUND:
Determination of Urinary Norandrosterone Excretion in Females during one Menstrual Cycle by Gas Chromatography / Mass Spectrometry
141 download 

U.MARECK-ENGELKE, G.SCHULTZE, H.GEYER, W.SCHÄNZER:
19-Norandrosterone in Pregnant Women
145 download 

W.SCHÄNZER, A.BREIDBACH, H.GEYER, C.V.KUK, E.NOLTEERNSTING, M.THEVIS:
Metabolism of Nortestosterone, Norandrostenedione and Norandrostenediol: Identification of 3a-hydroxyestr-4-en-17-one glucuronide and 3a,16a-dihydroxy-5a-estran-17-one glucuronide and sulphate
155 download 

V POSTER PRESENTATION

D.MIRSON, A.RIDOLFI, P.QUIROGA, G.PASCUALI, H.GONZALEZ, C.LÓPEZ, E.VILLAAMIL, O.ROSES:
Urinary Excretion of Cocaine, Ecgonine Methyl Ester and Benzoylecgonine Following Ingestion of Coca Leaves Decoction
175 download 

R.VENTURA, L.DAMASCENO, J.CARDOSO, J.SEGURA:
Confirmation b-Agonists in Urine by GC/MS Using the Diagnostic Evidence of two Consecutive Derivatization Procedures
183 download 

N.HALATCHEVA, E.DANEVA: Some Aspects of Investigation of Extraction, Derivatisation and Excretion of Terbutaline and Salbutamol
189 download 

D.KAROVA, M.ANGUELOVA, N.HALATCHEVA:
Amiloride - Detection and Excretion Study under Condition of Steroid Screening Procedure
197 download 

I.BAILLOUX, S.DE BARROS, A.LAHAUSSOIS, J.-C.MATHURIN, J.DE CEAURRIZ:
LC-MS and LC-MS/MS in Doping Control Analysis of Synthetic Glucocorticoids
203 download 

M.FERRY, J.-C.MATHURIN, M.BECCHI, J.DE CEAURRIZ:
Influence of Pregnenolone Administration on IRMS Analysis
209 download 

G.VAJIALA, R.MIHAILESCU, M.LAMOR:
Benzbromarone - A Possible Masking Agent of Androgen Anabolic Steroids; Identification by GC/MS and its Action upon the Steroid Profile (1)
215 download 

C.D’ANGELO, L.MBARAK, G.CASES, E.CECCARELLI, L.CHINCHILLA, C.DI NARDO, L.IGLESIAS, C.OCHOA, O.TEME CENTURIÓN, E.ZADORECKI, G.CABALLERO: Quantification of Epitestosterone and Testosterone in Urine by Gas Chromatography-Mass Spectrometry
221 download 

J.GROSSE, R.LANG, R.K.MUELLER, D.THIEME, A.WAHL:
Appearance of an Oxabolone Metabolite after Administration of OTC 19-Norsteroids - Metabolite or Artefact ?
227 download 

C.RODRÍGUEZ, J.MUNOZ-GUERRA, M.PLATA, C.FERNÁNDEZ, A.F.RODRÍGUEZ, D.CARRERAS:
Statistical Analysis Relating to Detection of 19-Norandrosterone in 17283 Samples analysed in the Doping Control Laboratory of Madrid during 1998 and 1999
233 download 

C.RODRÍGUEZ, J.MUNOZ-GUERRA, M.PLATA, C.FERNÁNDEZ, A.F.RODRÍGUEZ, D.CARRERAS:
Antidoping Testing at the VII IAAF World Championships in Athletics, 21-29 August 1999 Sevilla (Spain)
239 download

P.J.VAN DER MERWE, H.S.L.KRUGER, J.W.PIETERSE, M.J.PRETORIUS, N.J.DE KOCK:
Report on the Doping Control during the 7th All Africa Games in South Africa
245 download  

___________________________________________________________

Manfred Donike Workshop -  Proceedings of the 17th Cologne Workshop on Dope Analysis 1999
In: W Schänzer, H Geyer, A Gotzmann, U Mareck-Engelke  (eds.) Recent Advances In Doping Analysis (7). Sport und Buch Strauß - Köln 1999 

TABLE OF CONTENT

I NEW ASPECTS IN DOPING ANALYSIS

R.K. MUELLER, J. GROSSE, D. THIEME, R. PREISS:
Banned Agents and Related Compounds - How many ?
13 download

J.-C. MATHURIN, J. DE CEAURRIZ, M.-T. SICART, B. MARION, M. AUDRAN, M.-P. KRAFFT:
Development of an Analytical Strategy for Detection of Perfluorocarbons (PFCs) for Anti-Doping Control: Analysis of Breath and Blood Samples after i.v. Injection of a PFC’s Emulsion in Rats
21 download 

M. THEVIS, G. OPFERMANN, W. SCHÄNZER:
GC/MS-Detection of Hydroxyethyl Starch (HES) in Human Urine
31 download 

D. DE BOER, L.J.A.L.DOS REYS, I.J. BOSMAN, R.A.A. MAES:
The Detection of the Use of some Popular Hallucinogenic Compounds, including those of Psilocybe Mushrooms
41 download 

U. MARECK-ENGELKE, H. GEYER, W. SCHÄNZER:
Tetrahydrocannabinol (THC) in Dope Control
51 download 

D. GOUDREAULT, A. FAKIRIAN:
Selegiline  Urinary Metabolites
61 download 

H. GEYER, E. NOLTEERNSTING, W. SCHÄNZER:
Finasteride - A Substance for Manipulation in Dope Control ?
71 download 

R. S. BLACK, L. D. BOWERS:
A Potential Case of Fluvoxamine-Induced Inhibition of Caffeine Metabolism
81 download 

B. YAP, R. KAZLAUSKAS:
Corticosteroids and Exercise-Stress Response
85 download 

II ANABOLIC AGENTS

M. SAUGY, N. ROBINSON, C. CARDIS, C. SCHWEIZER, L. RIVIER, P. MANGIN, C. AYOTTE, J. DVORAK:
Nandrolone Metabolites in Football Players: Utility for in and out of Competition Tests
95 download 

B. LE BIZEC, I. GAUDIN, A. POHU, F. MONTEAU, F. ANDRE:
Identification of Endogenous 19-Norandrosterone in Human Urine
109 download 

V.P. URALETS, P.A. GILLETTE:
Over-the-Counter D5 Anabolic Steroids 5-Androsten-3,17-dione; 5-Androsten-3b,17b-diol; Dehydroepiandrosterone and 19-Nor-5-androsten-3,17-dione: Excretion Studies in Men
121 download 

R.K. MUELLER, R. PREISS, M. KRUEGER:
Anabolic Steroids and Enhanced Aggressiveness
131 download 

J. GROSSE, D. THIEME, R. LANG, R.K. MUELLER:
Formebolone Detection
143 download 

B. VITORIANO, D. DE BOER, C. MANZONI, A. AJENJO, L.J.A.L.DOS REYS:
Preliminary Results of the Implementation of some Metabolites of the Anabolic Androgenic Testolactone in the Screening Procedures
153 download 

D.H. VAN DE KERKHOF, P.M. VAN DER VOORT, D. DE BOER, R.A.A. MAES: Confirmation of Endogenous Boldenone Production: A Procedure for an in vitro Experiment
161 download 

J.-F. LEVESQUE, CH. AYOTTE:
Criteria for the Detection of Androstenedione Oral Administration
169 download 

S. WESTWOOD, B. NOBLE, C. MOULE:
Synthesis and Characterisation of Steroid Metabolites for Use as Analytical Reference Materials
181 download 

R. BERGÉS, J. SEGURA, K.D. FITCH, A.R. MORTON, X. DE LA TORRE, R. VENTURA, M. MAS, M. FARRÉ:
Discrimination of Prohibited Oral Use of Salbutamol in Sport from Authorized Inhaled Asthma Treatment: Update
193 download 

P.J. VAN DER MERWE:
The Influence of the Use of Multiple Doses of DHEA on the Steroid Profile
203 download 

J.F. LEVESQUE, C. AYOTTE:
The Oral Administration of DHEA : The Efficiency of Steroid Profiling
213 download 

III TECHNIQUES OF MS DETECTION AND SAMPLE PREPARATION

J. ROGERSON, G.J. TROUT:
GC-C-IRMS Detection of Steroid Metabolites - Some Hardware Considerations
223 download 

M. BECCHI, F. PERRET, D. FOREST, J.C. MATHURIN, J. DE CEAURRIZ:
Carbone Isotope Ratio Mass Spectrometry of Endogenous Corticosteroids
233 download 

U. FLENKER, E. NOLTEERNSTING, H. GEYER, W. SCHÄNZER:
A Screening Method for Synthetic Testosterone and its Precursors based on GC/C/IRMS
241 download 

G. TROUT, S. SOO, R. KAZLAUSKAS:
A Single Screen for Steroids using HRMS
249 download 

T. KUSAMRAN, X. DE LA TORRE, R. DE LA TORRE, B. RASMUSSEN, P. WILAIRAT, T. ANUKARAHANONTA:
Monitoring of Low Concentration Anabolic Steroids in Urine Samples from the 13th Asian Games by Ion-trap GC/MS/MS
255 download 

M. WU, Y. ZHANG, X. LIU, C. ZHANG:
CID Mass Spectrometric Characterization of some Epimeric Anabolic Androgenic Steroids
267 download 

R. KAZLAUSKAS, T. HUYNH, A. STENHOUSE, S. SOO, J. TJOA, B. YAP:
Automated Solid Phase Extraction
281 download 

IV PEPTIDE HORMONES

K.I. BIRKELAND, K. FISKUM, B. BJERKE, E. HAUG, P. HEMMERSBACH:
Physiological and non-Physiological Variations in Serum Levels of Soluble Transferrin Receptor - Implications for Use as Indicator of Doping with rhEPO
289 download 

K.R. EMSLIE, C. HOWE, G. TROUT:
Measurement of Urinary Erythropoietin Levels in Athletes
291 download 

B. BIALAS, A. BREIDBACH, W. SCHÄNZER:
Individual Reference Ranges for Serum Erythropoietin (sEPO) - Part II: Influence of Long Distance Flying
301 download 

V POSTER PRESENTATION

X. LIU, Y. ZHANG, M. WU, C. ZHANG: The Steroid Profiles after Oral Administration of Testosterone Undecanoate with Different Doses
311 download 

M.A.S. MARQUES, C.H.B. BIZARRI, J. N. CARDOSO, F.R. DE AQUINO NETO
Effect of Finasteride on the Urinary Steroid Profile: A Case Study
317 download 

T. KUURANNE, M. VAHERMO, A. LEINONEN, K. KUOPPASALMI, J. TASKINEN, E. ELOVAARA, R. KOSTIAINEN:
ESI-MS and MS/MS Detection of the Glucuronide Conjugate of 17a-methyl-5b-androstan-3a,17b-diol and its D3-labelled Analogue
323 download 

R. ARMSTRONG, S. BIDDLE, E. HOUGHTON:
Highly Specific, Low Level Detection of Stanozolol and Metabolites using Solid Phase Extraction and ELISA Technology
329 download 

M.K. HENZE, G. OPFERMANN, W. SCHÄNZER: Liquid-Liquid Extraction-pH-Profiles of Selected Beta-2-Sympathomimetic Agonists
335 download 

E. HABER, J. MUNOZ-GUERRA, C. SORIANO, D. CARRERAS, C. RODRIGUEZ, F.A. RODRIGUEZ:
Automated Preparation for Screening of Anabolic Steroids in Urine in HP 7686 PrepStationSystem
341 download 

R. GRUCZA, J. SMORAWINSKI, D. KWIATKOWSKA:
Application of Ketoconazole Test in Doubtful Doping Cases of Polish Athletes
347 download 

I. SEINSCH, C.V. KUK, M. MACHNIK, G. SIEBIG, S. HORNING, G. SIGMUND, A. BREIDBACH, W. SCHÄNZER
Detection of Nortestosterone Application in Horses. A Screening Method for Nortestosterone in Horse Serum with a Possible Confirmation in Urine
353 download 

V. CIRIMELE, P. KINTZ, A. TRACQUI, B. LUDES:
Identification of 10 Corticosteroids in Human Hair by Liquid Chromatography Ionspray Mass Spectrometry
359 download 

A. KNIEß, R.K. MÜLLER, J. KRATZSCH:
Quantitation of Human Growth Hormone, Insulin-like Growth Factors I and II (IGF-I and II) and IGF Binding Protein-2 and -3 in Athletes [„Blood Study“ of the German Antidoping Commission (ADK)]
365 download 

H. BÁEZ-G., C. CAMARGO-G.:
The Occurrence of Cocaine and Metabolites in Hair of Drug Abusers. Possible Determination of Cut-Off Values
371 download 

XU YOUXUAN, PENG SHIQI, QIN YANG, YANG SHUMIN:
Determination of Urinary Clopamide by Using LC/APCI/MS
377 download 

A. POKRYWKA, D. KWIATKOWSKA, D. STANCZYK, K. CHROSTOWSKI:
Midodrine (Gutron) Detection in Urine Samples. Should Midodrine be Added to the IOC Doping List ?
383 download 

 _____________________________________________________________

Manfred Donike Workshop -  Proceedings of the 16th Cologne Workshop on Dope Analysis 1998
In: W Schänzer, H Geyer, A Gotzmann, U Mareck-Engelke (eds.) Recent Advances In Doping Analysis (6). Sport und Buch Strauß - Köln 1999

Table of Contents

I Anabolic Agents

D. THIEME, J. GROSSE, H. SACHS, R.K. MUELLER:
Detection of Several Anabolic Steroids of Abuse in Human Hair
9 download

M. MACHNIK, H. GEYER, S. HORNING, A. BREIDBACH, P. DELAHAUT, W. SCHÄNZER:
Longterm Detection of Clenbuterol in Human Scalp Hair by Means of Gaschromatography / High Resolution Mass Sectrometry (GC/HRMS)
31 download 

W. SCHÄNZER, H. GEYER, S. HORNING:
17,17-Dimethyl-18-nor-5b-androst-1,13-dien-3a-ol (18-Normetenol) in Longterm Detection and Confirmation of Positive Metandienone Cases
37 download 

K. CHROSTOWSKI, D. KWIATKOWSKA, E. PARTYKA, B. WÓJCIKOWSKA-WÓJCIK:
Danazol Detection in Doping Analysis in Urine
53 download 

YINONG ZHANG, MOUTIAN WU, XIN LIU, CHANGJIU ZHANG:
Analysis of Urinary Metabolites of Mibolerone in Man by Gas Chromatography / Tandem Mass Spectrometry
65 download 

S. RENDIC, E. NOLTEERNSTING, W. SCHÄNZER:
Metabolism of Anabolic Steroids by Recombinant Human Cytochrome P450 Enzymes
81 download 

II Detection of 19-Norandrosterone

M. CIARDI, R. CICCOLI, M.V. BARBARULO, R. NICOLETTI:
Presence of Norandrosterone in “Normal“ Urine Samples
97 download 

P. VAN EENOO, F.T. DELBEKE, F.H. DE JONG, P. DE BACKER:
Urinary Metabolites of Endogenous Nandrolone in Women:
A Case Study
105 download 

U. MARECK-ENGELKE, H. GEYER, W.SCHÄNZER:
19-Norandrosterone - Criteria for the Decision Making Process
119 download 

N. ROBINSON, C. CARDIS, A. DIENES, C. SCHWEIZER, M. SAUGY, L. RIVIER:
Immunoaffinity Chromatography Combined with the Ion Trap Technique in order to Detect Traces of 19-Norandrosterone
131 download 

III Steroid Profiling

M. UEKI, M. OKANO, A. IKEKITA:
Nagano Strategy against Natural Hormone Doping - Testosterone, DHT, Androstenedione and DHEA -
145 download 

V.P. URALETS, P.A. GILLETTE, R.K. LATVEN:
Over-the-Counter Anabolic Steroids 4-androsten-3,17-dione; 4-Androsten-3b,17b-diol, and 19-Nor-4-androsten-3,17-dione: Excretion Studies in Men
147 download 

P. VAN EENOO, F.T. DELBEKE, N. DESMET, P. DE BACKER:
Excretion Studies with 4-androstene-3,17-dione
171 download 

M. GARLE, E. PALONEK:
Androstenedione: Excretion Studies from Single and Multiple Dose Experiments
181 download 

S.H. PENG, J. SEGURA, M. FARRÉ, J.C. GONZÁLEZ, X. DE LA TORRE:
Overall Biological Markers of Oral Testosterone Undecanoate Misuse
185 download 

C. SCHWEIZER, C. CARDIS, M. CAUDERAY, L. RIVIER, M. SAUGY:
Profile Variations through Puberty in Young Adolescent Girls
205 download 

R. DE LA TORRE, X. DE LA TORRE , J. SEGURA, M.T. SMEYERS, R. VENTURA, J.M. TORRES, C. ALÍA, T. BARÓ:
Urine Contamination by Micro-Organisms and Alterations in the Endogenous Steroid Profile. A Prospective Study
223 download 

R. GRUCZA, J. SMORAWINSKI, K. CHROSTOWSKI:
Ketoconazole Test - A Case Study
237 download 

IV Techniques of MS Detection

U. FLENKER, S. HORNING, E. NOLTEERNSTING, H. GEYER, W. SCHÄNZER:
Measurement of 12C/13C-Ratios to Confirm Misuse of Endogenous Steroids
243 download 

XIN LIU, MOUTIAN WU, YINONG ZHANG, CHANGJIU ZHANG:
Application of TSQ-7000 in Doping Control Analysis
257 download 

G. TROUT; J. MURBY, R. KAZLAUSKAS:
High Resolution Mass Spectrometry in the Antipodes
269 download 

S. HORNING, M. HOEHN, H. MUENSTER, H. GEYER, W. SCHAENZER:
GC/HRMS-ION TRAP Screening and Confirmation of Anabolic Steroids
277 download 

R. CICCOLI, F. ROSATI, F. ROSSI, R. NICOLETTI:
One Year Use of AUTOSPEC-TOF: Experience of Antidoping Lab in Rome
287 download 

V Peptide Hormones

A. BREIDBACH, W. SCHÄNZER:
Individual Reference Ranges for serum Erythropoietin (sEPO) - A Possible Approach to Detect Misuse
301 download 

P. HEMMERSBACH, J. STRAY-GUNDERSEN, J. HALLÉN, E. HAUG, R. BAHR, K.I. BIRKELAND:
The Effects of Supraphysiological Doses of Erythropoietin in Healthy Young Men
311 download 

V. SKIBELI, G. NISSEN-LIE, A. NOREAU, P. TORJESEN, P. HEMMERSBACH, K.I. BIRKELAND:
Immuno-Affinity Extraction of Erythropoietin from Human Serum by Magnetic Beads
313 download 

A. LEINONEN, R. TÄHTELÄ, E. KARJALAINEN:
Detection of Human Chorionic Gonadotropin in Urine by two Different Immunoassays
331 download 

VI Stimulating Substances

V.A. SEMENOV, S.L. BOLOTOV, V.F. SIZOI: New Stimulant of Russia – Carphedon
337 download 

J. GROSSE, D. THIEME, R. LANG, R.K. MUELLER:
Elucidation of Carphedon Doping - Designer Psychostimulant in Sports
349 download 

D.H. VAN DE KERKHOF, D. DE BOER, R.A.A. MAES:
The Position of the Hydroxy Group in the Main Bromantane Metabolite
361 download 

KAIRONG CUI, MOUTIAN WU, XIN LIU, YINONG ZHANG, SHAN WANG:
Study on the Metabolites of Bromantane in Urine using GC/MS and GC/Tandem MS/MS
375 download 

D. GOUDREAULT, C. AYOTTE:
The Identification of Fenozolone Urinary Metabolites *)
391 download 
*) This paper was presented during the 15th Cologne Workshop on Dope Analysis, 23rd till 28th February, 1997. As a matter of fact it was not published in the Proceedings connected to this Workshop: ‘Recent Advances in Doping Analysis (5), Köln 1998’. We apologize for this misunderstanding.
The Editors

VII New Aspects

R. BERGÉS, J. SEGURA, R. VENTURA, X. DE LA TORRE, M. MAS, M. FARRÉ, K.D. FITCH, A.R. MORTON, M. UEKI:
Oral versus Inhaled Salbutamol: Is Distinction Possible by Urine Analysis?
405 download 

H. GEYER, U. MARECK-ENGELKE, W. SCHÄNZER:
The Black Market of Anabolic Agents
421 download 

R. KAZLAUSKAS, A. LISI, G. TROUT:
Chiral Derivatisation
431 download 

K. CHROSTOWSKI, D. KWIATKOWSKA, A. POKRYWKA, K. BAL:
Aminoglutethimide Detection in Urine Samples
443 download 

P.J. VAN DER MERWE, J. PRETORIUS, E. KRUGER:
The Influence of Antimalarial Drugs on Dope Testing
455 download 

VIII Poster Presentation

N. HALATCHEVA, A. TSOUTSOULOVA-DRAGANOVA, D. CAROVA:
Analyses of Urine Samples of the First Bulgarian “Methadone Baby“
469 download 

A. TSOUTSOULOVA-DRAGANOVA, N. HALATCHEVA, V. KURTEVA, D. CAROVA, A. Andreeva, M. ANGUELOVA:
Investigations on a “Black Market’s Drug - Carphedon“
475 download 

G. SIGMUND, I. SEINSCH, W. SCHÄNZER:
Detection of Phentermine and Phentermine Derivatives as Metabolites of Oxethazine
483 download 

I. BELLAHN, E. NOLTEERNSTING, G. OPFERMANN, W. SCHÄNZER:
Preliminary Results of Excretion Studies with Salbutamol
489 download 

____________________________________________________________

Manfred Donike Workshop -  Proceedings of the 15th Cologne Workshop on Dope Analysis 1997
In: W Schänzer, H Geyer, A Gotzmann, U Mareck-Engelke  (eds.) Recent AdvancesIn Doping Analysis (5). Sport und Buch Strauß - Köln 1998  

Table of Contents

I Anabolic Agents

W. SCHÄNZER, H. GEYER, S. HORNING:
Long-term Determination of Metandienone and Mestanolone
13 download

H. SAUERWEIN, A. GLEIXNER, H.H.D. MEYER:
Clenbuterol: Longterm Detection via Hair Analysis
27 download 

D. DE BOER, K.M. HÖLD, D.J. CROUCH, D.G. WILKINS, D.E. ROLLINS, R.A.A. MAES:
The Potential Use of Hair in Doping Control in General and in the Detection of Sanozolol in Particular
41 download

A.T. KICMAN, S.B. COUTTS, D.J. HANDELSMAN, F.C.W. WU, D. A. COWAN: Adrenal Gland Contribution to Urinary Epitestosterone in Men
49 download 

II Steroid Profiling

U. MARECK-ENGELKE, H. GEYER, W. SCHÄNZER:The
 Interpretation of Female Steroid Profiles
51 download

M. UEKI, M. OKANO, A. IKEKITA, T. HIRUMA, M. SATO:
Epiandrosterone Glucuronide as a Sign to Indicate Natural Hormone Doping
71 download 

R. KAZLAUSKAS:
Effects of Dehydroepiandrosterone on Urinary Steroids
83 download 

R. GRUCZA, K. CHROSTOWSKI, D. KWIATKOWSKA, A. POKRYWKA, A. CHAJEWSKI:
Changes of Steroid Profiles in Male and Female Athletes
91 download

III Sample Preparation

H. GEYER, W. SCHÄNZER, U. MARECK-ENGELKE, E. NOLTEERNSTING, G. OPFERMANN:
Screening Procedure for Anabolic Steroids - The Control of the Hydrolysis with Deuterated Androsterone Glucuronide and Studies with Direct Hydrolysis
99 download 

R. DE LA TORRE, X. DE LA TORRE, A. ARTOLA, S. CORCIONE, S. DICENTA, J. SEGURA:
Hydrolyses Procedures in Sample Preparation. Esterase Activity Associated to Helix Pomatia Glucuronidase Preparations
103 download

M. MACHNIK, P. DELAHAUT, S. HORNING, W. SCHÄNZER:
Preparation of Immuno Affinity Columns
121 download 

G. SIGMUND, S. HORNING, I. SEINSCH, W. SCHÄNZER, M. DONIKE:
Confirmation of Clenbuterol - Sample Preparation and HRMS
129 download 

IV Techniques of MS Detection

S. HORNING, H. GEYER, A. GOTZMANN, W. SCHÄNZER:
Detection of Exogenous Steroids by 13C/12C Analysis
135 download

E. NOLTEERNSTING, W. SCHÄNZER:
Performance Test of the new Mass Selective Detector HP 5973 in Dope Analysis of Anabolic Androgenic Steroids
149 download

D. THIEME, J. GROSSE, R.K. MUELLER, A. WAHL:
Interpretation of High Resolution and Tandem MS Data: Two Relevant Cases of Anabolic Steroid Metabolites at pg Level in Blood and Urine
157 download

J. MUNOZ-GUERRA, D. CARRERAS, C. SORIANO, C. RODRÍGUEZ, A.F. RODRÍGUEZ:
Use of Ion Trap (GC-MS-MS) Mass Spectrometry for Detection and Confirmation of Anabolic Substances at Low Concentration Levels in Doping Analysis
169 download 

M.A. POPOT, P. GARCIA, Y. BONNAIRE:
Screening and Confirmation Method for the Detection of Synthetic Corticosteroids in Human Urine
185 download 

V Peptide Hormones

S. RENDIC, S. PICKETT, B. BROMLEY:
Human Recombinant Erythropoietin (rhEPO) - Physiology and Biochemistry
191 download 

A. BREIDBACH, W. SCHÄNZER:
Erythropoietin with Nichols Institute Diagnostics Chemiluminescence Immunoassay for Erythropoietin after Gelfiltration
209 download 

S.M YANG, X.B WANG, Z.L FANG, SH. WANG, Y. QIN, M.Q YI, H. GAO, B.H XU, L. ZHOU, F.X ZENG, J.J GUO, ZH. Y YANG, J. DENG, M.H XI, Z.Y YANG, CH.J ZHANG:
Observation on Hematology and Biochemistry of Six Chinese Following rhEPO Administration
215 download 

K. CHROSTOWSKI, R. GRUCZA:
Diagnostic Validity of HDL-C, CK and LH Measured in Blood Serum for Discrimination of AAS Users during ‘on’ and ‘off’ Cycle in Body Builders
223 download 

VI Stimulating Substances

A. TSOUTSOULOVA-DRAGANOVA, N. HALATCHEVA, D. KAROVA:
Metabolism of Benzphetamine and Clobenzorex in Human Urine
231 download 

D. DE BOER, M.L.D. DE GRAAF, P. GORTER, R.A.A. MAES:
The Implementation of the Detection of the Abuse of 3,4-methylenedioxymethamphetamine and Analogues in Doping Control Screening Procedures
249 download 

W. SCHÄNZER, A. GOTZMANN:
The Cologne Protocol to Follow-up Positive Caffeine Cases
259 download 

C. SCHWEIZER, C. CARDIS, M. SAUY, L. RIVIER:
Nicotine in Sport: Use or Abuse
269 download 

M. UEKI, A. IKEKITA, M. OKANO, T. HIRUMA:
Bromantan: - Japanese Experience -
279 download 

V.F. SIZOI, S.L. BOLOTOV, V.A. SEMENOV:
Study of Bromantan Metabolites Structure
287 download 

VII New Aspects

H.GEYER, P. BERSCHICK, U. MARECK-ENGELKE, W. SCHÄNZER:
DNA Typing for the Confirmation of Manipulation in Dope Control: A Casework
301 download 

M.I. MAGUREGUI, M.B. BARROSO, R.M. ALONSO, R.M. JIMENEZ:
Capillary Electrophoresis (CE) for the Screening and Quantitative Determination of some Diuretics and b-blockers
303 download 

W. SCHÄNZER, G. SIGMUND:
Excretion Studies with Dextropropoxyphene
305 download 

XU YOUXUAN, WU MOUTIAN, SHEN LI, WU YUN, WANG SHAN, CUI KAIRONG, ZHANG CHANGJIU:
Studies on the Analysis of Dextropropoxyphene and its Metabolite in Human Urine
311 download 

V.P. URALETS, P.A. GILLETTE, R.K. LATVEN:
Fruitful Application of Steroid Methodology for Drug of Abuse Testing: Comprehensive Benzodiazepine Screening and Confirmation
317 download 

S.Horning, W.Schänzer, B.Sample:
HRMS Analyes Performed at the 1996 Summer Olympic Games
329 download  

____________________________________________________________

Manfred Donike Workshop -  Proceedings of the 14th Cologne Workshop on Dope Analysis 1996
In: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck-Engelke (eds.) Recent Advances 
In Doping Analysis (4). Sport und Buch Strauß - Köln 1997  

Table of Contents

Obituary: Prof. Dr. rer. nat. Manfred Donike

I Biochemical Aspects of Steroid Hormones

V. ROGOZKIN, B. FELDKOREN:
Feasible Mechanism of the Testosterone Anabolic Action
13 download

S. RENDIC:
Drug Interactions in Biosynthesis and Metabolism of Steroid Hormones: The Role of Human Cytochrome P450s
21 download 

II Anabolic Androgenic Steroids

W. SCHÄNZER, S. HORNING, G. OPFERMANN, M. DONIKE:
Gas Chromatography/Mass Spectrometry Identification of Long-term Excreted Metabolites of the Anabolic Steroid 4-Chloro-1,2-dehydro-17a-methyltestosterone in Humans
33 download 

V.P. URALETS, P.A. GILLETTE, R.K. LATVEN:
Occurrence of 19-Nordehydro-Androsterone/Etiocholanolone in Nandrolone Positive Specimens
35 download

D. THIEME, J. GROSSE, R.K. MUELLER:
Observations on new Metabolites of Clostebol by High-Resolution-MS
43 download 

III Steroid Profile

X. DE LA TORRE, J.A. PASCUAL, J. ORTUNO, J. SEGURA:
Steroid Profile and Sports - A Cluster Analysis of Samples from Barcelona '92 Olympic Games
59 download 

X. DE LA TORRE, J. SEGURA, Z. YANG, Y. LI, M. WU:
Testosterone Detection in Different Ethnic Groups
71 download 

C. AYOTTE, A. CHARLEBOIS:
T/E Values: Measurements and Observations
91 download 

P. HEMMERSBACH, K.I. BIRKELAND, H.R. NORLI, S.H. RINGERTZ:
Urine Storage Conditions and Steroid Profile Analysis
99 download 

H. GEYER, U. MARECK-ENGELKE, W. SCHÄNZER, M. DONIKE:
The Cologne Protocol to Follow up High Testosterone / Epitestosterone Ratios
107 download 

C. AYOTTE, A. CHARLEBOIS, S. LAPOINTE, D. BARRIAULT, M. SYLVESTRE:
Validity of Urine Samples: Microbial Degradation
127 download 

U. MARECK-ENGELKE, U. FLENKER, W. SCHÄNZER:
Stability of Steroid Profiles (6): The Influence of Oral Contraceptives on Steroid Profiles
139 download 

C. SCHWEIZER, C. CARDIS, M. CAUDERAY, L. RIVIER, M. SAUGY:
T/E Ratio Variations through Puberty in Male Adolescents
159 download 

S.B. COUTTS, A.T. KICMAN, D.A. COWAN:
Intramuscular Administration of 5a-Dihydrotestosterone Heptanoate: Changes in the Urinary Hormone Profile
173 download 

W. SCHÄNZER:
Metabolism of Anabolic Androgenic Steroids: 5a- and 5b-Reduction of 3-Keto-4-ene Steroids
185 download 

U. FLENKER, E. NOLTEERNSTING, W. SCHÄNZER, M. DONIKE:
Detection and Classification of Different Male Steroid Profiles by Means of Multivariate Statistics
203 download 

IV Sample Preparation

PH. DELAHAUT:
Immunoassays and Immunoaffinity Chromatography for the Detection of Drug Residues
211 download 

M. MACHNIK, P. DELAHAUT, S. HORNING, W. SCHÄNZER:
Purification and Concentration of Anabolic Steroids by Immuno Affinity Chromatography (IAC)
223 download 

A. GOTZMANN, H. GEYER, W. SCHÄNZER:
HPLC Clean-up for Urine Samples with Disturbing Background for Confirmation of 17ß-methyl-5ß-androst-1-ene-3a,17a-diol (Epimetenediol)
239 download 

G. OPFERMANN, W. SCHÄNZER:
Trimethylsilylation - Aspects for Derivatisation
247 download 

V Techniques of MS Detection

S. HORNING, W. SCHÄNZER:
Basics of High Resolution Mass Sectrometry
253 download 

S. HORNING, W. SCHÄNZER:
Steroid Screening Using GC/HRMS
261 download 

M. GARLE:
Ion Trap - Different Problems and Discussion
271 download 

S. HORNING, H. GEYER, M. MACHNIK, W. SCHÄNZER, A. HILKERT, J. OEßELMANN:
Detection of Exogenous Testosterone by 13C/12C Analysis
275 download 

VI Peptide Hormones

P. LAIDLER, D.A. COWAN, R.C. HIDER, A.T. KICMAN:
Qualitative Analysis of hCG for Confirmatory Purposes
285 download 

C. CARDIS, C. SCHWEIZER, M. SAUGY, L. RIVIER:
Ketoconazole Test: Blood versus Urine Values
305 download 

A. BREIDBACH, P. PLATEN, W. SCHÄNZER:
Erythropoietin - Influence of Physical Strain and Application on Concentrations in Blood and Urine
319 download 

VII Improvement of Detection

A. DURUSSEL, C. CARDIS, C. SCHWEIZER, L. RIVIER, G. BRISSON, M. SAUGY:
Influence of Creatine Intake upon Biochemical Parameters in Urine
323 download 

E. UMPIERREZ, D. LORENZO:
Three Cases of Misleading Results in Drug Analysis re-analyzed by GC/MS
335 download 

R. VENTURA, G. GONZÁLEZ, M.T. SMEYERS, R. DE LA TORE, J. SEGURA:
Screening of ß-Adrenergic Antagonists in Human Urine by ELISA Techniques
343 download 

D. DE BOER, M. VAN BEEK, C.H.J. BEKKERS, R.A.A. MAES:
The Detection of the Administration of Salmeterol in Urine after Inhalation
357 download 

S. ZHU, S. YANG:
Determination of Benzthiazide in Human Urine by HPLC-ES/MS *)
371 download 

S. YANG, S. ZHU, Z. YANG:
Detection of Mesocarb in Human Urine by HPLC-Electrospray / Mass Spectrometry *)
377  download 

VIII Organisation of Doping Control

F.T. DELBEKE:
Doping Control in Flanders: Facts, Results and Statistics
385 download 

E. NOLTEERNSTING, I. MATONDO, E. MURWISI, W. SCHÄNZER:
Brief Report of the Doping Analyses during the 6th All Africa Games in Harare 1995 (September, 13th - 24th)
403 download 
 
*) These papers were presented during the 13th Cologne Workshop on Dope Analysis 12th to 17th March, 1995. As a matter of fact they were not published in the Proceedings connected to this Workshop: 'Recent Advances in Doping Analysis (3), Köln 1996'. We apologize for this misunderstanding.

The Editors 

______________________________________________________________________

Proceedings of the 13th Cologne Workshop on Dope Analysis, 12.-17. March 1995
In: M. Donike, H. Geyer, A. Gotzmann, U. Mareck-Engelke (eds.) Recent Advances 
In Doping Analysis (3). Sport und Buch Strauß - Köln 1996  

Table of Contents

Ad personam Prof. Dr. Manfred Donike

W. Schänzer
J. Segura

I Metabolism of Anabolic Steroids

S. Rendic:
Human Cytochrome P450 (CYP) Enzymes in Doping Control: Metabolism, Interactions, Adverse Effects
13 download

D. Goudreault and C. Ayotte:
Investigation of Mesterolone Urinary Metabolites by GC/MS
55 download 

L. D. Bowers:
Metabolic Pattern of Milbolerone
81 download 

V.P. Uralets, P.A. Gillette, B. DuVall and R.K. Latven:
Trenbolone: Screening and Confirmation
83 download 

II Steroid Profiling

H. Geyer, W. Schänzer, U. Mareck-Engelke and M. Donike:
Factors Influencing the Steroid Profile
95 download 

M. Ueki, A. Ikekita, M. Fujisaki, T. Hiruma and M. Okano:
Steroid Profiles, Disease and Gender Verification - Inborn Errors of Metabolism -
115 download 

K. Chrostowski, M. Daniewski, E.Partyka, I. Plewka and W. Szpindler:
Effect of Metandienone Abuse on the Urinary Steroid Profile in Body Builders
131 download 

U. Mareck-Engelke, H. Geyer, U. Schindler, U. Flenker, R. Iffland and M. Donike:
Influence of Ethanol on Steroid Profile Parameters
143 download 

T.J.A. Seppenwoolde-Waasdorp, D. de Boer, H.M.J. Van Engelen, A.D. Vrijdag and R.A.A. Maes:
Evaluation of Endogenous Steroid Profiles in Urine (2) - Effects of Ethanol Intake Reinvestigated
157 download 

A. Leinonen, T. Karila and T. Seppälä:
An Increased Testosterone to Epitestosterone Ratio due to High
Doses of Ethanol - A Case Report on a Female Powerlifter
167 download 

U. Mareck-Engelke, U. Flenker and M. Donike:
Stability of Steroid Profiles (5): The Annual Rhythm of Urinary Ratios and Excretion Rates of Endogenous Steroids in Female and its Menstrual Dependency
177 download 

E. Nolteernsting, W. Schänzer and M. Donike:
Experiences with D3Testosterone/D3 Epitestosterone as Internal Standards for Screening and Confirmation of T/E Ratios
191 download 

III Dihydrotestosterone (DHT) and Endogenous Steroids

W. Schänzer, S. Horning and M. Donike:
Synthesis and Metabolism of [16,16,16-2H3]-5a-Dihydrotestosterone
201 download 

H. Geyer, W. Schänzer, U. Schindler and M. Donike:
Changes of the Urinary Steroidprofile after Sublingual Application of Dihydrotestosterone (DHT)
215 download 

M. Ueki, M. Fujisaki, A. Ikekita, T. Hiruma and M. Okano:
Some Followed up Cases of Doping with Naturally Occurring Steroids - Testosterone and Dihydrotestosterone
231 download 

IV Improvement of Analytical Methods

R. De la Torre, R. Badia, J. Segura, M. Pavesi, A. Artola, A. Redón and R. Herrera:
Quantitation of Drugs of Abuse by GC-MS. The European Experience
247 download 

D. de Boer, K.M. Höld, B. van der Horst-Brigot, M. Elhamdi, L. van Schaik, J. Zuidema and R.A.A. Maes:
Potential Role for Saliva as a Biological Specimen in Doping Analysis
259 download 

Sanaullah and L.D. Bowers:
Direct Measurement of Testosterone and Epitestosterone Glucuronates and Sulfates with HPLC/MS and HPLC/MS/MS
271 download 

L.D. Bowers:
Steroid Analysis on the Ion Trap: Selective Ion Storage; Resonant and Nonresonant MS/MS
277 download  

D. Thieme, J. Grosse, R. Lang and R.K. Mueller:
Application of High-Resolution-MS and Tandem-MS to the Identification of Anabolic Agents
285 download 

L. Huber:
Good Laboratory Practice in Doping Control
299 download 

M. Kabouris, P. Platen and M. Donike:
Detection of Human Growth Hormone in Urine of Athletes
313 download 

V Advances in Detection

S. Horning, W. Schänzer and M. Donike:
Steroid Profiling in Human Blood
325 download 

M. Saugy, C. Cardis, C. Schweizer, N. Dimo-Simonin, F. Grange, C. Brandt-Casadevall and L. Rivier:
Identification Problems of Urine Samples in Doping Controls Resolved by DNA-PCR
337 download 

I. Seinsch, G. Sigmund, S. Horning and M. Donike:
Detection of Salbutamol in Horse Urine
349 download 

R.K. Mueller, J. Grosse, R. Lang and D. Thieme:
Identification and Evaluation of Unusual Screening Results in Doping Control
357 download 

M. Garle, C. Beckman, K. Stenback and U. Bergman:
Prevention of Misuse of Anabolic Steroids in Sweden
365 download 

E. Nolteernsting, G. Opfermann and M. Donike:
1-(N,N-Diisopropylamino)-n-Alkanes: A New Reference System for Systematical Identification of Nitrogen Containing Substances by Gas-Chromatography and Nitrogen Specific or Mass Spectrometrical Detection
369 download  

__________________________________________________________________

Proceedings of the 12th Cologne Workshop on Dope Analysis, 10.-15. April 1994
In: M. Donike, H. Geyer, A. Gotzmann, U. Mareck-Engelke (eds.) Recent Advances 
In Doping Analysis (2). Sport und Buch Strauß - Köln 1995 

Table of Contents

I   Blood Analysis - Expectations - Possibilities

K. I. Birkeland, P. Hemmersbach, E. Haug:
Blood Sampling in Doping Control - Which New Information may be Obtained?
9 download

S. Rendic:
Binding of Anabolic Steroids to Human Serum Albumin and Possible  Interactions with other Drugs
15 download 

S. Horning, W. Schänzer, M. Donike:
Steroid Profiling in Human and Horse Blood: Some Results
39 download 

S. Horning, W. Schänzer, M. Donike:
GC/HR MS Determination of the Serum/Plasma
Testosterone / 17-a-Hydroxyprogesterone Ratio and its Significance
51 download 

X. De la Torre, J. Segura, A. Polettini:
Detection of Testosterone Esters in Human Plasma by GC/MS and GC/MS/MS
59 download 

C. Ayotte:
Determination of Free Methyltestosterone in Plasma Samples
81 download 

II  Steroid Analysis

W. Schänzer, M. Donike:
Synthesis of Deuterated Steroids for GC/MS Quantification of Endogenous Steroids
93 download 

E. Nolteernsting, H. Geyer, U. Mareck-Engelke, W. Schänzer, M. Donike:#
Standardisation of the T/E-Determination by Deuterated Internal Standards
113 download 

U. Mareck-Engelke, H. Geyer, M. Donike:
Stability of Steroid Profiles (3): Ratios and Excretion Rates of Endogenous Steroids in Male Urines Collected over 24 Hours
121 download 
 
U. Mareck-Engelke, H. Geyer, M. Donike:
Stability of steroidprofiles (4): the circadian rhythm of urinary ratios and excretion rates of endogenous steroids in female and its menstrual dependency.
135 download 

M. Donike, U. Mareck-Engelke, S. Rauth:
Statistical Evaluation of Longitudinal Studies, Part 2: The Usefulness of Subject Based Reference Ranges in Steroid Profiling
157 download 

T.J.A. Seppenwoolde-Waasdorp, R.P.G. van Heeswijk, D. de Boer, R.A.A. Maes:
Evaluation of Endogenous Steroid Profiles in Urine (1)
Effect of Illness and the Use of Antibiotics
167 download 

G. Debruyckere, R. de Sagher, C. Van Peteghem:
Detection of Interferences in Urinary Anabolic Steroid Analysis
173 download 

P. Hemmersbach, S. Tomten, S. Nilsson, H. Oftebro, O. Havrevoll, B. Oen, K. Birkeland:
Illegal Use of Anabolic Agents in Animal Fattening - Consequences for Doping Analysis
185 download 

L. D. Bowers:
Effect of Sulfinpyrazone on Urinary Secretion of Steroid Conjugates
193 download 

H. Geyer, U. Mareck-Engelke, E. Nolteernsting, G. Opfermann, M. Donike:
The Matrix Problem in Calibration of the GC/MS for Endogenous Steroids. The Search for an Artificial Urine
199 download 

W. Schänzer, H. Geyer, A. Gotzmann, S. Horning, U. Mareck-Engelke, R. Nitschke, E. Nolteernsting, M. Donike:
Endogenous Production and Excretion of Boldenone (17ß-hydroxyandrosta-1,4-dien-3-one), an Androgenic Anabolic Steroid
211 download 

III  Detection of Peptide Hormones

M. Saugy, C. Cardis, L. Rivier:
Urinary Human Growth Hormone (U-HGH): I Measurements in Non-Athlete Volunteers after Intra-Muscular or Subcutaneous hGH Injections
213 download 

M. Saugy, C. Cardis, L. Rivier, G. Brisson, C. Ayotte, P. Hemmersbach, E. Haug, J. Segura:
Urinary Human Growth Hormone (U-HGH): II Measurements in Competition Tests: More the Expression of the Renal Function than the Endocrinological Status
223 download 

C. Liu, L.D. Bowers:
Studies toward Confirmation of HCG using HPLC/MS
235 download 

IV  Improvement of Analytical Techniques

K.O. Börnsen, E. Gassmann, M. Schär, H.M. Widmer:
Matrix Assisted Laser Desorption and Io nization - Mass Spectrometry: A New Analytical Tool
243 download 

M. Herold, H. Dollekamp, R. Grimm:
Micropreparative Peptide Separation by Capillary Electrophoresis 
251 download 

L. Bowers, V. Abbott:
Evaluation of Extraction Methods and Third Generation HPLC columns for Analysis of Diuretics
261 download 

A. Gotzmann, W. Schänzer, H. Geyer, M. Donike:
Detection of Trenbolone by HPLC 
269 download 

D. Thieme, J. Große, R. Lang, R.K. Mueller:
Detection of Mesocarb Metabolite by LC - TS/MS 
275 download 

F.T. Delbeke:
A Threshold Level for Theophylline in Urine: Preliminary Results 
285 download 

A. Breidbach, G. Sigmund, M. Donike:
Combination of Screening Procedures - Mesocarb Detectionas an Example
301 download 

D. de Boer, R.D. van Ooijen, R.A.A. Maes:
Thermostable Derivatives of Mesocarb and its p-hydroxy Metabolite
305 download 

J. Große, R. Lang, R.K. Mueller, D. Thieme:
Detection of Tamoxifen Metabolites in Urine by GC/MS
317 download 

D. de Boer, R.M.A. van de Wal, K.L. Bos, R.A.A. Maes:
Fluoroacyl-(S)-prolyl Derivatization for the Enantiomeric Profiling of 3,4-methylenedioxymetamphetamine, Methylphenidate, Ephedrines and their Major Metabolites  in Urine
329 download 

L. Rivier, M. Saugy:
Coca and Cocaine: What can be done in Doping Analysis
339 download 

A. Tsoutsoulova-Draganova:
Investigation on Products of Thiazide Diuretics in Human Urine 
357 download 

A. Lisi, R. Kazlauskas, G. Trout, E. Nolteernsting, M. Donike:
Buprenorphine by GC-MS after Derivatization by Direct Extractive Alkylation
367 download 

C. Ayotte, A. Charlebois, D. Goudreault, C. Lévesque:
Improvements of Drug Detection and Analysis by Appropriate Preparation of the Injection Port of the Gas Chromatograph 
375 download 

V  Organisation of Doping Analysis and Doping Control

P. Hemmersbach, B. Bjerke, K. Birkeland, E. Haug:
Short Report from the Doping Analysis During the XVII Olympic Winter Games
393 download 

J. Segura, R. de la Torre, J.A. Pascual, R. Ventura, M. Farré, R.R. Ewin, J. Cami:
Antidoping Control Laboratory at the Games of the XXV Olympiad Barcelona'92.
Part I. Management of Resources
403 download 

J. Segura, R. de la Torre, J.A. Pascual, R. Ventura, M. Farré, R.R. Ewin, J. Cami:
Antidoping Control Laboratory at the Games of the XXV Olympiad Barcelona'92.
Part II. Strategies and Results  
413 download 

I.Bruunshuus, D. Cowan, G. Hill, H. Olesen:
Quantities and Units in Drugs of Abuse
431 download  

____________________________________________

Proceedings of the 11th Cologne Workshop on Dope Analysis, 1993
In: M. Donike, H. Geyer, A. Gotzmann, U. Mareck-Engelke (eds.) Recent Advances 
In Doping Analysis (1). Sport und Buch Strauß - Köln 1994 

Table of Contents

I. Steroid Analysis

W. Schänzer and M. Donike:
Review - Synthesis of 6ß-Hydroxy-3-Keto-4-Ene Steroids. And Synthesis of 6ß-Hydroxy Metabolites of Anabolic Steroids
9 download

A. Leinonen, L. Savonen and K. Kuoppasalmi:
Improved Purification of Anabolic Steroids for GC/MS-Analysis
25 download 

M. Donike, S. Rauth, U. Mareck-Engelke, H. Geyer and R. Nitschke:
Evaluation of Longitudinal Studies, the Determination of Subject Based Reference Ranges of the Testosterone/Epitestosterone Ratio
33 download

J. Baenziger and L. Bowers:
Variability of T/E Ratios in Athletes
41 download 

T.J.A. Waasdorp, D. de Boer, L. van Schaik, H. Gerretsen, P. Schoone and J.H.H. Thijssen:
Testosterone and Epitestosterone under certain Physiological and Pathological Conditions
53 download 

P. Hemmersbach, K. Esbensen, H.R. Norli, K.I. Birkeland and F. Westad:
Chemometric Evaluation of Urinary Steroid Profiles in Doping Control
61 download

X. De la Torre, J. Ortuno, J. Cabrer and E. Vilardell:
Stanozolol, Metenolone and Steroid Profile
69 download 

U. Mareck-Engelke, H. Geyer and M. Donike:
Stability of Steroid Profiles (2): Excretion Rates from Morning Urines
85 download 

D. de Boer, L. van Schaik, T.J.A. Waasdorp and R.A.A. Maes:
The Influence of Propyphenazone on the Excretion of Steroids
91 download 

H. Geyer, U. Mareck-Engelke, W. Schänzer and M. Donike:
Simple Purification of Urine Samples for Improved Detection of Anabolic and Endogenous Steroids
97 download 

D. de Boer, T.J.A. Waasdorp, P. Schoone and J.H.H. Thijssen:
The Power of the Ketoconazole Test
105 download 

II. Improvement of Analytical Techniques

C. Ayotte:
Old Doping Agent, Old Method: Pemoline TMS-Derivative
111 download 

PJ van der Merwe:
Simultaneous Quantification of Ephedrines in Urine by HPLC
117 download 

A. Aumatell and R.J. Wells:
Chiral Differentiation of the Optical Racemethorphan and Raceorphanin Urine by Capillary Zone Electrophoresis
125 download